Sm04554

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  • JayM
    replied
    Originally posted by ghostrider
    Hi mates

    What's so special about this? It works with wnt?

    Valproic acid (VPA), a widely used anticonvulsant, inhibits glycogen synthase kinase 3β and activates the Wnt/β-catenin pathway, which is associated with hair growth cycle and anagen induction. To assess the efficacy of topical VPA for treating androgenetic alopecia (AGA), we performed a randomized, …


    I read valproic acid has been around for years & its very cheap.

    Can anyone comment on this ?
    Swiss uses VPA for WNT activation.

    Leave a comment:


  • ghostrider
    replied
    Hi mates

    What's so special about this? It works with wnt?

    Valproic acid (VPA), a widely used anticonvulsant, inhibits glycogen synthase kinase 3β and activates the Wnt/β-catenin pathway, which is associated with hair growth cycle and anagen induction. To assess the efficacy of topical VPA for treating androgenetic alopecia (AGA), we performed a randomized, …


    I read valproic acid has been around for years & its very cheap.

    Can anyone comment on this ?

    Leave a comment:


  • JayM
    replied
    safety and efficacy

    Leave a comment:


  • Dobler
    replied
    Originally posted by Swooping
    At the hair congress they will be presenting the results from the 1st phase of the clinical trial..
    1st phase of clinical isn't aimed on safety? It won't tell us much about efficiency right?

    Leave a comment:


  • nameless
    replied
    Originally posted by Sogeking
    Good find. Although Phase 1 is primarily intended for determining safety we might get a glimpse at effectiveness.
    They might give some hints as to how things are going in their original phase 2 study that is just completing NOW.

    Leave a comment:


  • Tenma
    replied
    Originally posted by Swooping
    At the hair congress they will be presenting the results from the 1st phase of the clinical trial..
    Good! I wasnt expecting a presentation from Samumed.

    Lets hope Hellouser can record this one

    Leave a comment:


  • ShookOnes
    replied
    Would gains be permanent with this anyone guess?

    Leave a comment:


  • Sogeking
    replied
    Originally posted by Swooping
    At the hair congress they will be presenting the results from the 1st phase of the clinical trial..
    Good find. Although Phase 1 is primarily intended for determining safety we might get a glimpse at effectiveness.

    Leave a comment:


  • Swooping
    replied
    At the hair congress they will be presenting the results from the 1st phase of the clinical trial..

    Safety and Efficacy of a Topical Treatment (SM04554) for Androgenetic Alopecia (AGA): Results from a Phase 1 Trial Yusuf Yazici, MD | USA

    Leave a comment:


  • Swooping
    replied
    So how many trials are these guys running now? Did they already finish a clinical trial? Perhaps they will present some preliminary data on the congress on a poster whatsoever.

    Leave a comment:


  • JayM
    replied
    Originally posted by champpy
    Does anyone know if their drug is a topical or oral med?

    I cant imagine them being such a big sponser of the congress and not presenting anything. Dude, if they even showed a product logo id flip my shyt
    wow

    Leave a comment:


  • noisette
    replied
    Originally posted by champpy
    Does anyone know if their drug is a topical or oral med?

    Leave a comment:


  • champpy
    replied
    Does anyone know if their drug is a topical or oral med?

    I cant imagine them being such a big sponser of the congress and not presenting anything. Dude, if they even showed a product logo id flip my shyt

    Leave a comment:


  • Tomtom21
    replied
    I feel like samumed may wait to release results from the clinical trial ending this month unitl they have the results from the new smaller trial ending in February.. But the anticipation is slowly starting to kill me lol hopefully they release something regarding the chemical or its effectiveness come the hair congress

    Leave a comment:


  • lacazette
    replied
    Good! I still strongly believe in them, when you know Wnt/b catenin act as the key cascade with others, it gives high hopes


    Does someone understand the patent's world? and could explain me what does the recent patents applications publications on this 22 october , and that are concerning us, mean



    B- and y -diketones and y -hydroxyketones as wnt/ b -catenin signaling pathway activators




    -First why on 22 oct they are two applications of the same patent? what does that mean?

    -And it's the 'same' patent that we already posted here in 2014, so what are these new ones for, or what are the différences? (though it's just 'look like' the same patent, so maybe there's could be new things in it as i don't had the time to read it)

    Leave a comment:

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