Sm04554

[unbalding]

In preclinical in vivo studies, SM04554 has been shown to regenerate new hair follicles and increase hair count in multiple animal models

Regenerate new hair follicles!! Sounds enticing, lets hope thats not just on rats and mice though.

Sounds good, but how can you REgenerate new hair follicles. You can generate new heir follicles, or you can regenerate old hair follicles. I think they mean the latter.

I'm a little disappointed because I was hoping they would announce phase II results, but the PR says phase I only. They seem very positive about their results though, so that's encouraging.

[champpy]

In preclinical in vivo studies, SM04554 has been shown to regenerate new hair follicles and increase hair count in multiple animal models

Regenerate new hair follicles!! Sounds enticing, lets hope thats not just on rats and mice though.

[MasterRay]

hair congress

http://www.prnewswire.com/news-releases/samumed-llc-to-announce-clinical-data-on-potential-treatment-of-androgenetic-alopecia-at-the-world-congress-for-hair-research-300181064.html

[Sogeking]

We won't know much from Phase 1 results. They were only for 14 days.
And we have no idea if NW5s were amongst those that reported hair growth.

[Superuser]

Seems like they already published their phase 1 results:

https://www.samumed.com/files/WCHR2015.2015-G-41-NAHRS.abstract.submission.20150403.pdf

[jpar]

lacazette do you know Swisstemples ? he has his own site and is friends with hellouser, the pgd2 protocol worked out great for him! he's growing hair in the front too! someone said he got banned from forums is this true???

[champpy]

I really hope this company succeeds. they seem to be making ground in several areas

[SriHanuman]

https://www.samumed.com/files/american-college-of-rheumatology-acr-annual-meeting-11-03-2015.pdf

And if SM works, they will surely have a similar presentation...

[rambo007]

lacazette you are great. thanks for giving us so much information.

[baldybald]

If someone can confirm me but I think I saw before that Sarah Millar was involved and supervising one of the locations of the phase2 trial, no?

Follica's team talked years ago about how Wnt activation increase the wounding HF neogenesis, and that safe way were needed, so surely they are interested

If you add the luis Garza discovery (who collaborated a lot with Cotsarelis) about TLR3 activation that is the first signaling pathway involved that could induce the formation of hair follicle on a wound (and that there were already companies developing safe chemical TLR3 activation ) , Follica could have good tools to test soon

follica was testing years ago on humans their wounding approach with some lithium things, etc

Now imagine, make the wound, then TLR3 activation to make the cells recreate the HF,IFE and SG and then Wnt activation to make this hair follicle become bigger with robust growth (with also growth factors, FGF9, etc)

I wonder what kind of results this will give, maybe enough or maybe still not, but nothing to compared with their lithium and FGF approaches, it's another level, far more powerful
and the safe chemicals applications of Wnt and TLR3 activations are now becoming possible so let's hope Follica is planning new protocols testing soon (with wnt, tlr3, and of course other things based on Cots and millar recent knowledge)
(and maybe the recent Lgr6+ stem cells protocol from the plastic surgeons for creation of a hair follicle in a wound will have an impact)
a combo : -wounding+TLR3+Lgr6 scaffolded cells transplant+WNT+FGFs- would look like a damn promising protocol

This is so advanced from the king of hair loss reach Dr Cots. Thank you lacazette for these important news and keep us all updated

[lacazette]

If someone can confirm me but I think I saw before that Sarah Millar was involved and supervising one of the locations of the phase2 trial, no?

Follica's team talked years ago about how Wnt activation increase the wounding HF neogenesis, and that safe way were needed, so surely they are interested

If you add the luis Garza discovery (who collaborated a lot with Cotsarelis) about TLR3 activation that is the first signaling pathway involved that could induce the formation of hair follicle on a wound (and that there were already companies developing safe chemical TLR3 activation ) , Follica could have good tools to test soon

follica was testing years ago on humans their wounding approach with some lithium things, etc

Now imagine, make the wound, then TLR3 activation to make the cells recreate the HF,IFE and SG and then Wnt activation to make this hair follicle become bigger with robust growth (with also growth factors, FGF9, etc)

I wonder what kind of results this will give, maybe enough or maybe still not, but nothing to compared with their lithium and FGF approaches, it's another level, far more powerful
and the safe chemicals applications of Wnt and TLR3 activations are now becoming possible so let's hope Follica is planning new protocols testing soon (with wnt, tlr3, and of course other things based on Cots and millar recent knowledge)
(and maybe the recent Lgr6+ stem cells protocol from the plastic surgeons for creation of a hair follicle in a wound will have an impact)
a combo : -wounding+TLR3+Lgr6 scaffolded cells transplant+WNT+FGFs- would look like a damn promising protocol

[unbalding]

I think a few pages back someone said at the congress they are discussing phase 1 only. But they might let something slip about phase 2

It looks like that's the plan, but I'm still hoping.

[champpy]

I think a few pages back someone said at the congress they are discussing phase 1 only. But they might let something slip about phase 2

[nameless]

I believe their initial phase II is complete but they started a 2nd phase II a few months later, so they may very well release the initial results here.

You might be right. They may release some results from their original phase 2 study at the coming hair loss congress. That study is complete and during their phase 1 study they collected results during the study so they may have done the same thing in their original phase 2 study and if they did then they probably have some information about their original phase 2 study.

I wish we could get someone to go to the congress and interview Samumed.

Also, since they collected evidence during the phase 1 study that means they likely collected evidence during the original phase 2 and since they are still pursuing their drug deeper into trials that means that the evidence they have so far collected during the original phase 2 study is probably good news.

[rdawg]

I thought phase 2 completed in October? They are still doing a IIb, but that is separate.

I believe their initial phase II is complete but they started a 2nd phase II a few months later, so they may very well release the initial results here.