(CB-03-01 Vehicle Research) PhD Student in Chemistry

[yan]

And more:

"Considering that finasteride and flutamide were reported to induce a significant inhibition of hamster’s sexual accessory organs after topical application of low dose of about 0.25 mg/kg, and that bicalutamide displayed similar effects in rat after oral administration of 0.4 mg/kg, our data are very impressive and clearly indicate that the topical administration of CB-03-01 should not have systemic effects, on androgen-sensitive organs and functions, even in case of large percutaneous absorption."

[yan]

3) UN-METABOLIZED CB was present in blood plasma of 40% of trialists after application, although in very, very small portions. If someone was extremely susceptible to sides you could argue this small amount could cause them (less than 10 ng/ml). It was fully undetectable 24-36 hours after application in all trialists. However, that said, I am very sensitive to sides and CB's sides were very tolerable in me compared to other meds. I have not used form 3 CB yet, however.

This is true but I just studied the hamster study and it says:

"CB was ineffective as antiandrogen when subcutaneously administered to rats up to a daily dose equivalent about to 100 mg/kg. The observed dissociation between the strong topical antriandrogenic activity and the absence of systemic effect could be explained supposing that, after subcutaneous injection, CB-03-01 undergoes a fast hydrolysis, by the liver or other tissues, leading to the inactive cortexolone form"

However this contradicts the reports from users here. At the moment I have no idea what to do beside waiting for official study results...

[lothar99]

Do you think that depending on the vehicle used, it can cause CB to not metabolize properly and cause sides?

I don't know much about vehicles, but I really doubt that. I mean, a vehicle could cause more or less of the drug to penetrate, and cause it to enter slower or faster. If it pushed it through to blood really fast maybe the body couldn't keep up rate of metabolism or something. Entirely speculation.

[The Dark Knight]

I tried a bunch of stuff to see what caused the least irritation/most immediate effects. various pg/acetone/glycerol or glycerine or something, I forget/ethanol/water in different combinations. I couldn't buy proper ethanol so I used the 70% with water/acetone/additives.

I want to try the form 3 patent cream vehicle or the liposome vehicle. Also want to try the nano vehicle, but nano isn't out yet.

Do you think that depending on the vehicle used, it can cause CB to not metabolize properly and cause sides?

[lothar99]

Lothar what vehicle did you use bro? eth/pg?

I tried a bunch of stuff to see what caused the least irritation/most immediate effects. various pg/acetone/glycerol or glycerine or something, I forget/ethanol/water in different combinations. I couldn't buy proper ethanol so I used the 70% with water/acetone/additives.

I want to try the form 3 patent cream vehicle or the liposome vehicle. Also want to try the nano vehicle, but nano isn't out yet.

[hiilikeyourbeard]

could very well be the wrong vehicle for cb. we need to figure it out

[Cob984]

Lothar what vehicle did you use bro? eth/pg?

[lothar99]

1) Keratene gave me awful sides, though they didn't feel bad in exactly the same as other things I have taken that lowered DHT.

2) RU definitely goes systemic. Pretty much anything you apply topically that manages to reach your hair will also enter your bloodstream. There are an ENORMOUS number of people reporting androgenic sides on RU. There is no way it is all metabolized before reaching androgen receptors in other parts of the body.

3) UN-METABOLIZED CB was present in blood plasma of 40% of trialists after application, although in very, very small portions. If someone was extremely susceptible to sides you could argue this small amount could cause them (less than 10 ng/ml). It was fully undetectable 24-36 hours after application in all trialists. However, that said, I am very sensitive to sides and CB's sides were very tolerable in me compared to other meds. I have not used form 3 CB yet, however.

[Cob984]

I am just very androgen sensitive? How the hell does RU give you sides? it also doesnt interefere with your hormones either in theory, obviously there is systemic absorption, please dont talk trash,

And RU gave me less sides than cb did, much less,
Maybe this is the wrong vehicle who knows,

[locke999]

So, you got sides on CB... even though CB does not interfere with your hormonal chemistry in any way...

And you also had sides on keratene... even though the blood test made by some forum members showed that it did not really worked reducing DHT...

He could be a hypochondriac but I think you shouldn't act as if you know for a fact CB is 100% safe. Even finasteride was thought to be safe but now we know its not.

[chimera]

Well i am never applying Cb ever again in an ethanol/pg vehicle,
My body is slowly coming back to normal, feels like coming off a bad trip,

Even RU was way way more tolerable,

So, you got sides on CB... even though CB does not interfere with your hormonal chemistry in any way...

And you also had sides on keratene... even though the blood test made by some forum members showed that it did not really worked reducing DHT...

[hiilikeyourbeard]

Twat? Lol. Hey douchebag, from reading all his posts, that's my opinion.

If he is going through something emotionally, I have sympathy for him.

Doesn't change how I feel after reading all of his posts.

yeah bro, twat. how would he even be a fraud... he isn't selling anything or trying to deceive people. he's looking for the same info on safety and a vehicle of this compound. don't be a prick

[HairBane]

Hasn't CB already been through acne safety trials? If the side-effects were that bad wouldn't they have binned it by now?

[StayThick]

Well i am never applying Cb ever again in an ethanol/pg vehicle,
My body is slowly coming back to normal, feels like coming off a bad trip,

Even RU was way way more tolerable,

This is extremely disconcerting. Sorry to hear that cob.

[StayThick]

you're a twat, dude. I've had many conversations with Adam in private. he's going through a hard time emotionally right now and I sense that is why he hasn't been around. you're no different calling someone a fraud without knowing him as people are for latching on. assumptions are assumptions

Twat? Lol. Hey douchebag, from reading all his posts, that's my opinion.

If he is going through something emotionally, I have sympathy for him.

Doesn't change how I feel after reading all of his posts.