Histogen show "cosmetic" results oct 2012 update

[NotBelievingIt]

I'm fairly certain they didn't come out with finasteride to help hair loss. They thought it might have an affect, but it was secondary to the reason they came out with it in the first place.

The power it had was likely the unexpected part.

[yeahyeahyeah]

Hey GMONASCO,

here's a bit of history I dug out of my Pharmacology book:

"In 1974, Julianne Imperato-McGinley of Cornell Medical College in New York attended a conference on birth defects. She reported on a group of hermaphroditic children in the Caribbean who appeared sexually ambiguous at birth, and were initially raised as girls, but then grew external male genitalia and other masculine characteristic post-onset of puberty. Her research group found that these children shared a genetic mutation, causing deficiency of the 5α-reductase enzyme and male hormone dihydrotestosterone (DHT), which was found to have been the aetiology behind abnormalities in male sexual development. Upon maturation, these individuals were observed to have smaller prostates which were underdeveloped, and were also observed to lack incidence of male pattern baldness.

In 1975, copies of Imperato-McGinley's presentation were seen by P. Roy Vagelos, who was then serving as Merck's basic-research chief. He was intrigued by the notion that decreased levels of DHT led to the development of smaller prostates who lacked androgenetic alopecia. This led to development of the first Type 5 alpha-reductase inhibitor known as Finasteride".

- True story

So in other words fin will chemically castrate you.

[Pate]

The point is, the role of 5AR in both BPH and MPB was known before the first 5AR inhibitor was developed. So it wasn't altogether unexpected when fin had an effect on hair loss. However, it was developed for prostate first.

Kind of like how the new generation of antiandrogens all seem to be targeted at acne first. It's incredible but pharma companies really don't seem to be interested in MPB treatments.

[Losing_It]

Any news if Spencer will have an interview with either Gail or Ziering? I also see that the ReGenica line of skincare products cost between $150 to $175. I wonder what that means for HSC since both products contains fibroblasts.

[Desmond84]

I'm fairly certain they didn't come out with finasteride to help hair loss. They thought it might have an affect, but it was secondary to the reason they came out with it in the first place.

The power it had was likely the unexpected part.

That's exactly right!

In the 80's, the scientific community had so many diseases to deal with that AGA was really not on their priority list.

I mean if you flip through the pharmacopoeia books from 1970s and early 80s, they were hundreds of times smaller, with far less drugs listed in them. From the pharmaceutical industry's point of view, there was simply far bigger fish to fry. There were still no real treatments available for major diseases like: Diabetes, Hypertension, High cholesterol, Angina, Heart attacks, Stroke, and Cancer!

Luckily today, a lot of these major medical burdens have been resolved or at least kept under control which has shifted the pharma companies attention towards untapped markets that were not explored in the past like hair loss.

To make things even better, we are lucky enough to live in an era where the "Human genome project" is completed, the medical world is being flooded with state of the art "biological" therapies, and the regenerative medicine is booming!

Now, these TWO important factors happening coincidentally at the same time has created a perfect environment for developing a permanent solution for hair loss. One that would involve a biological approach

These are exciting times indeed. Just flipping through some TED talks would simply make you gawk at the things in the pipeline and are coming out in just a few years.

Being involved in trials myself and a great admirer of science in general, I can promise you all this much. Things are looking incredibly bright for every human being walking this earth right now. So there's no reason to feel down or upset about a receded hairline or a thinning crown. The solutions are closer than you think and will be here b4 you know it. Just hang in there and enjoy everyday like its your last. Otherwise whats the point of living? right?

Peace out to all my balding brothers and sisters. Love you all

- Des

[2020]

nothing's changed it's just the business-types got better at creating hype and making money doing as little as possible.
Gene therapy is not coming in your lifetime nor would you really need it. The actual cure for MPB is to remove all androgen receptors from your scalp and the exact same thing has already been done in some experiments with people with prostate issues. They just don't get it...

[yeahyeahyeah]

Any news if Spencer will have an interview with either Gail or Ziering? I also see that the ReGenica line of skincare products cost between $150 to $175. I wonder what that means for HSC since both products contains fibroblasts.

I remember in their first PDF, when they were looking for investors, histogen projected a price less than 5000, think it was 1000

[Dan26]

nothing's changed it's just the business-types got better at creating hype and making money doing as little as possible.
Gene therapy is not coming in your lifetime nor would you really need it. The actual cure for MPB is to remove all androgen receptors from your scalp and the exact same thing has already been done in some experiments with people with prostate issues. They just don't get it...

Do you have any links/studies about the experiments with people with prostate issues?

[yeahyeahyeah]

nothing's changed it's just the business-types got better at creating hype and making money doing as little as possible.
Gene therapy is not coming in your lifetime nor would you really need it. The actual cure for MPB is to remove all androgen receptors from your scalp and the exact same thing has already been done in some experiments with people with prostate issues. They just don't get it...

Im sure the scientists at histogen and all those other bio companies will be pissed if they read that considering they are in the game to innovate.

Not only have you downplayed their efforts (which is ironic considering you are nothing more than an arm chair critic), you are doubting their intellect with your arrogant statements. The lead scientist at Histogen is a Cambridge graduate.

I work for a start up, IT related. Every start up I know has one thing in common - the goal in the end is to release a product, not to **** around like you make it sound like. Histogen have already released their regenica line, so there is no doubt they will relase this onto the market. They are currently trying to build a portfolio of products.

Heck - if this was Histogens intent, when they were being sued by Skinmedica, why did all the scientists working on it stay on? They could have left and work elseware if they were true mercenaries. I feel they believe in what the are doing.

[Dan26]

Im sure the scientists at histogen and all those other bio companies will be pissed if they read that considering they are in the game to innovate.

Not only have you downplayed their efforts (which is ironic considering you are nothing more than an arm chair critic), you are doubting their intellect with your arrogant statements. The lead scientist at Histogen is a Cambridge graduate.

I work for a start up, IT related. Every start up I know has one thing in common - the goal in the end is to release a product, not to **** around like you make it sound like.

Heck - if this was Histogens intent, when they were being sued by Skinmedica, why did all the scientists working on it stay on? They could have left and work elseware if they were true mercenaries. I feel they believe in what the are doing.

They have known for a long time that they have a solution that works. Believe it or not there are people that have used similar formulations in the past with great success. It isn't cheap to source these ingredients on a small scale though. We should be grateful that Histogen is determining the safety and effective dose range. I don't think it will be THAT expensive for them to produce on a mass scale, but I expect it to be overpriced when it finally hits the market.

[yeahyeahyeah]

They have known for a long time that they have a solution that works.

Exactly. Histogen already have a track record of getting products onto the market. One has to look at their regenica skincare range being released to see that.

2020 is a damn fool.

[yeahyeahyeah]

We should be grateful that Histogen is determining the safety and effective dose range. I don't think it will be THAT expensive for them to produce on a mass scale, but I expect it to be overpriced when it finally hits the market.

WE should be grateful that so many companies are working on this. Full Stop.

If we were alive 20 years ago, there would be nothing of great significance going on except for fin.

This is why Iron_man and 2020 shock me. I guess they are both bitter high norwoods. Who are pissed that this treatment wont work on them.

[ccmethinning]

I work for a start up, IT related. Every start up I know has one thing in common - the goal in the end is to release a product, not to **** around like you make it sound like.

Wrong. Example: RepliCel. Their only goal is to dick around investors and to sell their patent.

[534623]

Histogen already have a track record of getting products onto the market. One has to look at their regenica skincare range being released to see that.

According to this, Dr. Gail Naughton must now look like a 20-year-old model (again) – right? Does she?

If not, exactly the same (unchanged to “questionable effects”) WILL happen for baldies after release of Histogen’s hair stimulating complex (HSC).

Please bookmark THIS post ...for later reference, you know...

[yeahyeahyeah]

Wrong. Example: RepliCel. Their only goal is to dick around investors and to sell their patent.

Yeah, well on the flip side. Replicel stock/investment is only as good as their product.

After a while they will get hustled. They already have been.