What are the causes of DiGeorge Syndrome?

[Bhavani]

What are the possible causes of DiGeorge Syndrome?

[Lasyasree]

DiGeorge Syndrome, also known as 22q11.2 deletion syndrome, is a genetic disorder that is caused by a missing piece of DNA on chromosome 22. The exact cause of this deletion is not yet fully understood, but it is believed to be due to a spontaneous genetic mutation during fetal development.

There are also some inherited genetic mutations that can cause DiGeorge Syndrome, including:

Autosomal dominant inheritance:

This means a child only needs to inherit one copy of the mutated gene from one parent to develop the disorder.

Autosomal recessive inheritance:

This means a child must inherit two copies of the mutated gene, one from each parent, to develop the disorder.

Some risk factors that may increase the likelihood of a child being born with DiGeorge Syndrome include:

Advanced maternal age:

Women who give birth at an older age may have a higher risk of having a child with DiGeorge Syndrome.

Family history:

If there is a family history of DiGeorge Syndrome, the risk of having a child with the disorder may be higher.

Exposure to certain medications or chemicals during pregnancy: Some medications or chemicals may increase the risk of genetic mutations in the developing fetus.

It is important to note that not all cases of DiGeorge Syndrome are inherited, and the disorder can also occur in individuals with no family history of the condition.
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