Cetirizine

[thechamp]

I'm going to get on fin for a month gain weight get my hair back then add cet and get off fin wonder if cet will keep fin hairs?

[rdawg]

I wish we could know which is the better pathway - inhibit production of prostaglandins with Cet, or inhibit the specific receptor with Rambo.

from what ive read on HLH rambo isnt doing much but it is early.

Only indo/cromo and CET have had solid results at least so far.

The theory i think has merit to it for sure, but I dont think its PGD2 alone that will help us, we're missing the other piece of the puzzle(PGE2 promotion? Wounding?) something else.

[KO1]

Cet according to the poster above me, increases PGE2 so that's good.


Wounding is a totally separate pathway, but PGD2 seems to hurt wounding induced neogenesis.

[KO1]

http://www.ncbi.nlm.nih.gov/pubmed/2469708



and http://www.ncbi.nlm.nih.gov/pubmed/7741033

Boldy's response:

PGD2 is produced by H-pgds and non ezymic L-pgds. In aga its produced by elaveted L-pgds (cots).

Histamine antagonists, probably act on mast cells, and reduce H-pgds(hematopoietic prostaglandin D synthase).

PGD2 in hair follicles is not caused by HPGDS - hematopoietic prostaglandin D synthase BUT, by LPGDS lipocalin pgds.

Source? read the 22 march study of DR. cots. LPGds levels are highly elevated....

http://www.ncbi.nlm.nih.gov/pm...bin/nihms366359f2.jpg

Increased PGD2 pathway activity in balding scalp of men with AGA. (A) Expression of lipocalin-type PTGDS mRNA in bald versus haired scalp, as tested by qPCR. Data are means &#177; SEM (n = 4). (B and C) The amount of PTGDS protein in paired bald (B) and haired (H) scalps (n = 4), as shown by Western blotting with Ponceau stain used for verification of equal loading (B) and its quantitation as normalized to haired scalp (C). Data are means &#177; SEM. (D) PGD2 production in bald scalp, as tested by ELISA. Data are means &#177; SEM (n = 3). (E and F) Fold change in PGD2 (n = 17), 15-dPGJ2) (n = 7), and PGE2 (n = 17) expression in bald scalp compared to haired scalp (E). Total prostaglandin content is quantified in (F). Data are means &#177; SEM. *P < 0.05; **P < 0.01. In (F), P value compares haired versus bald samples for each prostaglandin.

[thechamp]

I hope cet does nearly half as much as fin

[TO YOUNG TO RETIRE]

guys is it possible for a topical to be made like all in one, like to have cetirizine (pgd2) +an antiandrogen like cb + a growth stim like nanoxidil... it would be miracle product, compide that with a niz shampoo and some anti dht styling gel product with aloe and there you go....

can sth like that be made with the current tech?

[thechamp]

guys is it possible for a topical to be made like all in one, like to have cetirizine (pgd2) +an antiandrogen like cb + a growth stim like nanoxidil... it would be miracle product, compide that with a niz shampoo and some anti dht styling gel product with aloe and there you go....

can sth like that be made with the current tech?

Does nanoxidil work?

[TO YOUNG TO RETIRE]

i havent seen any clinical data but considering it is the same but smaller molecule as minox i would assume yes.

Does nanoxidil work?

[thechamp]

If nanoxidil does work why does every one still use minoxdil then

[TO YOUNG TO RETIRE]

i really dont know if it works for sure but i also dont know why the masses stick to ancient drugs too

[Pentarou]

i really dont know if it works for sure but i also dont know why the masses stick to ancient drugs too

Because they're cheaper, genericised and have much more evidence behind them. I know what you mean though, the Big 3 are practically palaeolithic.

[thechamp]

liposome technology with cet would be awsome

[rdawg]

Gonna get on this stuff early next week guys, I'll keep track with pictures and such!

been on Fin for over a year time to start something new(havent had side effects, but I only maintained, which still leaves me as a NW3 diffused thinner!)

[rbrown]

So guys what are the latest updates on cetrizine?Any success stories from this forum?The member Pate stopped updating in december 2012. He wasn't having any regrowth at the time.

[KO1]

I'm not sure we should see success on it. As Boldy posted, does not inhibit the correct mast cell population, however, it does increase PGE2 apparently, which could be the cause of some results.

But we should then get PGE2.