Although adipose-derived stem cells (ASCs) show promise for cell therapy, there is a tremendous need for developing ASC activators. In the present study, we investigated whether or not vitamin C increases the survival, proliferation, and hair-regenerative potential of ASCs. In addition, we tried to find the molecular mechanisms underlying the vitamin C-mediated stimulation of ASCs. Sodium-dependent vitamin C transporter 2 (SVCT2) is expressed in ASCs, and mediates uptake of vitamin C into ASCs. Vitamin C increased the survival and proliferation of ASCs in a dose-dependent manner. Vitamin C increased ERK1/2 phosphorylation, and inhibition of the mitogen-activated protein kinase (MAPK) pathway attenuated the proliferation of ASCs. Microarray and quantitative polymerase chain reaction showed that vitamin C primarily upregulated expression of proliferation-related genes, including Fos, E2F2, Ier2, Mybl1, Cdc45, JunB, FosB, and Cdca5, whereas Fos knock-down using siRNA significantly decreased vitamin C-mediated ASC proliferation. In addition, vitamin C-treated ASCs accelerated the telogen-to-anagen transition in C3H/HeN mice, and conditioned medium from vitamin C-treated ASCs increased the hair length and the Ki67-positive matrix keratinocytes in hair organ culture. Vitamin C increased the mRNA expression of HGF, IGFBP6, VEGF, bFGF, and KGF, which may mediate hair growth promotion. In summary, vitamin C is transported via SVCT2, and increased ASC proliferation is mediated by the MAPK pathway. In addition, vitamin C preconditioning enhanced the hair growth promoting effect of ASCs. Because vitamin C is safe and effective, it could be used to increase the yield and regenerative potential of ASCs.
12-13-2014 09:45 AM
noisette
And I read an another research, about vitamin B12, which demonstrates a hair growth pro-moting effect of vitamin B 12 in vitro. This effect is accompanied by the modulation of intracellular signal transduction molecules of the wnt-pathway and might promote hair growth after micrograft transplantation.
Which amount do you advice for vitamine C as topical for day ?
12-21-2014 01:35 PM
lilpauly
Also vitamin e
12-21-2014 02:34 PM
Jazz1
Quote:
Originally Posted by lilpauly
Also vitamin e
Susan adds vitamin E if needed bro, I wonder if she can add vitamin C? I'm going to try on my next order to formulate glutathione, vitamin E and C seperate mixture.
I just emailed her to ask if she can formulate me the above mixture :).
12-22-2014 08:55 AM
lilpauly
Quote:
Originally Posted by Jazz1
Susan adds vitamin E if needed bro, I wonder if she can add vitamin C? I'm going to try on my next order to formulate glutathione, vitamin E and C seperate mixture.
I just emailed her to ask if she can formulate me the above mixture :).
jazz ask her about ghk !
12-22-2014 09:04 AM
inbrugge
What's a good dosage and method to include Vitamin C and E to regimen?
Is topical vitamins worth anything or will that not penetrate through the scalp? Will it be stable in a compound with Minoxidil and Tretinoin or not?
12-22-2014 04:11 PM
lilpauly
One of the best topicals for hair shed is aloe Vera gel. It's cheap
12-22-2014 08:40 PM
robodoc
Quote:
Originally Posted by noisette
And I read an another research, about vitamin B12, which demonstrates a hair growth pro-moting effect of vitamin B 12 in vitro. This effect is accompanied by the modulation of intracellular signal transduction molecules of the wnt-pathway and might promote hair growth after micrograft transplantation.
And so does CAFFEINE aid hair growth...helps doubt anyone would notice the difference. Look, not being Debbie Downer, it is just not worth getting your hopes up with Vit C or B12 .When they find the real thing, you won't read about on these blogs but don't hesitate to enjoy the commentary here....that is what you get, commentary.
07-08-2017 11:31 AM
k9gatton
Women do make antioxidants in their skin, such as Vitamin C.
There could be some truth in this, although probably not a lot, since estrogen protects and stimulates growth in hair follicles.
There was a show with real medical doctors, and there is a doctor that actually recommends pumpkin seed oil.