(CB-03-01 Vehicle Research) PhD Student in Chemistry

[hellouser]

People is excited because, for low norwoods it would mean the closest thing to a cure. You see, CB is four times more powerful than finasteride, but it has no side effects.

Fixed.

[Hairismylife]

Hellouser you got result from RU, you really quit it?

[hellouser]

Hellouser you got result from RU, you really quit it?

I quit using it in May, I had about 1gram or less left. My libido was low.

Right now I'm trialing the dermarolling study and do not want RU to go systemic as wounding the skin with the dermaroller will allow much easier penetration. I took 100mg of RU in 1ml about a week ago and I've since experienced twitching in my testicles and a feeling of them being slightly squeezed. I've had similar symptoms over a year ago but I was NOT dermarolling then and only using about a 10mg of RU in 1ml of isopropanol/PG.

I don't want to have RU go any more systemic than what it already may have. CB should be far superior without any side effects.

[adam k]

Based on the structure of CB 03 01, I came across using DMSO as a potential solvent to dissolve it in and also it appears to be a well established vehicle in the medical world. I came across DMSO BEFORE I searched google and found out that there already existed threads with people apparently using DMI/DMSO as a vehicle. What were the outcomes as theoretically this should work.

http://www.google.com/patents/US4177267

http://www.dmso.org/articles/information/herschler.htm

http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1967.tb34906.x/pdf

http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1967.tb34904.x/pdf

DMSO also has other benefits such as anti inflammatory propeties etc which are all a plus.

[adam k]

This is an interesting thread about people experimenting with DMSO. It appears a high concentration gives negative effects.

http://www.regrowth.com/hair-loss-forums/topic/using-dmso-as-a-penetration-enhancer/

An interesting comment:

'Facsinating point on applying the DMSO first, Kingpin, however…at what percentage? You can’t go tossing 99.9% right on the scalp. Perhaps make a 10% DMSO/distilled-water solution?<<<< I’ve used the 70% dmso/aloe gel before without any burning but I dont apply it every day either.Here is a book which gives some insight to what concentration dmso is effective at.Compare the 40% dmso/alcohol vs just plain alcohol.Huge difference.I suppose a liquid dmso(99% pure) could be used as a co-vehicle with alcohol at a 60-40 ratio(60% ethyl alcohol-40% dmso). http://books.google.com/books?id=4M7...iCPP73k1g9QT3M Another benefit(in above book) is that DMSO deposits the drug into the skin where it is still found days later! This is ideal since there would always be at least some active substance hanging around the hair follicle acting as a time released treatment of sorts.Also,this could be looked at as a way to incorporate more topicals into the rotation scheme because each one doesnt have to be applied daily… DMSO also works to increase penetration of both hydrophilic and hydrophobic substances.What more can you ask…and its cheap.'

[lilpauly]

If water is no good then why in the following paper:

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2011.10332.x/pdf

has water been used? This leads me onto the next question. Apologies if it's been answered before but I am new to this research and just starting.

The above paper mentions a CB-03-01 1&#37; cream (cetyl alcohol, glyceryl
monostearate, liquid paraffin, propylene glycol, tocopherol,
sodium edetate, polysorbate 80, water). If this has been used in the study then why can't this be used on the scalp such as on the receding hairline?



This is what I'd like to see happen. As you rightly said it would me a massive F U to the entire industry who are taking the P with their snail pace research, not to mention the FDA which is a joke.

I started some research last night and came across:

http://www.google.co.uk/patents?hl=en&lr=&vid=USPAT5041439&id=0V4fAAAAEBAJ&oi=fnd&dq=solvent+scalp+penetration&printsec=abstract#v=onepage&q=solvent%20scalp%20penetration&f=false

this suggests a small diol/triol mixed with a long chain alcohol i.e whats already been mentioned propylene glycol/oleyl alcohol? Was this used by anyone?

I am computing properties of cb-03-01 today and based on properties such as ClogP for example and other parameters I will be doing some more research today on suitable vehicles, in my limited time (I have major deadlines in my other work!)

the cream was used for acne and not hair, ingredients no good for hair

[adam k]

the cream was used for acne and not hair, ingredients no good for hair

How about using DMSO as a composition of the vehicle lilpauly? Has this been tried?

[lilpauly]

todah rabah! How about using DMSO as a composition of the vehicle lilpauly? Has this been tried?

Yes approx 100- 150 used it 2 years ago rwsts were Terrible. It works amazing for the face . It also cost 320 per gram back then on stopmpb ( mpb treatments)

[lilpauly]

*^ was for the cream

[adam k]

Yes approx 100- 150 used it 2 years ago rwsts were Terrible. It works amazing for the face . It also cost 320 per gram back then on stopmpb ( mpb treatments)

It seems to me that results and reports for different vehicle concentrations and compositions of CB are too vague and scattered and not objective enough. Results need to be collated in one thread with all different combinations of vehicles and reasons for their failure. Regarding the DMSO trial why were results terrible? Terrible as in adverse reactions to the vehicle or simply not a correct vehicle chemically? And how long do people carry out these trials and what do they define as success?

[tornadox]

If you can actually do this. You could be come a millionaire.

[lilpauly]

It seems to me that results and reports for different vehicle concentrations and compositions of CB are too vague and scattered and not objective enough. Results need to be collated in one thread with all different combinations of vehicles and reasons for their failure. Regarding the DMSO trial why were results terrible? Terrible as in adverse reactions to the vehicle or simply not a correct vehicle chemically? And how long do people carry out these trials and what do they define as success?

No man no1 used DMSO only cream 2 years . We used Cosmo acne cream and it very bad

[Borealis]

If you can actually do this. You could be come a millionaire.

No you couldn't because it's patented by COSMO.

[adam k]

If you can actually do this. You could be come a millionaire.

Money needs to be left out of this (in this case you couldnt as its patented by COSMO). The solution is going to come from amongst ourselves and I think I speak for everyone when I say we all want something to JUST WORK for this god forsaken disease that haunts us every waking hour.

The difference between these forums and industry is that we are a community and working for each other just as much as ourselves. We are a community who all want the same thing. And in the instance a vehicle is found for cb that works, then this must be kept within the forums as there will be all kinds of negative issues that arise and people who will want this to be stopped just because they cant stand the fact that WE DID IT OURSELVES.

[adam k]

No man no1 used DMSO only cream 2 years . We used Cosmo acne cream and it very bad

Yeah I see. Then DMSO needs to be looked into further. There is a thread over on another forum regarding this:

http://www.hairlosshelp.com/forums/messageview.cfm?catid=7&threadid=103957

but the thread went stagnant. Maybe there is some merit to using DMSO as part of the composition of the vehicle. I shall look into this more.