wtf is going with HISTOGEN phase 2b?

[Scientalk56]

Does anyone know the current status of Histogen? Are they still moving forward?

for now, they're dead. they were supposed to start phase 2b a year ago.

[Imalmostbald]

I wouldnt be surprised if it we're in the micrograms. But yeah, it would concern me too. I suppose this is something we'd need to find out from Histogen....

They secret the growth factors from fibroblasts and they ain't e.coli derived. You need a lab with proper equipment to replicate them, its not hard to do it though. But on the other hand their results are shit.

[hellouser]

Potential dosage related issues, of course. They even publicly announced there is a toxicity factor at certain doses. Why would you test it on yourself without even knowing with certainty how much your body can tolerate

I wouldnt be surprised if it we're in the micrograms. But yeah, it would concern me too. I suppose this is something we'd need to find out from Histogen....

[Thinning87]

If Histogen is using WNT7a, why wouldnt you yourself?

Potential dosage related issues, of course. They even publicly announced there is a toxicity factor at certain doses. Why would you test it on yourself without even knowing with certainty how much your body can tolerate

[Javert]

Does anyone know the current status of Histogen? Are they still moving forward?

[hellouser]

Wouldnt ****k around with that stuff

If Histogen is using WNT7a, why wouldnt you yourself?

[Thinning87]

Bought it.. There are some biology research companies who carry it, although very expensive.

Personally I don't know to what paper you are referring to.. But no it surely isn't as simple as getting wnt7a injecting it with wounding and creating de novo hair follicle neogenesis. Idea of follica is to induce neogenesis with wounding through wnt expression indeed. But they are surely still very far away from that. They never proved anything till date.

Wouldnt ****k around with that stuff

[hellouser]

Bought it.. There are some biology research companies who carry it, although very expensive.

Personally I don't know to what paper you are referring to.. But no it surely isn't as simple as getting wnt7a injecting it with wounding and creating de novo hair follicle neogenesis. Idea of follica is to induce neogenesis with wounding through wnt expression indeed. But they are surely still very far away from that. They never proved anything till date.

Follica is supposed to rely on FGF-9, not WNT7a. WNT7a is Histogen's method.

[Imalmostbald]

Bought it.. There are some biology research companies who carry it, although very expensive.

Personally I don't know to what paper you are referring to.. But no it surely isn't as simple as getting wnt7a injecting it with wounding and creating de novo hair follicle neogenesis. Idea of follica is to induce neogenesis with wounding through wnt expression indeed. But they are surely still very far away from that. They never proved anything till date.

[saintsfan92344]

I have personally done WNT7A E. Coli derived, not injected but with heavy dermarolling in conjunction with SHH, noggin, FGF-2. Did not work really.

How and where did you get that done? I was just reading a little about wnt7 proteins and they say if introduced before scarring it grows hair, isn't that the cure basically?
I am sure that's been discussed, I am not up to snuff on all the science but am trying to learn

[Imalmostbald]

I have personally done WNT7A E. Coli derived, not injected but with heavy dermarolling in conjunction with SHH, noggin, FGF-2. Did not work really.

[cookies]

AND NOW THE BIG QUESTION:

How does one get their hands on WNT7a!?

I wanna see what happens when skin is wounded with, say, dermarolling and then WNT7a injected into the scalp.

Introduce the WNT7a gene trough genetic recombination in cells, let them express the gene, isolate and purify the protein and you're done.

[Kiwi]

Alright, getting tired of reading about speculation and 'researchers' flapping their gums about '5-10 years' bullshit. Lets get down to some business...

From this link:

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0076883

Which is backed by this article:

http://www.nature.com/nature/journal/v447/n7142/full/nature05766.html

AND NOW THE BIG QUESTION:

How does one get their hands on WNT7a!?

I wanna see what happens when skin is wounded with, say, dermarolling and then WNT7a injected into the scalp.

What about that guy who posts here who is a science student???

[hellouser]

Alright, getting tired of reading about speculation and 'researchers' flapping their gums about '5-10 years' bullshit. Lets get down to some business...

From this link:

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0076883

For example, inhibition of the Wnt pathway by ectopic expression of Dkk-1 does not retard skin wound healing, but overexpression of Wnt7a promotes the induction of new hair follicles within the wound bed [14], which is typically referred to as “scarless” healing [16].

Which is backed by this article:

http://www.nature.com/nature/journal/v447/n7142/full/nature05766.html

AND NOW THE BIG QUESTION:

How does one get their hands on WNT7a!?

I wanna see what happens when skin is wounded with, say, dermarolling and then WNT7a injected into the scalp.

[blmars french]

that if we are not there a date for the start of the Phase 2b?

mergers or not the company it is or?

ça nous pas si il y a une date pour le debut de la phase 2b ?

les fusions ou pas de l'entreprise ça en est ou ?