Histogen show "cosmetic" results oct 2012 update

[Pate]

Originally Posted by Desmond84

Hey Pate,

As much as I would love for it to be true, unfortunately it's not

Here's a link to their current study:

http://clinicaltrials.gov/ct2/show/NCT01501617

it clearly states:

Biological: Hair Stimulating Complex (HSC) --> Phase I
Device: Dulbecco's Modified Eagle Medium, DMEM --> Phase II

This kind of explains why they only injected 8 shots rather than 200-300. It was merely a safety study!
Can't wait to see some kick ass results in Phase II though

No, it doesn't clearly state that. As I've said repeatedly, you guys are reading the site wrong.

That DMEM stuff is just the delivery medium. It is not in Phase II, Phase II is efficacy testing and you don't test a vehicle for efficacy.

The info in that table is to be read in columns, NOT ROWS. It is saying the following: the treatment of HSC is undergoing both Phase I safety and Phase II efficacy trials.

It is NOT saying that HSC is in Phase I only and DMEM is in Phase II only.

If you want final proof of this, check the primary outcome measures. One is safety, the other is terminal hair count. So efficacy is a primary outcome measure! That means it is in Phase II.

If you want even more proof, have a look at other Phase I/II trials on that site. Here's one example of several I found, search for trial NCT01121731. The primary outcomes clearly show all three drugs in that trial are in both Phase I and II.

The bad news is this doesn't mean they go straight to Phase III next. They will probably need more Phase IIs. But the good news is that HSC is definitely in Phase II trials.

[yeahyeahyeah]

Originally Posted by amibald

I'm annoyed (see amy thread) because I seem to be losing hair at 18, by the time the treatment comes out i'll be bald and I can't afford treatments!!

I would try experimental treatments from now till february when more news comes out.

Check out gutted's msm/vit c thread, some people have had success with it.

I doubt you will lose much hair over the next 6 months.

[yeahyeahyeah]

Originally Posted by Pate

No, it doesn't clearly state that. As I've said repeatedly, you guys are reading the site wrong.

That DMEM stuff is just the delivery medium. It is not in Phase II, Phase II is efficacy testing and you don't test a vehicle for efficacy.

The info in that table is to be read in columns, NOT ROWS. It is saying the following: the treatment of HSC is undergoing both Phase I safety and Phase II efficacy trials.

It is NOT saying that HSC is in Phase I only and DMEM is in Phase II only.

If you want final proof of this, check the primary outcome measures. One is safety, the other is terminal hair count. So efficacy is a primary outcome measure! That means it is in Phase II.

If you want even more proof, have a look at other Phase I/II trials on that site. Here's one example of several I found, search for trial NCT01121731. The primary outcomes clearly show all three drugs in that trial are in both Phase I and II.

The bad news is this doesn't mean they go straight to Phase III next. They will probably need more Phase IIs. But the good news is that HSC is definitely in Phase II trials.

You have lost me.

[Desmond84]

Originally Posted by Pate

No, it doesn't clearly state that. As I've said repeatedly, you guys are reading the site wrong.

That DMEM stuff is just the delivery medium. It is not in Phase II, Phase II is efficacy testing and you don't test a vehicle for efficacy.

The info in that table is to be read in columns, NOT ROWS. It is saying the following: the treatment of HSC is undergoing both Phase I safety and Phase II efficacy trials.

It is NOT saying that HSC is in Phase I only and DMEM is in Phase II only.

If you want final proof of this, check the primary outcome measures. One is safety, the other is terminal hair count. So efficacy is a primary outcome measure! That means it is in Phase II.

If you want even more proof, have a look at other Phase I/II trials on that site. Here's one example of several I found, search for trial NCT01121731. The primary outcomes clearly show all three drugs in that trial are in both Phase I and II.

The bad news is this doesn't mean they go straight to Phase III next. They will probably need more Phase IIs. But the good news is that HSC is definitely in Phase II trials.

Hmmm, Pate you might be right!

Looking at it again, DMEM was just a placebo shot they used in the placebo group! That obviously doesn't even need to be in a Phase II lol...

With regards to more Phase II trials. I tend to agree as well. Now that they did 8 shots and its all OK, they will jack up the number of shots to see what happens. Either way, early 2016 launch seems to be quite realistic.

[rdawg]

Originally Posted by Desmond84

Hmmm, Pate you might be right!

Looking at it again, DMEM was just a placebo shot they used in the placebo group! That obviously doesn't even need to be in a Phase II lol...

With regards to more Phase II trials. I tend to agree as well. Now that they did 8 shots and its all OK, they will jack up the number of shots to see what happens. Either way, early 2016 launch seems to be quite realistic.

3 years away and counting! with propecia helping me already I'll be getting my full hair back from histogen in 3 years!

[Dan26]

Originally Posted by rdawg

3 years away and counting! with propecia helping me already I'll be getting my full hair back from histogen in 3 years!

If your a NW3 you might need a quick HT to fix the front/hairline too lol, not a prob tho.

I honestly am not getting my hopes up. All I care about is the trial results and if the safety and efficacy is proven in the way I expect it to be. Whether they actually put it on the market 3, 4, 5, 6, whenever years from now, I dont care I am getting my hands on it regardless. If the science is there and proven, we are in good shape.

[Artista]

Desmond,, you laid out great logical advice for Amibald ,,good going bro!
Amibald,, please consider what he had said to you buddy

[hellouser]

Originally Posted by Desmond84

Amibald,

I'm a pharmacist and to be honest with you, I'm not so sure if taking Propecia at your age is really a good idea. You're body is still developing and your hormones are still a roller coaster!

We will know by Feb 2013 if Aderans will have a viable treatment or not...hang in till then. Enjoy your xmas holidays and based on the results they release decide how you're gonna tackle your hairloss.

Let me know, if you have any questions brother...I'm always here to help

In the meantime he could simple use Minox and RU58841 with Nizoral shampoo. Other things such as taking vitamin E and Saw Palmetto may make a small difference but help out as well. I would also encourage finding shampoos that have vitamin E and L-Arginine as well to tackle hairloss. A combo such as this has few potential side effects; Minox only sometimes cause a minor itch for me, RU typically does absolutely NOTHING for side effects. I think Saw Palmetto is the worst offender, it definitely lowers my libido which is fine being single.

Finasteride is garbage, that is stone age medication and only for the pure ignorant and lazy who are willing to risk a permanent limp dick. I cant believe that in 2012 that sh*t is still available for the public, it should be banned with other remedies taking its place (RU & CB are good candidates).

[TravisB]

Originally Posted by hellouser

In the meantime he could simple use Minox and RU58841 with Nizoral shampoo. Other things such as taking vitamin E and Saw Palmetto may make a small difference but help out as well. I would also encourage finding shampoos that have vitamin E and L-Arginine as well to tackle hairloss. A combo such as this has few potential side effects; Minox only sometimes cause a minor itch for me, RU typically does absolutely NOTHING for side effects. I think Saw Palmetto is the worst offender, it definitely lowers my libido which is fine being single.

Finasteride is garbage, that is stone age medication and only for the pure ignorant and lazy who are willing to risk a permanent limp dick. I cant believe that in 2012 that sh*t is still available for the public, it should be banned with other remedies taking its place (RU & CB are good candidates).

Risk of permament limp dick from Fin is close to none.

RU doesn't have any REAL success stories (from RU alone), has unknown side effects (potentially can be dangerous), is expensive and you have to buy it from fishy vendors on the black market.

CB is even more expensive, there also aren't any success stories from people using it (people are probably using fake CB, or they don't have proper vehicle for it's powder form). You also have to buy it from fishy vendors.

CB has potential, but we must wait until 2017 - 2018 when (an IF) it hits the market for hairloss.

[doinmyheadin]

I think Spencer needs to organize an interview with Gail Naughton to clear up or the speculation about results, phases, release date in asia, release date in America.