Where are the phase IIb results for Bimatoprost?
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"The preferred bimatoprost concentration range is about 2-4% w/w, more preferably about 2.5-3.5% w/w. These preferred bimatoprost concentration ranges allow a surprisingly good balance to be achieved between the wanted pharmacologic effects of the composition and any unwanted side-effects. It had previously been thought that bimatoprost compositions for stimulating growth of hair should have a much lower bimatoprost concentration; this has now surprisingly been found not to be the case."
Dude, I don't have time to answer everyone's questions. I don't repost things found in other forums, I look this stuff up myself with plenty of reliable references. Go through this thread if you want all of your questions answered.
I'm done posting until we get more news about bim.Comment
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ugh, ITS IN THE PATENT. https://patents.google.com/patent/WO...atoprost&q=aga
"The preferred bimatoprost concentration range is about 2-4% w/w, more preferably about 2.5-3.5% w/w. These preferred bimatoprost concentration ranges allow a surprisingly good balance to be achieved between the wanted pharmacologic effects of the composition and any unwanted side-effects. It had previously been thought that bimatoprost compositions for stimulating growth of hair should have a much lower bimatoprost concentration; this has now surprisingly been found not to be the case."
Dude, I don't have time to answer everyone's questions. I don't repost things found in other forums, I look this stuff up myself with plenty of reliable references. Go through this thread if you want all of your questions answered.Comment
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It seems to me if you got it from the patent you could've said "from the patent", just as easily as, "from the forum". Anyways, the patent doesn't confirm your claims. The fact is you don't know what concentrations they tested, nor what the results were. All we know is that in their latest trial they tested a ten-fold increase over the previous trial that failed to meet expectations. Without knowing what the concentration of the previous trial was we can't know what the concentration of the latest trial was. They may very well have tested 1%, 3%, and 5%, and found 1% to be the optimal dose. I'm not trying to nitpick, but I don't think assumptions should be posted as facts.
Bottom line: .3% was previously tested, and that is also included in the patent, if you bothered to do some reading. Also, who gives rat crap what the actual number for the concentration is? They figured it out, and they are moving forward with bim as they plainly stated. They have said all along that if it is noticeably stronger than minox, they will move forward with it and bring it to market. All signs point to them doing just that.
You are quibbling over BS.Comment
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You are trying to nitpick.
Bottom line: .3% was previously tested, and that is also included in the patent, if you bothered to do some reading. Also, who gives rat crap what the actual number for the concentration is? They figured it out, and they are moving forward with bim as they plainly stated. They have said all along that if it is noticeably stronger than minox, they will move forward with it and bring it to market. All signs point to them doing just that.
You are quibbling over BS.Comment
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You are trying to nitpick.
Bottom line: .3% was previously tested, and that is also included in the patent, if you bothered to do some reading. Also, who gives rat crap what the actual number for the concentration is? They figured it out, and they are moving forward with bim as they plainly stated. They have said all along that if it is noticeably stronger than minox, they will move forward with it and bring it to market. All signs point to them doing just that.
You are quibbling over BS.Comment
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Again, you don't know .3% was previously tested. You have no way of knowing that. To answer your question, people who want to try it give a "rat crap" what the actual concentration is. You are telling people that you know, factually, that 3% is the optimal dosage, when in fact you are just assuming that. Someone who reads that might go out and start using an expensive compound at 3x the concentration that is necessary. All signs point to bimatoprost working better than minoxidil, but it is very important to know the optimal dosage. Let's not tell people we know what it is when we really don't.
It isn't important to know the optimal dosage because pure bimatoprost powder costs $700-$900 per GRAM. Go buy some if you're so curious, and let us know how it goes. I'll wait until a product is distributed worldwide and becomes much more affordable.Comment
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AGAIN, It shows in the patent that .3% was previously tested in patients. It gives actual evidence. Then it goes on to describe how and why it arrived at that range of 2.5%-3.5%. I'm not making anything up. You are assuming I am because you refuse to READ any material on your own.
It isn't important to know the optimal dosage because pure bimatoprost powder costs $700-$900 per GRAM. Go buy some if you're so curious, and let us know how it goes. I'll wait until a product is distributed worldwide and becomes much more affordable.
I did find this though:
Examples of particularly preferred compositions for growing hair by topical application comprise bimatoprost in free form or a pharmaceutically acceptable salt thereof, wherein the bimatoprost is contained in an amount of about 0.3% w/w to about 4% w/w
I'm about to start PGE2. If I don't have success with that I will try bimatoprost at 1%. Why should I tell you how it goes though? You're a jerk. All I did was ask you a simple question, "where did you get that information from", so that I could check it out myself. Instead of answering me you picked a fight. You don't want to help me by just telling me where you got your information from, but you want me to share the results of my experiment with you? Get out of here.Comment
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I did a little more digging and it turns out, in February 2014, Allergan invested $10.6 million into this plant in Waco for a 22,000 sq ft. expansion to produce Latisse. I think it might be fair to say, this place could be the main center in the US where bimatoprost is produced by Allergan.
and
Kris Collins, senior vice president for economic development at the Greater Waco Chamber of Commerce, said about the plant: "If it’s an eye product made by Allergan, it’s probably produced in Waco."
Now, I know this guy isn't an Allergan representative. However, he must have intimate knowledge the kind of distribution they do, what they produce, etc. etc. I'd actually trust the word of person in his position, then someone working for the company. They're more likely to not say anything at all.
It could be another drug, but I find all these coincidences are starting to paint a picture imo.Comment
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I did a little more digging and it turns out, in February 2014, Allergan invested $10.6 million into this plant in Waco for a 22,000 sq ft. expansion to produce Latisse. I think it might be fair to say, this place could be the main center in the US where bimatoprost is produced by Allergan.
and
Kris Collins, senior vice president for economic development at the Greater Waco Chamber of Commerce, said about the plant: "If it’s an eye product made by Allergan, it’s probably produced in Waco."
Now, I know this guy isn't an Allergan representative. However, he must have intimate knowledge the kind of distribution they do, what they produce, etc. etc. I'd actually trust the word of person in his position, then someone working for the company. They're more likely to not say anything at all.
It could be another drug, but I find all these coincidences are starting to paint a picture imo.Comment
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I did a little more digging and it turns out, in February 2014, Allergan invested $10.6 million into this plant in Waco for a 22,000 sq ft. expansion to produce Latisse. I think it might be fair to say, this place could be the main center in the US where bimatoprost is produced by Allergan.
and
Kris Collins, senior vice president for economic development at the Greater Waco Chamber of Commerce, said about the plant: "If it’s an eye product made by Allergan, it’s probably produced in Waco."
Now, I know this guy isn't an Allergan representative. However, he must have intimate knowledge the kind of distribution they do, what they produce, etc. etc. I'd actually trust the word of person in his position, then someone working for the company. They're more likely to not say anything at all.
It could be another drug, but I find all these coincidences are starting to paint a picture imo.Comment
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Given that you thought you could figure out hair loss by loosely piecing together a bunch of peer reviewed journals, you're not someone I'd ever listen to advice from.
Thanks, but no thanks.Comment
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Alright, well let me know when you've solved hair loss and are a billionaire. What happened to that 90-something page thread you had going with 95% of those posts belonging to you? Couldn't figure it out? Damn, you had me convinced you were so close.
Given that you thought you could figure out hair loss by loosely piecing together a bunch of peer reviewed journals, you're not someone I'd ever listen to advice from.
Thanks, but no thanks.Comment
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