custom growth factors

[2020]

Factors are safe

hey you still haven't addressed as to why should anyone bother for - at best - 10% increase in hair count which is actually much less than that because it's 10% of your current hair and not original hair. Are there any better studies?

[hellouser]

hey you still haven't addressed as to why should anyone bother for - at best - 10% increase in hair count which is actually much less than that because it's 10% of your current hair and not original hair. Are there any better studies?

It was 29% increase 'at best' and that was for women. Average increase was 10%. Men respond to hair treatment much better than women, you could take a wild guess and assume we could get higher numbers in increase.

[2020]

Men respond to hair treatment much better than women, you could take a wild guess and assume we could get higher numbers in increase.

where did you get that? It's completely opposite of that. Women have much less DHT and much more estrogen - these are all pro-hair growth conditions. Even Gail said that Histogen works "very well" for women versus men.

[Dan26]

2020 keep in mind in the trials this was only used once every 2 weeks, some trialists will be using it weekly or even more often

[lilpauly]

hey you still haven't addressed as to why should anyone bother for - at best - 10% increase in hair count which is actually much less than that because it's 10% of your current hair and not original hair. Are there any better studies?

10% in hair count and 10% in hair thickness thats preet impressive~

results imo, the 2nd one is just a follow-up of the first one and with only 10 applications such results are pretty damn nice. Also take in account those people ain't on a anti-androgen, minox or whatsoever. A combination of growth factors + anti androgen+ minox or so would yield even better results.Also it's well described that using noggin will block bmp4 > induce shh that induces WNT-10B

some people reached 29% regrowth and almost 28% thickening.

[lilpauly]

Can you post the list of ingredients?

they contain VERY VERY Expnsive growth factors like the ones in histogen!

FGF,IGF-1,VEGF,stem cell factors, KGF-1,superroxide dismutase adn Noggin

[hellouser]

they contain VERY VERY Expnsive growth factors like the ones in histogen!

FGF,IGF-1,VEGF,stem cell factors, KGF-1,superroxide dismutase adn Noggin

FGF?

As in... FGF-9? If so, that will never penetrate the skin, its molecular weight is 23,000 dalton. Human skin only allows up to around 500 dalton to pass through it.

[lilpauly]

FGF?

As in... FGF-9? If so, that will never penetrate the skin, its molecular weight is 23,000 dalton. Human skin only allows up to around 500 dalton to pass through it.

I'm not a 100% sure hellouser I will ask Kane , it's a special nano solution vehicle as well

[lilpauly]

Is says just fgf in the trials

[hellouser]

Is says just fgf in the trials

Hmmm... FGF-9 is what Follica is supposedly using to create new hair follicles with wounding. Its very well possible that wounding plus these growth factors COULD lead to growth of hair, but FGF-9 specifically would be key. However, I think it'd work best if injected using a diabetic needle or a mesogun.

[lilpauly]

helluser Basic fibroblast growth factor . its on the webpage

[lilpauly]

what is the nano solution?
As most growth factors in normal situations are very unstable and vehicle wouldn’t penetrate our skin, we’ve encapsulated them in nano particles.
These little particles carry the growth factors past the epidermal layer.


How long are the growth factors stable?

Whereas growth factors are normally stable for a limited period of time we made sure ours are extremely stable in the specialized nano vehicle.
The Nano solutions are stable for 3 months at room temperature, however, once received, we recommend the solutions refrigerated at 2-8 Celsius. Under those conditions the solution should be stable for a minimum of 12 months

[StayThick]

This sounds extremely interesting....

Any concern for cancer of any kind? That's my only hold up with this.

[Boldy]

This sounds extremely interesting....

Any concern for cancer of any kind? That's my only hold up with this.

sounds like more than a valid question to me. I have ordered this btw, Tracking it says shipping from UK. so it should be here any day or so..



regarding this study, they show what happens when FDA approved more than 100 higher dosed gfs than found in cosmetics, and that on ulcers etc (open wounds..)

regarding this publication, they don't seem concerned about a balanced low dosed gfs.

http://www.gvi.com.mx/Skinmedica/Publicacion%20JDD%20sobre%20Factores%20de%20Crecimiento%20Humano%20Mayo%202009.pdf

Potential Risks of Growth Factors
Growth factors are key to the control of cellular proliferation
and differentiation and, if unregulated, could mediate carcinogenic transformation of cells. The presence of receptors for
some GFs on melanoma cells and the expression of certain
GFs by cancerous cells55have raised concerns about the potential for topically applied GFs to stimulate carcinogenesis. The
effects of receptor presence or their increased expression on
tumor cells are not yet defined. However, a recent FDA investigation suggests that chronic administration of high concentrations of recombinant PDGF directly into debrided diabetic pressure wounds may result in increased mortality from various
types of malignancies that were remote from the site of treatment.56 The prescription product that was the subject of this
FDA investigation contains a more than 1 million-fold higher
concentration of PDGF than the highest levels detected in topical cosmeceutical products. In addition, the prescription prod
uct is applied directly to dermal tissue of a debrided wound,
bypassing the epidermal barrier. It appears unlikely that effects
observed after applying an extremely high concentration of a
single, unbalanced growth factor directly to the dermis can be
extrapolated to a topical cosmeceutical product, containing a
physiological balance of growth factors applied to essentially
intact epidermis. The effects of a physiologically balanced mixture of multiple GF are proposed to be restorative, rather than
therapeutic, in nature. One could also propose that the use of
a physiologically balanced GF mixture, rather than individual
unopposed GFs, might reduce or eliminate the risk of uncontrolled cell growth. We believe that the levels of GFs in skin after
application to the epidermis are not significantly higher than
are those following pro-inflammatory events such as chemical
peels, laser resurfacing or skin infections.

[rdawg]

sounds like more than a valid question to me. I have ordered this btw, Tracking it says shipping from UK. so it should be here any day or so..



regarding this study, they show what happens when FDA approved more than 100 higher dosed gfs than found in cosmetics, and that on ulcers etc (open wounds..)

regarding this publication, they don't seem concerned about a balanced low dosed gfs.

Stuff worries me too much to try it myself, it's very early in the research of these things, even though they are very promising.

I applaud you guys for taking the risk though! hopefully it works out!