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So this article is clearly speaking on the negatives of the 21st century cures act, but the only real thing i got from it was the bill removes phase 3 as a requirement from the approval process! If it passes and sm04554 is successful we very well may see it on shelves by late 2016.
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Modulating hair follicle size with Wnt10b-DKK1 pair during hair regeneration
"Here, we show that in response to prolonged ectopic Wnt10b-mediated β-catenin activation, regenerating anagen hair follicles grow larger in size. In particular, the hair bulb, dermal papilla and hair shaft become enlarged"
"these data suggest that WNT10b may have a proliferative effect on hair matrix and DP cells and that interactive signaling between extra epithelial and mesenchymal cells may later lead to the enlarged hair follicle phenotype. Furthermore, since the hair fiber and IRS are derived from hair keratinocyte precursors (34), differentiation of the increased matrix cell progenitor pool or their progeny may lead to a thickened hair shaft."
"In the present study, we found aberrant localization of hyperproliferative hair stem cells during WNT10b induction. Therefore, WNT10b might stimulate hair stem cells to proliferate and migrate from the bulge region to replenish hair matrix cells."
"Notably, in our study, DP size correlated with hair follicle size. It was reported that epidermal activation of β-catenin results in ectopic hair formation associated with increased fibroblast proliferation"
"Therefore, it is possible that the WNT10b-induced canonical Wnt/β-catenin pathway could also directly promote proliferation and enlargement of the DP"
This is how SM04554 should work for us. Damn , that would mean even our miniaturized hair could grow better and come back to normal terminal hair (like we saw in few cases of minox/fin, but with that modulation of Wnt pathway, they directly doing what follicles don't do well for hair formation because of the DHT and other factors.
Instead of androgen drug that just reduce a factor that lead to this affected formation process.
The more I read on wnt/b catenin, the more im convince it is the more promising thing. Even big Norwood could have an ht, cause SM will work on all follicles, so then ameliore the ones of us with poor donor area zone, and we know how it is the most important aspect for a good HTComment
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Lacazette you find some really good stuff. Quick question as I'm not so pro with all this, where are you finding all these articles? Is it the same people doing the research?Comment
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Hey jay no no it is published studies from researchers all other the world
To find them I type key words in Google, like for an exemple "Wnt/β-catenin Signaling Pathway, hair follicle", and you choose "results from the last year". Like that, when you write 'scientific' key words, the majority of the links will lead to published studies from researchersComment
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Aha must just be my inability to do things efficiently then. It sounds like a lot of different researchers are all going down this route. I guess it's because manipulating the wnt pathway has been proven to work on humans in other areas so it's a link from bloody rats to humans haha.Comment
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We need to get this SM stuff.
I think it's pretty odd that the guy who said the nurse told him it doesn't work hasn't come back. I think that, that is a sign that SM is working and he's falling into line with the company's nondisclosure rules because he does not want to risk being cut off.Comment
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LOL! You're right.
I meant to say that it "could be" a sign that SM is working and he's falling into line with the company's nondisclosure rules because he does not want to risk being cut off."
I don't know why I typed it IS a sign of that when I meant to say it MIGHT BE a sign of that.
But I do have a point that it MIGHT BE a sign of what I indicated. The poster was obvious willing to blast out info for awhile and then all of a sudden he clammed up. I do think that, that is most likely a good sign. If SM didn't work he most likely would be willing to keep violating the nondisclosure agreement because he wouldn't care much if they dumped him.Comment
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Like I later said, I meant to say that he MAY HAVE gone quiet because the treatment is working and he doesn't want to risk being dumped. I know I said that it IS a sign that the treatment is working and he doesn't want to be dumped, but that is not what I meant to say. Still, I do believe that the fact that he has clammed up is a good sign. I think it means that he doesn't want to be cut loose.Comment
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None of the things you stated would prevent him from continuing to post and none of them are likely to have happened in such a short period of time. Also, it doesn't matter how long he was on the trial because he could have learnt that the drug was working from other ways besides the drug actually working on him. For example, the same nurse who told him that she didn't see any improvement on any patients may have started seeing some improvement on patients and she may have told him or he may have talked to test-patients who were having success with the drug.
The point is that he's stopped sharing info for some reason and in my view that seems like it's probably a good sign. I'm not saying that I'm sure it's a good sign; I'm just saying that it seems like it's PROBABLY a good sign. It shows that for some reason he's decided to become compliant.Comment
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Yes I agree, it could be a good sign more than a bad. fingers crossed! I really believe in this all Wnt pathway world, we will know more at the hair congressComment
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