Sm04554

[lacazette]

Well they used it once daily in the trials, so let's hope their level activation is strong enough. Maybe severe hair loss sufferers will be able to use it twice daily ^^

In mouse just one topical Wnt activation induced anagen phase of the HFs, whereas 6 applications not only induce anagen phase, but also lead to ectopic HF formation from existing ones.


another study mentioning Wnt, 2014

The Wnt/β-catenin pathway plays an important role in the initiation, development, and growth of hair follicles.
The transient activation of β-catenin results in hair regrowth in mice, while ablation of β-catenin results in dramatic hair shortening and abnormal regeneration of hair in the dermal papilla of mouse hair follicles [19, 33]. The levels of β-catenin in the dermal papilla are high in the anagen phase but low in the catagen and the telogen phases [18, 34]. Furthermore, the interaction between β-catenin, androgen receptors, and keratinocyte growth inhibition through modification of Wnt signaling contributes to androgenic alopecia, a common form of hair loss

[seanway]

But if we use something topically with low half life it should be a matter of concern isnt ? I hope SM04554 will have nice result.

[lacazette]

It's been 4 years, so I think she didn't found for the moment a topically safely way to inhibit this gene with a molecule

Whereas samumed have the safely molecule to activate the wnt pathway

So yes I think SM04554 will make our Wnt signaling pathway come back to his normal activity. The gene inhibit the pathway but we will upregulate this pathway daily. So I really think that SM will stop (or slow for years) the hair loss, and even more activation will give regrowth. But abberant activation give skin cancer, so they have to be careful.
But our Wnt signaling pathway is inhibited right now, so we just need an upregulation that lead to his normal activity, so it's far from cancer aberrant activity i think

[seanway]

So how to fight APCDD1 ? sm04554 ?

[lacazette]

Look at this:

Angela Christiano, Ph.D.

Hair-Loss Treatment with Hair-Loss Gene Promotes New Hair Growth, Regulates Male-Pattern Baldness

The discovery of the APCDD1 gene, which causes hair loss, has potential for future male-pattern baldness treatments, and for regulating male and female hair growth, density of hair, and hair graying.

the APCDD1 gene inhibits the Wnt signaling pathway

Laboratory researchers have targeted this Wnt pathway to turn on or off hair growth in mice, but until now, the pathway did not appear to be involved in human hair loss. Their findings provide evidence that hair-growth patterns in humans and in mice are similar, and they suggest for the first time that manipulating the Wnt pathway may have an effect on human hair-follicle growth.

Unlike commonly available hair loss treatments that involve blocking hormonal pathways, treatments involving modulation of the APCDD1 gene and the Wnt pathway would be non-hormonal, which may enable many more people suffering from hair loss to receive such therapies

Advantages:
•Surgical treatment options for hair loss require multiple costly procedures. This technology represents a way to modulate hair growth without the need of surgery as APCDD1 represents a potential drug target.
•Targeting APCDD1 will not only prevent further hair loss but has the potential to grow new hair, in contrast to current medical alternatives.
"

http://innovation.columbia.edu/technologies/2419_hair-loss-treatment-with-hair-loss-gene-promotes-new-hair-growth-regulates-male-pattern-baldness-and-graying-hair

So it's seems there's two ways: inhibit APCDD1
or upregulate the pathway that is inhibited by this gene ( samumed )

Samumed patented their Wnt pathway activators in 2011 http://www.google.com.na/patents/EP2605652A1?cl=un