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Hey guys, after reading this article, I was left with some questions/concerns regarding Propecia dosages. Some of you probably know the info contained in it already, but I'll sum up the important parts.
"the percent change of DHT for placebo and .01 mg finasteride were identical and essentially zero within a reasonable statistical estimate. The change dropped by 60 % for a .05 mg dose and stayed that way for all dosages up to 5 mg. Thus a 20 times smaller dose than PROPECIA had the same effect on the DHT."
"Thus the fact that the dosage has been set by the manufacturer at a level far larger than the level measured as necessary for the main function, has not been reported publicly. Yet, the vastly lower dosages, reported in the data submitted to the FDA, would be expected to reduce the chance of side effects."
So, if such a small dosage of Fin has the same inhibiting effects on DHT, why would Merck recommend such a higher dosage??? Especially on a person who is just starting out on it. It makes no sense to me, seems like they are not only condoning, but recommending their consumers to take a USELESS risk.
Any thoughts on this would be appreciated!
Article: http://www.physics.upenn.edu/faculty.../propeciafda2/
"the percent change of DHT for placebo and .01 mg finasteride were identical and essentially zero within a reasonable statistical estimate. The change dropped by 60 % for a .05 mg dose and stayed that way for all dosages up to 5 mg. Thus a 20 times smaller dose than PROPECIA had the same effect on the DHT."
"Thus the fact that the dosage has been set by the manufacturer at a level far larger than the level measured as necessary for the main function, has not been reported publicly. Yet, the vastly lower dosages, reported in the data submitted to the FDA, would be expected to reduce the chance of side effects."
So, if such a small dosage of Fin has the same inhibiting effects on DHT, why would Merck recommend such a higher dosage??? Especially on a person who is just starting out on it. It makes no sense to me, seems like they are not only condoning, but recommending their consumers to take a USELESS risk.
Any thoughts on this would be appreciated!
Article: http://www.physics.upenn.edu/faculty.../propeciafda2/
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