Sm04554

[Seuxin]

I wondered if anyone already tried the wnt agonist selled on TheKaneShop nammed 6-bio ? It's cheap....but i don't know the amount to use ! Anyone have informations about this ?

[dm90]

I typed "Wnt pathway" on Google and all this stuff is related to cancer. It's scary to know SM04554 is dealing with this, how can we know if this can provok cancer after 5/10 years of using this?

They can look for Histological changes from the biopsies, there are pretty obvious signs on a histological level if a compound can lead to cancer. Dont start worrying about potential cancer for a drug that hasnt even been approved yet, If it gets to that point chances are its safe. I was merely saying thats probably what the extended biopsy trials are for.

[Hemo]

How about we let the professionals decide if this might cause cancer? The only way to be sure if it does so 5-10 years down the line is to wait that long, and I don't think anyone sees that as realistic.

If you're worried about the risks if/when this comes to market, then don't take it. I highly doubt a company whose treatments revolve around the wnt pathway are unaware of the potential risks (and I doubt they want to ruin their careers). I'm not someone who blindly trusts but it seems to be common knowledge that manipulating the wnt pathway can cause cancer; I don't think they'd be doing what they're doing without knowing ways to limit/eliminate that risk.

[stayhopeful]

Guys, I just glossed over some of the comments here and look at what you are saying from a different perspective.

Balding is one of the worst things in the world. Don't compare it to cancer. And don't say you would trade hair in 20s for cancer 10 years later, that is one of the dumbest things i've ever heard. It's a free world you can think that if you want, but i'll tell you right now you need to be a little smarter than that. I am inyoung too so I know what the feeling is. Work on some other stuff , this year a de facto cure will be found; there is way too much stuff out there it's about to explode. There will be a way to maintain hair with no side effects and hopefully improved surgical methods like pilofocus and anything else with regeneration

[stratowich]

I would take cancer in 10 years in exchange for hair now. I would do almost anything to be able to enjoy my 20s.

Choose your words more wisely mate. Pretty much every person having cancer would rather be bald than go through chemotherapy, radiation treatment, surgery or the fears of actually dying from the illness (which many people do in the long haul)

You don't need hair to enjoy your 20s!

[Follisket]

Hair loss is cancer.

[iaskdumbquestions]

I would take cancer in 10 years in exchange for hair now. I would do almost anything to be able to enjoy my 20s.

[Seuxin]

kim889, stop being silly....Trust scientist and doctors....it's their job...If a drug need a lot of time to be approval it's not for nothing...

[kim889]

I typed "Wnt pathway" on Google and all this stuff is related to cancer. It's scary to know SM04554 is dealing with this, how can we know if this can provok cancer after 5/10 years of using this?

[dm90]

In addition, there was already a press release saying they were successful in modulating the WNT pathway for their osteoarthritis trial, so that's good news, they can actually do what they theorized, for osteoarthritis at least

[dm90]

The results will more than likely not be posted until after the extended trials are complete in April. Remember they still have to collect and analyze all of the data. I really doubt they are going to rush out the results while the trial is still ongoing. Hellouser already interviewed them and they didn't have much to say. However the interest has been made known to them so I really think that "milking" them would be a waste of time. These guys are drug developers and they will out out the results when they're ready. Just be patient, take a break from the forums. Personally I think that the extended trials are just to monitor the potential for cancer. They aren't going to rush out a drug that could potentially tank their entire company. Personally I am very excited about the potential of this drug, it would be a growth stimulant that we actually know how it works, unlike minoxidil. The science is very sound too.

[Tomtom21]

@nameless my dude like you Im dying from the suspense of awaiting sm trial results. Im doing my best to keep things in perspective because Id rather have expectations surpassed rather than let down. However, they even came out in that last press release from december making big claims (but again could just be a media blitz for attention/warrant interest in the company). Anyways, I did some digging into that conference they allegedly will be at in march. They will be there and yazici & co will have an eposter presentation. Unfortunately, from what their abstract states it will be basically everything they presented at WHC in november (the phase I study). We need someone to attend so lets get the word out that whoevers local needs to try and milk out some answers for the greater good.
Btw here is the link to their abstract for the upcoming congress:

https://www.aad.org/eposters/view/Abstract.aspx?id=3299

[nameless]

I think it would be an eventual meeting for samuned ! What do you think dude ?

I don't know for sure yet but but since they were there last year it does seem possible. I hope we can get someone to go.

One thing though is that it looks to me like their supplemental phase 2 will end in April not March.

[iaskdumbquestions]

I live in DC, but as my username suggests, I'd probably ask dumb questions.

[noisette]

And as you can see, Samumed was a coporate supporter of this event on 2015

http://nahrs.org/MeetingsCalendar/ArchiveofNAHRSEvents/tabid/120/Default.aspx