New Stemcell Treatment Photos... wow?

[gc83uk]

We will either have an announcement of Phase 3 this year or we won't. It's possible the effects are permanent, and it's possible the effects are only temporary. We don't know that for certain either way.

Smurf one thing is for sure, your definitely not wrong. lol

[Boldy]

"In skin undergoing androgenetic alopecia, there is the possibility
that the balance of migration is altered and incontinence of dermal sheath cells to the skin dermis leads to reduction in size of the dermal papilla,
and in turn to miniaturization of the follicle structure. If this leakage is
the result of signals from a dermal environment unique to this region of skin,
then addition of cells by recruitment might only be postponing the inevitable."
*************************

So, today, could you see any "rejuvenated vellus hairs" by Replicel, Aderans or Histogen?
Sorry, I couldn't see any ...
... because even if cell recruitment happened, any benefit would be just short-lived.

"AGA is not a stem cell problem!" - according to Prof. R. Paus and Dr. G. Cotsaelis.

there is for sure truth in your story, but that means, DR. Ghos doubeling would not work either over long term, right?

than how is it possible that it does work.....

It is, because regarding this paper from dr cotseralis:

https://www.dropbox.com/s/lni0awqestf5x73/13%20Review%20of%20hair%20follicle%20dermal%20cells.pdf

If you get a Dermal sheeth from a donor area and impant it into the host (aga are), It will recreate a dermal papilla. So its posible what DR nigams is saying, regarding the studies.

The inductive property in dermal cells was elegantly shown by Oliver when he transposed DP
beneath the upper half of amputated vibrissa hair follicles [42]. He and his colleagues then
transplanted DP into afollicular skin and induced hair growth [43]. Cultured DP and DS cells,
as well as intact DS tissue are able to reconstitute a new functioning DP in vivo [11–13,44].
Reynolds et al. introduced DS from male human scalp into the forearm skin of a female donor
and induced growth of a terminal hair follicle with a DP containing a Y-chromosome indicating
the donor origin [12]. Although we cannot be sure of the target epithelial population in this
experiment, a subsequent study also showed trans-species induction of hair follicles by human
DP [45]. If validated, these studies are significant for their demonstration of DP inductive
abilities as well as the possible immune privilege state of the hair follicle championed by Paus
and coworkers [46].

Now whats the different between the DP cells in the AGA area and outside the AGA area?:

The role of the DP in diseases of skin and hair is not known, but some have speculated that
androgenetic alopecia, which is characterized by miniaturized hair follicles and shortening of
anagen phase in a defined pattern, may be due to the effect of testosterone and
dihydrotestosterone acting on androgen receptors in the DP and causing changes in
Yang and Cotsarelis Page 7
J Dermatol Sci. Author manuscript; available in PMC 2011 January 1.
NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscripttranscription of genes such as TGF-β and IGF-1 [65–67]. Androgens may also drive the DP to
secret inhibitory autocrine factors [68]. Bahta et al. cultured DP cell from balding and nonbalding scalp and found that balding DP cells showed characteristics of senescence including
loss of proliferation capacity, change of morphology and expression of senescence-related
markers and oxidative stress markers such as p16
INK4a
/pRb, heat shock protein-27 [69]. One
recent study showed androgen regulated Wnt signaling in DP cells again suggesting their
involvement in the disease process of AGA [66].

With other words, Culturing, or transplanting the Dermal sheeth or dermal papilla cells, would lead to an immortal hairfolicle, since it can't destroy it self.


I can fully imagine that you guys are sceptic (you have your reasons for that Pictures etc that probably are not true on his site),But I rather stay Objective and focus on the facts/ studies that are proven to work in practice (Gho), and the papers regarding the dp and ds cells.



the problem with the Dermal papilla cells in the AGA area is that the are affected by DHT, which unfortunatley lead in to shutdown important pathways, like wnt, igf, shh bmps etc. Its a chain reaction of processes. apoptosis + catagen. Indeed the stemcels are perfectly intact in the AGA area, but they miss cd200+cd34+ progenitor cells. (explainable because of the chain reaction). This is good that the stemcells are still intact, since we now only have to implant or inject DP/ ds cells that are not affected by DHT), and an immortal hairfolicle could develop.

aderansresearch has created and tweaked the DP culture process in, and now seem to achieve 70% success rate, which is very promising!.

http://www.aderansresearch.com/

Regarding what I understand from nigams site, is that they culture the cells in the Dermal sheeth, and bulge, and then inject them into the scalp. If this is done right, healthy DP cells/ follicles could develop.



BTW guys, I'm Not supporting anyone here, Just focussing on the theory they seem to use.. On paper it seem to fits (so far)

The Dp/Ds culture thing got my interest lately, since I know its the only way that will give me my old nw0 back.

For your information, I'm GansterBoy on hairlosshelp.

[Boldy]

@ DR nigams, what is the success rate you have archived so far , with the DS cells culture. DR Gho, promises 20% for patients with skin burns.

[neversaynever]

Nice post gangster boy, but still, aderans nor replicel have created new follicles in their trials. Aderans are getting some re-growth, so hopefully its compoundable...


It essentially is an issue with multiplication. Its proven that a partial follicle can regenerate into a full follicle, but so far there has been no resounding success with cultured cells.

Perhaps the issue is the tissue surrounding the follicle? When Gho implants, it has some tissue with it, which might contain extra factors that allow a follicle to grow, even in AGA scalp.

Could you shed your thoughts on that? Stick around on this forum please. You've always made sense in your posts.

[neversaynever]

@ DR nigams, what is the success rate you have archived so far , with the DS cells culture. DR Gho, promises 20% for patients with skin burns.

With cultured cells nigam claims 50% sucess rate (those with very good results). And many need fue to back it up a bit, because the regrowth works better in some areas and not others.

[Boldy]

Nice post gangster boy, but still, aderans nor replicel have created new follicles in their trials. Aderans are getting some re-growth, so hopefully its compoundable...


It essentially is an issue with multiplication. Its proven that a partial follicle can regenerate into a full follicle, but so far there has been no resounding success with cultured cells.

Perhaps the issue is the tissue surrounding the follicle? When Gho implants, it has some tissue with it, which might contain extra factors that allow a follicle to grow, even in AGA scalp.

Could you shed your thoughts on that? Stick around on this forum please. You've always made sense in your posts.

Yes indeed, its actually explained in the study I posted. the part of the folicle that Gho transplants contains the dermal sheeth.


in this case in the donor area, there still will be a Dermal papilla that will recreate the damage (dermal sheeth, subaceaus gland, etc)


the upper part that will be inpanted in the host area WILL recreate a dermal papilla cell. in this case you can indeed call it doubling...(if everything goes well)

I can only recommend to read the study I posted, its very useful.

It essentially is an issue with multiplication. Its proven that a partial follicle can regenerate into a full follicle, but so far there has been no resounding success with cultured cells.

I'm curious how you get that information, do you have a source?, the trials and studies Claim that it Is possible to recreate immortal hairfolicles from Human Dermal papilla , or Dermal sheeth cells... and that the success rate currently is 70%.

the current issue is more, How can we achieve as much as possible doublings with minimal donor dp cells. and without that they loose their ability to recreate hair after couple pasages.

this topic might be usefull.

http://www.hairlosshelp.com/forums/messageview.cfm?catid=7&threadid=103913&enterthread=y

[534623]

Yes indeed, its actually explained in the study I posted. the part of the folicle that Gho transplants contains the dermal sheeth.


in this case in the donor area, there still will be a Dermal papilla that will recreate the damage (dermal sheeth, subaceaus gland, etc)

The dermal papilla? Not really ...

[Boldy]

The dermal papilla? Not really ...

Gho's procedure leaves the bottom side of the hairfolicle intact in the donor area.. if i'm not mistaken! and that part contains the dp.

[neversaynever]

Gho's procedure leaves the bottom side of the hairfolicle intact in the donor area.. if i'm not mistaken! and that part contains the dp.

youre not mistaken

[534623]

534623

how can we be so sure HM will be avail in next few years,


'with poor quality hair', i didnt understand this part,

He says Dr. Gho produces with his HST technique "poor quality hair".

didi, I don’t understand you …

http://www.drnigams.net/gallery_hair-multiplication.html

Why don’t you buy Dr. Nigam’s stem cell hair multiplication procedure?

As you can CLEARLY see, you can have 40,000 plus QUALITY HAIR just in 3,5 month!!

Buy it – and enjoy your new 40,000 plus QUALITY HAIRS!

Furthermore, in case if just 39,896 QUALITY HAIRS grow in your recipient area with Dr. Nigam’s stem cell hair multiplication procedure, you can always add the remaining 104 hairs with Dr. Umar’s 3-hair body hair grafts procedure - to thicken-up any hairless gaps.

[neversaynever]

Yes indeed, its actually explained in the study I posted. the part of the folicle that Gho transplants contains the dermal sheeth.


in this case in the donor area, there still will be a Dermal papilla that will recreate the damage (dermal sheeth, subaceaus gland, etc)


the upper part that will be inpanted in the host area WILL recreate a dermal papilla cell. in this case you can indeed call it doubling...(if everything goes well)

I can only recommend to read the study I posted, its very useful.








I'm curious how you get that information, do you have a source?, the trials and studies Claim that it Is possible to recreate immortal hairfolicles from Human Dermal papilla , or Dermal sheeth cells... and that the success rate currently is 70%.

the current issue is more, How can we achieve as much as possible doublings with minimal donor dp cells. and without that they loose their ability to recreate hair after couple pasages.

this topic might be usefull.


http://www.hairlosshelp.com/forums/m...&enterthread=y

I agree that theory backs this, but what 70% are you referring too? Im basing my info on human trials conducted by replicel, aderans. Noone has injected cultured cells into human scalp and seen amazing growth, have they?

Im not saying that its a fail at all, just that so far some more work needs to be done.

[neversaynever]

He says Dr. Gho produces with his HST technique "poor quality hair".

didi, I don’t understand you …

http://www.drnigams.net/gallery_hair-multiplication.html

Why don’t you buy Dr. Nigam’s stem cell hair multiplication procedure?

As you can CLEARLY see, you can have 40,000 plus QUALITY HAIR just in 3,5 month!!

Buy it – and enjoy your new 40,000 plus QUALITY HAIRS!

Furthermore, in case if just 39,896 QUALITY HAIRS grow in your recipient area with Dr. Nigam’s stem cell hair multiplication procedure, you can always add the remaining 104 hairs with Dr. Umar’s 3-hair body hair grafts procedure - to thicken-up any hairless gaps.

Please dont pollute the thread with your bitter sarcasm. Noone has said they will get treatment with Nigam, we merely having a discussion.

[Boldy]

I'm going to focus on the the technique + the studies that support it rather than the pictures. I

can't tell if pictures are real(maybe its just a regular ht or so,,), But what I can tell is if the procedure/ the technique is correct/ real..


Its better to stay objective
@ neversaynever the 70% is from the aderans website. and the studies that show what hapens when you inject cultured dp cells .

the current goal is to achieve the best method for culturing these cells. I still have allot of reading to get a better understanding of the current possibilities.

[534623]

Gho's procedure leaves the bottom side of the hairfolicle intact in the donor area.. if i'm not mistaken! and that part contains the dp.

Really?


Can you at least try to explain from WHERE you got your "if I'm not mistaken" story? I mean, it's normal in such forums like this forum that not just normal users make claims out of their ass - even doctors. And if everybody would just make claims out of this ass - what's the sense of such forums?

btw, your mother is a bitch - I mean, if I'm not mistaken ...

[Boldy]

Really?


Can you at least try to explain from WHERE you got your "if I'm not mistaken" story? I mean, it's normal in such forums like this forum that not just normal users make claims out of their ass - even doctors. And if everybody would just make claims out of this ass - what's the sense of such forums?

btw, your mother is a bitch - I mean, if I'm not mistaken ...

Okay, I guess, I was right about this forum...

If you don't even read the posted studies.. these claims are backedup by references.