Who is this guy? 'Hair follicles made ex vivo that can be inserted..'

[lacazette]

I repost Dr.Fabrikant offices numbers, If someone fluent could call just to ask if he works on his 3D 'lab made' hair, or if it's still just a patent? or If there's any preclinical testing collaboration, etc?

No one in US or with fluent oral english who is interested to get these infos? If so please help the community hehe

Dr. Jordan S. Fabrikant, DO
Office locations:

Skin & Cancer Associates
4308 Alton Rd Ste 510
Miami Beach, FL 33140
Phone: (305) 674-8865

2025 Indian Rocks Rd SLargo, FL 33774
(727) 586-7203 (Office)
(727) 585-7205 (Fax)

patent in page 1

[Renee]

They can't even make a folicle in the lab, I doubt they will be able to print. Our best hope is: lauster/Linder/atac, christiano/jahoda/Higgins, tsuji, terskikh, cotsraelis/xu. If you go to google patent lauster team filed a patent in dec 2014 after the congress, hopefully they have solved it now.

[Renee]

I got this from americanhairloss.org. Why isn't this available now??

Regenerative Science Being Used To Aid In Hair Regrowth
by JOHN FRANK, MD
Looking at stem cells as a cure for baldness is hardly new, but being able to bio-engineer a hair follicle from one’s own DNA would represent a significant new breakthrough – but that’s exactly what a team of researchers in genetic regenerative medicine and bio-engineering at Tokyo University have done.

Asakawa K, Toyoshima KE, Ishibashi N, Tobe H, Iwadate A, Kanayama T, Hasegawa T, Nakao K, Toki H, Noguchi S, Ogawa M, Sato A, & Tsuji T published work in Nature last May, 2012, demonstrating a technique whereby they’ve been able to bio-engineer functional hair follicles that exhibit a normal growth cycle from stem cells taken from existing hair follicles.

To demonstrate that the bio-engineered hair follicles functioned like real hair follicles, they employed a widely used hair transplant technique called follicle unit transplantation, or FUT, to transplant these bio-engineered hair follicles into the scalp of mice. Not only did the transplanted hair follicles exhibit the normal growth cycle of hair follicles, they also grew the correct type of hair and at the correct orientation as a function of the transplanted location.

In short, we can now, in principle, bio-engineer our own fully functional hair follicles based on our own DNA. When asked how soon a practical hair replacement treatment could come out of this work, the research team said they hoped clinical trials could begin within three to five years, and, if that happens, they think a practical bio-engineered based surgical hair replacement treatment procedure could exist within a decade.

[lacazette]

Is it the Tsuji that we know in this study?

Well if the research team were right, they're peraph's already in beginning trial from now, or begin soon (1/2y), then with regenerative laws in japan that could sound good before 2020.

But who's that team? let's try to find if they're still in the game.


For your first post renee, bioprinting cells are solving some previous issues researchers had regarding the hair regeneration

[Renee]

Yes it's the tsuji we know. Do u know if he used adult cells? Or was it mouse cells?

[lacazette]

It was mouse cells in that 2012 study

Tsuji make many studies since 2012 when you look the list on Ncbi; regarding bioengineered organ (teeth, hair follicles, and secretory glands)

His last one :
Reconstitution of a bioengineered salivary gland using a three-dimensional cell manipulation method.

http://www.ncbi.nlm.nih.gov/pubmed/25727330

"One concept in regenerative therapy is the replacement of a lost or damaged organ with a regenerated, fully functional organ. Three-dimensional cell manipulation techniques, designated "organ germ methods," enable the normal development of a bioengineered organ germ in several types of ectodermal organs, such as teeth, hair follicles, and secretory glands. This method is useful for both organ regeneration technology and developmental biology, including cell kinetic analysis and the elucidation of gene regulation during organogenesis. Here, we describe a protocol for salivary gland reconstitution using the organ germ method to transplant a bioengineered salivary gland germ."

We developed a novel bioengineering method, an organ germ method that can reproduce organogenesis through the epithelial-mesenchymal interaction.

[lacazette]

Study from Tsuji published today :

http://www.mdpi.com/2079-4983/6/3/634

Lacrimal tissue stem cells have been identified for use in regenerative therapeutic approaches aimed at restoring lacrimal gland functions. Fully functional organ replacement, such as for tooth and hair follicles, has also been developed via a novel three-dimensional stem cell manipulation, designated the Organ Germ Method, as a next-generation regenerative medicine. Recently, we successfully developed fully functional bioengineered lacrimal gland replacements after transplanting a bioengineered organ germ using this method.

Okay so this method seems to work for hair follicle, the problem is how long before testing in human clinical trial this organ germ method? (if it's not already the case).
at least it takes place in japan, and that's a fu..ing good point!

[Renee]

I hope his doing a phase 1 trial now. Does japan have a clinicaltrials.gov site?