(CB-03-01 Vehicle Research) PhD Student in Chemistry

[rdawg]

We could end up using a vehicle which affects the CB composition, rendering it useless, we don't want that to happen.

CB is not so cheap you know?, trying in every vehicle would take much money, which I'm sure not many around here are willing to risk.

Even worse, trying every vehicle would take a lot of time.

alright alright makes sense.

I agree, but obviously these tests are meant for someone who has some cash to spare.

Either way, what are our top candidates for vehicles adam? Can we test solubility and penetration?

why not start with the obvious ones like ethanol?

[adam k]

Either way, what are our top candidates for vehicles adam? Can we test solubility and penetration?

why not start with the obvious ones like ethanol?

Propylene Glycol/Oleyl Alcohol
and the one by Iron Dragon PG/Ethanol. I also think something like this is promising http://phfsupplements.com/salvo-presale.html

I've realised in my previous post there are some vehicles that arent suitable for a liquid solution (as that is what we are after) as they are for a cream formulation. I'll amend the post in a bit.

Also derma rolling should make any absorption even better. It is promising stuff. I am going to start derma rolling myself soon.

[UK_]

PG/Ethanol should be fine its worked well for practically everything else.

Adam what do you think about the side effects profile for CB? The fact that it converts into a benign substance once in the bloodstream? Do you think side effects are completely avoidable with CB due to this?

[GuyFromUK]

The key to the puzzle of which vehicle to use will be held by someone working for Cosmo. The pharmacists working at Cosmo will have a far better idea than anyone on the forums on whether a) CB actually works for hairloss, and b) which vehicle to use

If people on the forums really want to go to any length to solve hairloss then why not have 1 person fly out to the Cosmo office. If you wait outside their office at the time they all finish work then we can ask their staff directly about their thoughts on using CB for hairloss. I am sure a little brown envelope with a thousand dollars cash in would be enough to encourage someone working there to tell us everything we need to know.

Any volunteers?

[NeedHairASAP]

The key to the puzzle of which vehicle to use will be held by someone working for Cosmo. The pharmacists working at Cosmo will have a far better idea than anyone on the forums on whether a) CB actually works for hairloss, and b) which vehicle to use

If people on the forums really want to go to any length to solve hairloss then why not have 1 person fly out to the Cosmo office. If you wait outside their office at the time they all finish work then we can ask their staff directly about their thoughts on using CB for hairloss. I am sure a little brown envelope with a thousand dollars cash in would be enough to encourage someone working there to tell us everything we need to know.

Any volunteers?

lol, probably a stretch. Somebody should just call their marketing dept posing as a reporter looking to give them PR.

like some chemist making 80-130k is going to risk getting fired for a thousand bucks in an envelope.

[hellouser]

The key to the puzzle of which vehicle to use will be held by someone working for Cosmo. The pharmacists working at Cosmo will have a far better idea than anyone on the forums on whether a) CB actually works for hairloss, and b) which vehicle to use

If people on the forums really want to go to any length to solve hairloss then why not have 1 person fly out to the Cosmo office. If you wait outside their office at the time they all finish work then we can ask their staff directly about their thoughts on using CB for hairloss. I am sure a little brown envelope with a thousand dollars cash in would be enough to encourage someone working there to tell us everything we need to know.

Any volunteers?

Lets suppose we even did try to take the illegal route of bribery:

1) Their location for the clinical trials for CB may be in a different locale
2) How would we know that the vehicle released by someone would be legitimate. It would take months before the results could be verified by others using Kane's or Iron Dragon's CB.

[greatjob!]

The key to the puzzle of which vehicle to use will be held by someone working for Cosmo. The pharmacists working at Cosmo will have a far better idea than anyone on the forums on whether a) CB actually works for hairloss, and b) which vehicle to use

If people on the forums really want to go to any length to solve hairloss then why not have 1 person fly out to the Cosmo office. If you wait outside their office at the time they all finish work then we can ask their staff directly about their thoughts on using CB for hairloss. I am sure a little brown envelope with a thousand dollars cash in would be enough to encourage someone working there to tell us everything we need to know.

Any volunteers?

They'd loose their job and probably be sued, so I doubt anyone that has that knowledge at Cosmo would risk their no doubt very large salary and benefits package for $1000 or to help some balding stranger.

[NeedHairASAP]

yeah plus you just committed conspiracy to commit corporate espionage.

[hellouser]

They'd loose their job and probably be sued, so I doubt anyone that has that knowledge at Cosmo would risk their no doubt very large salary and benefits package for $1000 or to help some balding stranger.

Would only happen if they got caught.

I have no hopes for this though to even happen, i'd consider it as a final attempt/hail mary but the sum would need to be a LOT higher than $1,000.

[GuyFromUK]

Haha, I don't think you would be breaking the law if you paid someone to tell you if their product works for hairloss. It's not like I would be using the information for a competing company.

Just to clarify though I am not really going to fly to the Cosmo office with a back pocket full of dollars, the post was a bit tongue in cheek.

[hellouser]

Haha, I don't think you would be breaking the law if you paid someone to tell you if their product works for hairloss. It's not like I would be using the information for a competing company.

Just to clarify though I am not really going to fly to the Cosmo office with a back pocket full of dollars, the post was a bit tongue in cheek.

You'd definitely be breaking on contract of confidentiality with Cosmo Pharmaceuticals. You can be sure as hell they would take you to court for that and make you cover any and all damages by your actions.

[adam k]

PG/Ethanol should be fine its worked well for practically everything else.

Adam what do you think about the side effects profile for CB? The fact that it converts into a benign substance once in the bloodstream? Do you think side effects are completely avoidable with CB due to this?

Well we know that CB-03-01 competes at the androgen-receptor level without inhibiting the skin 5AR-reductase. Therefore as only the receptors are blocked DHT is still free to go around and do what else it does but it just cant bind.

The steroid easily penetrates human skin (said by Cosmo) and is quickly and extensively metabolized to free inactive cortexolone by enzyme catalysed hydrolysis (see scheme):



thus being devoid of systemic antiandrogenic effects. I'm not sure (so somebody correct me if I'm wrong) but I think the drug makes its way through the skin and those that reach the receptors in the active form bind and block DHT from binding. Then it stays there for however long, unbinds and when it comes into contact with an enzyme it is metabolised to cortexolone.

The toxicological profile showed that CB-03-01 is well tolerated in rat and rabbit in repeated subcutaneous and dermal toxicities, is not mutagenic (I have ran numerous crude simulations to confirm it is not mutagenic), and is not a skin sensitizer (Theres been concerns of skin atrophy but wouldnt have Cosmo picked this up?) . In adult male volunteers a single skin application of various volumes of CB-03-01 1% cream was very well tolerated with negligible absorption in the bloodstream. Even were it to reach the bloodstream it would be converted to its inactive form I think. And lets just say it binds to a receptor elsewhere in the body (I dont know if this is even possible, I'm just guessing here) then wouldnt it just dissociate after a while and get converted to an inactive form? Also a very small amount would reach this far if it did and there are numerous receptors so I don't think this would be significant.

[mari0s]

If people on the forums really want to go to any length to solve hairloss then why not have 1 person fly out to the Cosmo office. If you wait outside their office at the time they all finish work then we can ask their staff directly about their thoughts on using CB for hairloss. I am sure a little brown envelope with a thousand dollars cash in would be enough to encourage someone working there to tell us everything we need to know.

Any volunteers?

1) This is incredibly racist, people have passion for their work, you know? Not everyone sell his dignity for a bunch of money

2)Nobody cares of you dollars since euros is 30% more valued

3)If you really want, you can fly yourself, Milan is just an 1hr away from UK but you need to hurry up for your return flight before the police arrest you for bribery

[greatjob!]

1) This is incredibly racist

Uh i think it was a stupid idea, but I fail to see how his idea was racist.

[hiilikeyourbeard]

please stay on topic