Seasonal shed, or did the meds stop working?

[GroughBack]

Any update DJ?

[GroughBack]

.

[djsquared]

No update. Still off fin and still have my hair but it is still thinning but not much more than June. It may even be the same. But that’s it.

[GroughBack]

Glad to hear it! Congratulations! So what was the fin doing for you then? Sounds like nothing

[djsquared]

No. I was on fin maybe from 24-25 until 32/33. I would say it totally slowed the process down. I would suspect I would have been bald NW4-5 by 30 had I not taken it. I think I’m only a NW3v/4 now at 33 as a result. It definitely delayed the natural process.

[GroughBack]

Here' the problem with Finasteride, and why it's a losing battle for everyone.

Take a look at the Glutathione graph in response to Finasteride

http://medicaljournalofcairouniversity.net/Home/images/pdf/2009/September/30.pdf

Its a time bomb, lower Glutathione increases androgen receptor sensitivity, Explained below:

The reduced glutathione to oxidized glutathione levels appear to influence G6PDH and maybe vice versa.But this
shows indirectly(I believe) that glutathione levels ARE lower in mpb scalp.There is another study which says alopecic scalp is lower in glutathione also but doesnt state if they meant mpb specifically.

The second abstract suggests glutathione is an important
part of androgen signaling.Maybe we become more androgen
sensitive because of lower glutathione levels? But just blocking the androgen receptor may not be enough because perhaps it doesnt reverse the redox status? Sometimes when
pathways are shut down too long merely reversing the original offender doesnt restore them to back to baseline levels as a new homeostatic setpoint was determined.

We can increase glutathione levels and G6PDH(an energy enzyme) by l-carnitine and alpha lipoic acid and NAC and aged garlic(because of s-allyl cysteine).

If you think about what the cell is attempting to do,it makes sense.If a cell has a poor antioxidant defense system it better shut down energy pathways like G6PDH or it could lead to cancer.

Glutathione

Biosci Biotechnol Biochem 1999 Dec;63(12):2219-21 Related Articles, Books

Activity of glucose-6-phosphate 1-dehydrogenase in hair follicles with
male-pattern alopecia.

Adachi K, Watanabe Y, Inouye K

Research and Development Headquarters, Lion Corporation, Kanagawa, Japan.

[Medline record in process]

Activity of glucose-6-phosphate 1-dehydrogenase (G6PDH) in human hair
follicles was measured. A good relationship has been demonstrated between
the activity and the ratio of the number of the anagen hairs to that of all
the plucked hairs in the frontal-parietal region of the scalp with
male-pattern alopecia. As the ratio becomes lower so that the advancing
degree of alopecia is higher, the G6PDH activity becomes lower.

[GroughBack]

Finasteride does an extremely good job, EXTREMELY good job of robbing your body of Glutathione, the body's single most important anti oxidant. So much in fact that your sperm even shows it, and is retarded in response to ROS that the body normally defends itself against with Glutathione.

[djsquared]

A year later off fin. I’m at a NW 5. And hated looking in the mirror. In a year my mpb rapidly caught up. Today I finally decided it was time to buzz. Went to a level 1 guard. Plan on doing this for a few months then this summer probably start close shave.