(CB-03-01 Vehicle Research) PhD Student in Chemistry

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  • lilpauly
    Senior Member
    • Feb 2012
    • 1084

    Originally posted by cookies
    In Cosmo's presentation from november they mentioned amendements in their cb trails due to a change in formulation (http://www.cosmopharmaceuticals.com/...Healthcare.pdf see p29).

    Was this already know? I haven't seen anyone discussing it here.
    Great find!!! A change to what though ? Vehicle ?

    Comment

    • doke
      Senior Member
      • Jun 2009
      • 1464

      It also looks that cb is a long way ahead until it comes available for any of us, i notice that it comes in the cyproterone and flutamide bracket and we know that them too are systemic which is what the sintov study of flutamide used a topical gel that only worked at the hair follicles with little side effects.
      And i still wonder why we never got that on the market it maybe down to cost of the trials on humans and thats why mpb and all forms of alopecis suck because its not important for drug companies to concentrate on alopecia unless they know they can afford the trials and get fda and world approval and make a lot of money from it.
      I mean we in uk have new drugs for cancer and other life saving products that are too expensive for our health service to buy and for one its terrible that these drug companies favor profit over life so where does that leave hairloss at the back burner for importance.

      Comment

      • cookies
        Member
        • Dec 2013
        • 39

        Originally posted by lilpauly
        Great find!!! A change to what though ? Vehicle ?
        Actually this presentation was already posted 10 pages ago. The presentation doesn't mention vehicles at all, so i assume they changed the formulation of CB itself.

        Comment

        • cookies
          Member
          • Dec 2013
          • 39

          Originally posted by doke
          I mean we in uk have new drugs for cancer and other life saving products that are too expensive for our health service to buy and for one its terrible that these drug companies favor profit over life so where does that leave hairloss at the back burner for importance.
          They're companies and not charities. If they wouldn't make profit, they'd got bankrupt.

          Comment

          • doke
            Senior Member
            • Jun 2009
            • 1464

            yes they are companies and not charities but where does compassion lie these so called companies charging say £37000 for a drug to save your life how could anybody afford that and thats where even uk nhs has to draw a line.

            Comment

            • itssomuchfun
              Member
              • Feb 2012
              • 34

              Hello,

              I've been a lurker on this forum for a while. Had tried the Rogaine foam and oral minoxidil but have been on nothing for months. Have never wanted to try Fin or Dut. Decided I'd try CB because of the supposed lack of sexual sides involved.

              I just received CB from the ID website (I know many on the forum say the site is a fraud). It comes premixed and when I read all the talk about ordering through Kane and mixing with different vehicles I realized I'd need a small lab of chemicals. So I'm giving this a shot. It's a 30ml in a solution of ethanol and propylene glycol. 10mg/ml. I couldn't find out from reading page after page on this thread how much I'm supposed to use. It's a liquid dropper. Do I measure out 1ml of solution and apply it daily? Do I use 0.5 ml and use it daily? What is the appropriate amount to use? Any suggestions would be appreciated.

              Comment

              • itssomuchfun
                Member
                • Feb 2012
                • 34

                Hello,

                I've been a lurker on this forum for a while. Had tried the Rogaine foam and oral minoxidil but have been on nothing for months. Have never wanted to try Fin or Dut. Decided I'd try CB because of the supposed lack of sexual sides involved.

                I just received CB from the ID website (I know many on the forum say the site is a fraud). It comes premixed and when I read all the talk about ordering through Kane and mixing with different vehicles I realized I'd need a small lab of chemicals. So I'm giving this a shot. It's a 30ml in a solution of ethanol and propylene glycol. 10mg/ml. I couldn't find out from reading page after page on this thread how much I'm supposed to use. It's a liquid dropper. Do I measure out 1ml of solution and apply it daily? Do I use 0.5 ml and use it daily? What is the appropriate amount to use? Any suggestions would be appreciated.

                Comment

                • itssomuchfun
                  Member
                  • Feb 2012
                  • 34

                  Sorry for the double post. I read went back further in this thread and it looks like hellhouser was using a 12.5% concentration of CB in 1.5ml using dropper once a day. Does that cover your entire scalp?

                  Comment

                  • hellouser
                    Senior Member
                    • May 2012
                    • 4419

                    Originally posted by itssomuchfun
                    Sorry for the double post. I read went back further in this thread and it looks like hellhouser was using a 12.5% concentration of CB in 1.5ml using dropper once a day. Does that cover your entire scalp?
                    Incorrect.

                    I'm using anywhere from 15mg to 30mg per 1ml.

                    Comment

                    • doke
                      Senior Member
                      • Jun 2009
                      • 1464

                      Originally posted by itssomuchfun
                      Hello,

                      I've been a lurker on this forum for a while. Had tried the Rogaine foam and oral minoxidil but have been on nothing for months. Have never wanted to try Fin or Dut. Decided I'd try CB because of the supposed lack of sexual sides involved.

                      I just received CB from the ID website (I know many on the forum say the site is a fraud). It comes premixed and when I read all the talk about ordering through Kane and mixing with different vehicles I realized I'd need a small lab of chemicals. So I'm giving this a shot. It's a 30ml in a solution of ethanol and propylene glycol. 10mg/ml. I couldn't find out from reading page after page on this thread how much I'm supposed to use. It's a liquid dropper. Do I measure out 1ml of solution and apply it daily? Do I use 0.5 ml and use it daily? What is the appropriate amount to use? Any suggestions would be appreciated.
                      hi is the id cb greasy and please let us know how you get on with it.

                      Comment

                      • doke
                        Senior Member
                        • Jun 2009
                        • 1464

                        Originally posted by hellouser
                        Incorrect.

                        I'm using anywhere from 15mg to 30mg per 1ml.
                        hi hell how are you getting on with the cb as i heard on one forum of burning scalp.

                        Comment

                        • itssomuchfun
                          Member
                          • Feb 2012
                          • 34

                          Sorry Hellouser for the incorrect info. How many ml are you using? I started using it yesterday and it's impossible to use just 1ml for my entire scalp crown to vertex, at that is what I've found.

                          Doke, I just ordered it from their website. Just google Iron Dragon. It's listed as Cortexolone 17-Alpha Propionate which is supposedly the same thing. I got it in about 10 days. Hopefully some of my hair loss starts to abate in the next month or two because I'm am pretty close to just shaving it off because it's very thin on top it's a few months away from looking pretty silly.

                          Comment

                          • yan
                            Senior Member
                            • May 2013
                            • 156

                            Today`s cosmo-presentation is a bit disappointing...

                            Only info about cb for alopecia is this:

                            Pre clinical:
                            - Pre-clinical development on mini-pigs (6 and 9 months) to obtain the chronic use of the drug;
                            - last tolerability test ongoing

                            clinical:
                            - phase I clinical study in EU completed
                            - PK results: ˂1% API absorption into the blood = topical drug
                            - Phase II POC: design with 3 arms (drug, placebo, comparator), 6 months treatment + follow up, male pts only

                            regulatory:
                            - Pre-IND meeting held on 18 Dec 13, full FDA agreement on development program

                            Comment

                            • TwoInchCircle
                              Junior Member
                              • Jul 2013
                              • 21

                              Originally posted by yan
                              Today`s cosmo-presentation is a bit disappointing...
                              To say the LEAST. The first thing I did this morning was head over to Cosmo's site to check it out and I couldn't believe what I was seeing. At first, I thought it might be an outline to their real presentation, but, sadly, it is the real presentation.

                              I wasn't expecting them to spill all their secrets regarding vehicles and such, but I was expecting a little more information on whether the trials' success and such...

                              Oh well...

                              Comment

                              • LMS
                                Senior Member
                                • Dec 2012
                                • 226

                                straight up, who cares about the alopecia version. when the acne version hits shelves, damn straight we reverse engineering that bitch and making our own super powerful shit.

                                but until then its fin + ru.

                                such is life.

                                Comment

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