S-Equol Topical lotion

[jridd9]

1. Johnyboots
2. Jridd9
3. Hairismylife
4. Eire1980
5. TheChamp
6. lilpauly
7. yayay
8. cthulhu2
9. Feartheloss
10. Reign
11. Avacfc
12. PinotQ

[Jazz1]

Right lets put names copy and paste:

1. Johnyboots
2. Jridd9
3. Hairismylife
4. Eire1980
5. TheChamp

[jridd9]

I'm in also

[johnnyboots]

Guys put your names here so I can convince her to formulate this with enough orders.

Johnny boots I'm in have ordered twice from them

[Jazz1]

Guys put your names here so I can convince her to formulate this with enough orders.

[Jazz1]

Sikh prince , we will find powder s equol

So Far she has China, it would be better if it is US?

[lilpauly]

Sikh prince , we will find powder s equol

[Jazz1]

I'm in as well jazz have her but bulk powder !

You the master find a supplier in the US as bulk?

[Jazz1]

Hey guys I'm going to send her this thread link to show people are interested, il see if you can purchase this stuff in bulk.

Anyone know any place in the US that would sell this in bulk?

[Jazz1]

Jazz1, In the interest of possibly sidestepping the need to use Nature's Sunshine and filter out all of the fillers, not to mention opening up thousands of capsules to do so, can you ask Susan to see if she can get a ballpark price on bulk equol to get a sense of how many people we need and what the price might be? I had approached 2 other companies about formulating a topical and they declined saying equol was too expensive......but that was only in a quantity enough for 1 person. The price of equol seems to vary based on the type. For example, Caymen sells 25 mg of S-Equol and R-Equol for $280 but +/- Equol (I assume this has both types) at $117 for 25 mg. And Enzo sells 25 mg (presumably +/- equol) for $138. When I asked Enzo for bulk pricing, they said they didn't sell to individuals. A topical would obviously never work at any of those price points. But I have to assume that at some quantity equol is inexpensive enough to formulate in a reasonably priced topical otherwise Nature's Sunshine couldn't put 6 mg in 1 capsule. It might also be beneficial to have Susan ask about the solubility of equol. On the Caymen s-equol datasheet it says s-equol is soluble at 15mg/ml (https://www.caymanchem.com/pdfs/10010173.pdf) while the +/- equol and the r-equol has a solubility of 10mg/ml (https://www.caymanchem.com/pdfs/13184.pdf & https://www.caymanchem.com/pdfs/10010172.pdf ) I don't see from the research article whether they used S,R or +/- equol in their trials. But my understanding is that S-Equol is preferable on the theory that while they both have a similar affinity for DHT, S-Equol has a much stronger affinity for the Estrogen B receptor as well a stronger anti-inflammatory benefit. I'll see if I can dig up some research on that.

She emailed me back;

"I researched Equol powder and it is only available in a kilogram from China not through a reputable US chemical supplier"

Anyone know if it is viable in US as bulk?

[lilpauly]

I'm in as well jazz have her but bulk powder !

[Eire1980]

In..thanks Jazz..

[Hairismylife]

Please count me in.

[PinotQ]

From one of the (I believe ungranted) patents: A product for topical application can comprise at least 0.1%, and up to 10%, by weight S-equol, or R-equol, or enantiomeric mixtures.

Assuming a 200 ml bottle. Assuming 5% racemic equol which seems to bind and be cheaper, can we calculate the cost of the bottle assuming this is the major cost?

I am making a mixture now at about a .6% concentration in 3 oz of ethyl alcohol. By my calculations it takes 540mg or 1.5 bottles of Nature's Sunshine to make a batch. I arrived at this concentration b/c the alcohol would not dissolve any more equol than that. In fact, when I put 540 capsules in 3 oz of alcohol, I end up with only 2 oz after filtering. I mix this with propylene glycol at 60% alcohol, 20 PG and 20% water (the minoxidil formula). So I figure the cost at about $48 of equol ($32 per bottle) plus PG. So if we buy bulk we may be able to cut that down.

[Truthseek]

From one of the (I believe ungranted) patents: A product for topical application can comprise at least 0.1%, and up to 10%, by weight S-equol, or R-equol, or enantiomeric mixtures.

Assuming a 200 ml bottle. Assuming 5% racemic equol which seems to bind and be cheaper, can we calculate the cost of the bottle assuming this is the major cost?