Sm04554

[rdawg]

I would suspect they could not find enough participants at their existing sites and/or would rather open a new site than wait for new recruits.

These guys must have some deep pockets either way.

They definitely started the trial, just probably wanted to add more people that would finish at a later date.

I was invited to join the trial back in Feb, but obviously wasn't eligible due to FIN, which I imagine would eliminate alot of people who would have knowledge of it.

[It's2014ComeOnAlready]

I find it really hard to believe that they would be recruiting for a phase they're already in. What if you can't find participants in time, get them through months of treatment, enough so that all data can be measured in the end? It's quite risky to be recruiting while time is ticking, and millions of dollars are at stake. It would make a lot more sense to have all of your participants enrolled before the trial, so there aren't any issues like this.

[rdawg]

I find it really hard to believe that they would be recruiting for a phase they're already in. What if you can't find participants in time, get them through months of treatment, enough so that all data can be measured in the end? It's quite risky to be recruiting while time is ticking, and millions of dollars are at stake. It would make a lot more sense to have all of your participants enrolled before the trial, so there aren't any issues like this.

It's not that crazy

They may have started the trial completely in January, but with say 200-250 participants, and just added in the remaining the in the next two months, who will get slightly less time.

If I'm a company starting a trial, I'm not going to wait the extra 1-2 months for the remaining 50 or so participants to come in, I'll just go forward with the 200 or so and use the rest as extra data.

The same thing was happening with the CB trial as well, people claimed that had begun participating in that trial while it was still recruiting(i was invited to that one as well, it was the same clinic in minnesota as this one).

[It's2014ComeOnAlready]

It's not that crazy

They may have started the trial completely in January, but with say 200-250 participants, and just added in the remaining the in the next two months, who will get slightly less time.

If I'm a company starting a trial, I'm not going to wait the extra 1-2 months for the remaining 50 or so participants to come in, I'll just go forward with the 200 or so and use the rest as extra data.

The same thing was happening with the CB trial as well, people claimed that had begun participating in that trial while it was still recruiting(i was invited to that one as well, it was the same clinic in minnesota as this one).

Well, they're still recruiting with 5 months to go...cutting it kind close, no? I might email a site to find out if they're still recruiting for phase 2.

[Seuxin]

Hello mates,

Who tried 6 bio? I read it's more potent


This article speaks about embryo cells

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031502

It maintain embryo stemcells ? Aren't embryo stemcells similar to hair cells ?

Dr costs speak allot about wnt I guess it's key player in hairlosss

No wnt amino acids equals hair

Not tried bu you can buy it at Kane !

[It's2014ComeOnAlready]

SM could really be the real deal. Setipiprant may not even be necessary if this turns out to be successful, or it would be a matter of topical vs oral medication.

Published in 2013, titled: "Tuning WNT Signals for More or Fewer Hairs" - http://www.nature.com/jid/journal/v1...d2012446a.html

"Abnormal hair development and regeneration has been implicated in diseases of the skin (e.g., hirsutism, alopecia) and in open wounds when hair follicles are eliminated completely. To manage these clinical conditions, it is important to understand molecular pathways that regulate the number, size, growth, and regeneration of hair follicles. Wnt signaling has a fundamental role in this process. We need a deeper understanding so that we can reliably adjust Wnt levels in existing follicles. In sum, the studies reviewed here have future translational value for skin regeneration following severe wound injury and in the context of tissue engineering. Tuning the levels of Wnt ligands can modulate the number and growth of hairs directly. On the basis of this new knowledge, we now know that Wnt activity can be modulated by adjusting the secretion of Wnt ligands, altering binding of ligands to receptors, inhibiting β-catenin translocation, or by regulating extrafollicular dermal Wnt and Wnt inhibitors."

[champpy]

I was also asked to come in and be evaluated as a candidate for CB trial at a clinic in Austin TX. This was only two months ago. The woman I spoke with mentioned that if I changed my mind and wanted to participate that I could get a hold of them later. I found this odd because I thought trials had "start dates", but apparently the CB trial has been ongoing and will continue to add people as time goes on

[KO1]

I assume that for trials, not everybody starts at the same date, so a six month trial may well take q year.

[BiqqieSmalls]

I was also asked to come in and be evaluated as a candidate for CB trial at a clinic in Austin TX. This was only two months ago. The woman I spoke with mentioned that if I changed my mind and wanted to participate that I could get a hold of them later. I found this odd because I thought trials had "start dates", but apparently the CB trial has been ongoing and will continue to add people as time goes on

This coincides with 2014's thoughts on Bim's recruiting process.

Why wouldn't you participate in the CB trial?

[It's2014ComeOnAlready]

I'm just appreciative that companies with excellent backing are trying to tackle this problem from every known angle: WNT, PGD2, PGF2a, and chemicals with anti-androgenic properties without the side effects.

One, if not all of these are bound to work.

[burtandernie]

Does anyone else find it odd what a coincidence it is that shortly after propecia went off patent that all these other things popped up?
Anyhow though I think the future for MPB in another 5 years will be different than it is now. It will be much easier to prevent and stop with much less risk

[It's2014ComeOnAlready]

Does anyone else find it odd what a coincidence it is that shortly after propecia went off patent that all these other things popped up?

Definitely not odd or a coincidence. It is the power of the almighty dollar.

[BiqqieSmalls]

Definitely not odd or a coincidence. It is the power of the almighty dollar.

How would Propecia's expired patent affect the occurrence of other products?

[champpy]

This coincides with 2014's thoughts on Bim's recruiting process.

Why wouldn't you participate in the CB trial?

Well I live in Dallas and the trial is in Austin. Theres always the possibility that I might get the placebo and I don't want to make the 3 hr drive each month for a placebo.

I am also afraid that if I get the actual CB, and it works to retain my hair, what happens after I stop the 6 month treatment? Would my hairloss continue at an accelerated rate? I still have enough hair to cover the thinning areas. I cant afford to have it fall out even faster after discontinuing CB.

[It's2014ComeOnAlready]

How would Propecia's expired patent affect the occurrence of other products?

Means people could now buy generics, and none of that money goes to Merck. There is also no longer a brand name drug dominating the hair loss market, of which has only skimmed the surface. A new brand name drug that doesn't have sexual side effects and could potentially also used by women, would suck up most, if not all of the market. It would be a true slam-dunk in the pharma industry. Billions of dollars and untold potential.