Local Antiandrogen Therapy for the Treatment of Male Pattern Baldness

[burtandernie]

It could act differently then a normal AA like propecia if you read the article. We only need one good safe topical AA whether this or CB to basically make MPB a preventable problem. Why its taken 20 years to get something like this since propecia I really dont know but better late then never

page 3 bright green letters
"By inhibiting androgen and PGD2 synthesis nitric
oxide may have multiple mechanisms that can be exploited to treat male pattern baldness."

[kobefan234]

Good for them, because taken orally it can screw you up pretty good!

yes, most dermatologists will have you believe that, giving 80 mg to a 150lb teen kid for sure "screw you up pretty good!". LOL

Reading about the side effects, isotretinoin looks pretty scary

when given in high amounts yes. The dose is dependent on body-weight. isotretinoin used at 20 mg per day for 5-6 months is a cure for acne for 95 % + people.

Low-dose isotretinoin in the treatment of acne vulgaris.
Amichai B, Shemer A, Grunwald MH.
Source
Huzot Clinic of Clalit Health Services, Ashkelon, Israel.
Abstract
BACKGROUND:
The efficacy of isotretinoin at 0.5 to 1.0 mg/kg per day in the treatment of acne is well established and considered safe, although it is sometimes not easily tolerated because of its cutaneous side effects.
OBJECTIVE:
The purpose of this study was to determine the efficacy of low-dose isotretinoin in the treatment of acne.
METHODS:
In this prospective, noncomparative, open-label study, 638 patients, both male and female, with moderate acne were enrolled and treated with isotretinoin at 20 mg/d (approximately 0.3-0.4 mg/kg per day) for 6 months. The patients were divided into two age groups: 12 to 20 and 21 to 35 years old. Patients were evaluated at 2-month intervals by means of clinical and laboratory examinations. A 4-year follow-up was also carried out.
RESULTS:
At the end of the treatment phase, good results were observed in 94.8% of the patients aged 12 to 20 years, and in 92.6% of the patients aged 21 to 35 years. Failure of the treatment occurred in 5.2% and 7.4% of the two groups, respectively. Twenty-one patients dropped out of the study because of lack of compliance, and another patient discontinued participation because of a laboratory side effect. During the 4-year follow-up period, relapses of the acne occurred in 3.9% of the patients aged 12 to 20 years and in 5.9% of the patients aged 21 to 35 years. Elevated serum lipid levels (up to 20% higher than the upper limit of normal value) were found in 4.2% of the patients and abnormal (<twice the upper limit of normal values) liver tests were observed in 4.8%.
LIMITATIONS:
This was a noncomparative, open-label study.
CONCLUSION:
Six months of treatment with low-dose isotretinoin (20 mg/d) was found to be effective in the treatment of moderate acne, with a low incidence of severe side effects and at a lower cost than higher doses.

[hellouser]

isotretinoin = cure for acne.

most dermatologists refrain from prescribing it.

Reading about the side effects, isotretinoin looks pretty scary

[youngin]

isotretinoin = cure for acne.

most dermatologists refrain from prescribing it.

Good for them, because taken orally it can screw you up pretty good!

[kobefan234]

I really doubt that. There are so many existing treatments for acne its disgusting.

How many treatments are there for hair loss?

A WHOPPING TWO!

isotretinoin = cure for acne.

most dermatologists refrain from prescribing it.

[hellouser]

nice so we have 3 companies developing topical antiandrogens.

sucks tho that by the time you can buy them ill be bald as a cueball.

Mash up Finasteride pills into a vehicle of your own then.

[LMS]

nice so we have 3 companies developing topical antiandrogens.

sucks tho that by the time you can buy them ill be bald as a cueball.

[Tenma]

http://www.hygeiatherapeutics.com/portfolio.html

The name of the compound is HYG-102440.

This company was recently acquired by Stratus Media:

http://www.businesswire.com/news/rxtimes/20131121005398/en/Stratus-Media-Group-Completes-Acquisition-Biopharmaceutical-Companies

Unlike Histogen, they move forward with the merger.

Also, here you have the CB study showing amazing numbers:

http://www.cosmopharmaceuticals.com/news/press/pr2010/2010-10-06.aspx

[beetee]

This does seem interesting. Tenma, I haven't seen the part talking about developing a formula with estrogen. Can you tell me where that's coming from? And could someone let me know where the 50% regrowth number is coming from?

[Thinning87]

I think it has potential. Could be better than current antiandrogen therapy, which can regrow some hair, by the way.

Not much, thats true but using a topical antiandrogen with Fin/Dut (have been taking it with good results since 5-6 years) could do a lot in terms of prevention.

Maybe in a not so distant future people could use these in conjuction with CB and get even more decent results.

I'm a nw 2. something right now, obviously this kind of treatment wont do much if you are a norwood 7.

Right,but you will be nw7+ when this comes out

[Tenma]

Bring this up cuz it could reach the market before CB or Hygeia. As you may know, this last company is developing a drug that combines an antiandrogen with a side effects free topical estrogen. Without any doubts a very, very promising approach. I recall Cots highliting last year the hair regrowth potencial of estrogen. But safety has always been (and still is) a huge concern.

[hellouser]

Acne is much larger market then MPB that is why they are all over that first. Lots of women and men have that so much larger market.

I really doubt that. There are so many existing treatments for acne its disgusting.

How many treatments are there for hair loss?

A WHOPPING TWO!

[Tenma]

Even if the the numbers change a bit with other vehicle, locally applied side effects free antiandrogen therapy with things like Pilofocus, will really change our situation.

[hellouser]

Yeah, might be a reason. But there are so much money to make on the mpb field...



Totally agree with you on this. Having more than one viable option (oral antiandrogens) for prevention is a BIG thing. Also CB numbers with io were pretty decent in terms of regrowth.

The CB numbers with iontophoresis weren't decent, they were flat out amazing. 50% increase is huge.

[Tenma]

"Acne is much larger market then MPB that is why they are all over that first. Lots of women and men have that so much larger market."

Yeah, might be a reason. But there is so much money to make on the mpb field...

In another 5 years with something like this, CB, existing treatments such as fin I think MPB will be preventable. You wont regrow all your hair but those treatments should stop MPB cold which is a big leap forward on its own.

Totally agree with you on this. Having more than one viable option (oral antiandrogens) for prevention is a BIG thing. Also CB numbers with io were pretty decent in terms of regrowth.