Mercks developing PGD2 Blocker!

[rdawg]

wait so this is the part that confuses me. Why aren't they testing for baldness as well? or am I missing something. From what I understand they're only testing it for asthma? Cause as someone above said that means it would be taken orally, but for baldness it may need to be taken topically.

[goingquick]

wait so this is the part that confuses me. Why aren't they testing for baldness as well? or am I missing something. From what I understand they're only testing it for asthma? Cause as someone above said that means it would be taken orally, but for baldness it may need to be taken topically.

If they were testing it for baldness, too, I'd be excited as it would show that these companies think that blocking or reducing pgd2 could actually help stop/reverse hair loss. But they aren't, they're just putting out new asthma meds, so what is everyone excited about?

Not trying to be negative, I just don't see why we should care.

[Pate]

If they were testing it for baldness, too, I'd be excited as it would show that these companies think that blocking or reducing pgd2 could actually help stop/reverse hair loss. But they aren't, they're just putting out new asthma meds, so what is everyone excited about?

Not trying to be negative, I just don't see why we should care.

Because the preclinical work has already been done on these drugs, so they can be more easily adapted to hair loss than if they had to develop entirely new drugs. It will likely cut several years off the time required to get a pgd2 drug approved for hair loss.

So maybe 8 years instead of 10. ;-)

[Kirby_]

^ This. Remember too that the existing mainstream hairloss products were all developed for other medical purposes first....

[Dench57]

Bump!

Can't find anything recent about Merck's PGD2 blocker....dead in the water?

[Dench57]

Also regarding oral CRTH2 antagonists...

http://www.pulmagen.com/adc3680.html

Isn't this similar to Setipiprant? Anyway it says Phase 2 concluded in Dec '14 with data available Jan '15 but I can't find anything more.

[HARIRI]

Thank for the great post DESMOND, do you think that this new drug wont have sexual side effects like Propecia? Will the mechanism of it affect the libido and erection matters?