Spencer Kobren Interviews Dr. Jerry Cooley | ACell MatriStem Plucked Hair

[Westonci]

Ryan555 is right. I heard the same thing from the CEO and trials manager of Histogen. If all goes well they still plan to release this in Asia in 2013(hopefully the 1Q). Then the only problem would be finding a Doctor who offers it in Asia, but that shouldnt be so hard to find. Im crossing my fingers and hoping the first 2 phases go well and we should hear something by summer. I have no clue what Aderans are up to. In 2003 there release date was in 5 years, and there stil in phase 2. I read somewhere that there release is 2014 but i highly doubt that unless the phase 2 trials show great results and are able to get funds fast for phase 3 trials. If Acell shows that hairs will cycle, i wouldnt mind get a couple sessions with thata nd then getting an injection of histogen of aderans to fill in. That would be ideal.

On the forum, Miozambrotta19 says

I spoke with CEO of Histogen over email and she told me the soonest would be 2014 for overseas and 2013 would be impossible. Figure, if they start phase 1 and 2 trials in Feb of 2011 that would run for one year before results are given. Then phase 3 would start some time in late 2012 or 2013 and then would run for another year before results are given and then it would hit the market. Without funding it could get pushed back again in later trials as it got pushed back a couple times for these first trials. 2013 would be literally impossible. There is promise in these technologies but no one has any idea how they'll go. I want to be optimistic about it but there still in the beginning phases. Anything could happen. The initial phases were promising, and hopefully the next trails show even better efficiency but at this point all we can do it cross our fingers and wait. Lest not over optimistic as we know what happened with other companies and technologies.




So did you speak to her since?

[miozambrotta19]

The latest updte is that they are still planing to release something in Asia(not japan) in 2013, and for introduction in America by 2015. Again this is all on the notion that phase 1 and 2 go well and that they are able to get quick funding for the phase 3 trials. We will have to wait till summer to see the early results. If anyone wants to email them, they can go to the Histogen website and find the emails. If the these first 2 trials go well we should more then likely see fast funding. Lets just hope this happens.

[miozambrotta19]

What i dont get is how Dr cooley and Dr hitzig say 2 different things in there findings. Dr Cooley has said hes not able to multiply hairs with Acell, but Dr hitzigf says hes implanted 50 hairs on one patient and saw 150 hairs after. Dr Hitzig shows more then one patient with multiplication. Dr Hitzig also shows that he can mantain donor hairs in a strip procedure and reuse them where Dr cooley mentions he see no new hairs in a strip but one better looking and feeling scars. Why do these 2 doctors show different results or am i missing something

[HairRobinHood]

What i dont get is how Dr cooley and Dr hitzig say 2 different things in there findings. Dr Cooley has said hes not able to multiply hairs with Acell, but Dr hitzigf says hes implanted 50 hairs on one patient and saw 150 hairs after. Dr Hitzig shows more then one patient with multiplication. Dr Hitzig also shows that he can mantain donor hairs in a strip procedure and reuse them where Dr cooley mentions he see no new hairs in a strip but one better looking and feeling scars. Why do these 2 doctors show different results or am i missing something

The simple answer is: They used different methods in the usage of ACell.

Essential quotations …

Dr. Cooley

http://www.iahrs.org/news/dr-jerry-cooley-acell-matristem-slide-presentation/

Autocloning (plucking and transplanting plucked beard and/or scalp hairs):

Concerning “Autocloning”, in his presentation Dr. Cooley didn’t explicitly mention in which way (or if at all?) he applied ACell for Autocloning. He is just talking about “Hitzig’s Autocloning technique” in HIS presentation – that’s all.

ACell and Follicular Unit grafting (standard hair transplant):

Dr. Cooley: “Acell MatriStem™ powder - Mixed with saline and applied to grafts”

----------------------------

Dr. Hitzig

http://www.iahrs.org/news/acell-matristem-hair-loss-dr-gary-hitzig-displays-preliminary-results/

Dr. Hitzig: “Plucked hairs further coated with ACell.” – “Plucked hair soaking in ACell suspension.”
Dr. Hitzig: “ACell was injected in the recipient region during procedure.”
Dr. Hitzig: “Every single hair I put in there let grow 3 – 4 hairs.”
Dr. Hitzig: „ACell [powder mixed with arterial blood from the donor area = ‘suspension’] being injected directly into scalp.”

There’s the difference. That means, to multiply (plucked) hairs, you also need in addition to an ECM (e.g. ACell) suitable GROWTH FACTORS (e.g. PRP) – and NOT e.g. saline solution (leads to apoptosis!!).

[mkamph]

this concerns me. i'm going in for the autocloning with dr. cooley and thought that he and hitzig were using the same soaking technique.

anyone heard if cooley is adjusting his technique?

[Westonci]

Not true, read the following link

http://www.wipo.int/pctdb/en/wo.jsp?IA=NL2006000588&DISPLAY=DESC

[Westonci]

In the description Plucked hair + ECM is used, and they quote the following

"It is the object of this invention to overcome one or more of the above-mentioned problems, and thus to provide a method for the reproduction of human hair in which a long culturing time is not required. Extracellular matrix is produced by the (support) cells around the hair follicle. From our own research it is apparent that this Extracellular Matrix is essential for hair growth. In this invention the hairs are no longer cultured in a keratinocyte culture medium but are simply immersed for a short time in a medium which contains extracellular matrix or substitutes therefor. The hair is then put back. With this technique several hairs can grow as a result of putting back a single hair. The method according to the invention is moreover patient-friendly, because only plucked hairs can be used and no invasive method or anaesthesia is necessary, the patient does not have to come back for a second treatment after"

"According to this invention it is thus not necessary to culture the hair follicle cells; merely immersing the hair in the medium which contains extracellular matrix components or substitutes therefor is sufficient. The hair is then put back in the scalp, after which several hairs grow out of this one hair."

In the last step c) the hair of step b) is implanted in the scalp. This hair - or at least the part of the hair to which the stem cells are attached - has been in contact with a medium which contains extracellular matrix components or substitutes therefor, and probably as a consequence of this the hair stem cells which are located in that part have been 'activated1, so that they too can develop into hairs. As a consequence of this the implantation of the single hair of step b) results in the growth of one or several hairs ."

[KeepTheHair]

If every hair transplanted grows 3-4 hairs and this gets much better yield than FUE/FUT then this is definitely something truly awesome, actually.

If a 2000 graft transplant can be done, you can get ~7000 hairs growing...good hairs. I don't know anything about shock loss or whatever but I am pretty sure this could restore most hairlines.



If you get 2 procedures done or more...then you could have some really thick hair growing! But that would take a years worth of salary for any normal person and also almost 2 years of waiting for results?

Definitely awesome... Just time and money are both not so sweet with this. But I think it's a good option for anyone.

I'd like to know if it will interfere with future solutions though, like regenerative medicine etc.

Would most likely cost a fortune...but I guess thats normal for something this new.

[HairRobinHood]

apoptosis

There’s the difference. That means, to multiply (plucked) hairs, you also need in addition to an ECM (e.g. ACell) suitable GROWTH FACTORS (e.g. PRP) – and NOT e.g. saline solution (leads to apoptosis!!).

By the way ...

Krugluger W, Moser K, Moser C, Laciak K, Hugeneck J.
Enhancement of in vitro hair shaft elongation in follicles stored in buffers that prevent follicle cell apoptosis.
Dermatol Surg. 2004;30:1–5; discussion 5.

http://www.ncbi.nlm.nih.gov/pubmed/14692918

@mkamph - stop stop stop concerning your concerns:
I've no idea what Dr. Cooley currently is doing. I just mentioned what HE mentioned in his ACell presentation. That means, maybe I just understood something wrong and maybe he currently is doing similar procedures like Dr. Hitzig - no idea ...

[miozambrotta19]

Another question im confused on. Do regular transplaned hairs multiply or both plucked and reg multiply?
In the presentations and on forums Dr cooley never once mentioned that he has seen multiplication in implanted hairs, only Hitzig as noted this. Quite confusing.

[Westonci]

Another question im confused on. Do regular transplaned hairs multiply or both plucked and reg multiply?
In the presentations and on forums Dr cooley never once mentioned that he has seen multiplication in implanted hairs, only Hitzig as noted this. Quite confusing.

Actually he did, he mentioned hair sprouting out like an "offshoot" from a tree in his presentation. I think it was the in the 4th video

[Westonci]

I sent an Email too Acell.

-------------------------------------------
Question

Hello I have two questions.

1. Do you sell your acell matristem to the general public?

2. How much does it cost?


Response:

Thank you for your interest in ACell's regenerative medicine products and
technology. Our MatriStem® medical devices are available only by
prescription through a United States physician, hospital or clinic. We would
be happy to address any questions or concerns your physician may have and
provide technical information on applications and procedures for our
MatriStem products.

Please ask your doctor to explain the benefits and costs of ACell’s
MatriStem products. If your doctor is interested in speaking with a sales
representative in their area please have them email us or contact us by
phone at 1-800-826-2926 Monday-Friday 9-5 Eastern Standard Time. Thank you.

[miozambrotta19]

It would be useless to buy? How would you use it, and what would you use it for?

[Westonci]

It would be useless to buy? How would you use it, and what would you use it for?

Experiment, as well as curiosity.

For example I could use a dermaroller on my scalp, than apply the powder matristem, and who knows i might get a reversal in hairloss or something or nothing at all.

[mlao]

Better off letting the doctors do the research.