Cetirizine

[rdawg]

Okay, so this is the official launch of Pate's Phase II cetirizine trial. Pate skipped pre-clinical and Phase I because damn the torpedos, that's just how Pate rolls!

But seriously - I am extremely confident from reading up on cetirizine's safety profile that at the sort of doses we are using here, to use it topically for a few months is well and truly safe. I will report any systemic effects or sides I encounter.

The formulation is:

62 x 10mg Zyrtec tablets crushed up in 60mL of demineralised water (the 2 extras are to account for losses)

I will apply 0.5mL once daily to the right temple only, which is comletely bald in a NW3 pattern (the rest of my hair is thinning heavily in a NW6 pattern). The left temple will be control (unless I start sprouting new terminal hairs in which case I'll even it out so I don't look funny) This is 5mg total cet per day - even if the absorption systemically is 100%, it's still equivalent to only half a Zyrtec per day.

I will update here every month. If I see growth I will take photographs. If not I won't bother. If I see no growth whatsoever by 3 months, I will consider upping the dose and/or frequency and/or adding minox.

This is a weaker dose than casperz is using and there is no minox, so if it doesn't work, don't write off cet or PGD2 inhibitors entirely. I just want to start with a low dose.

I am also taking 1mg fin per day and using 2% Nizoral 2-3 times per week.

So here goes. Wish me luck!

Good luck pate, keep consistent with pictures by the way please, try to maintain same lighting and angle.

Also how long have you been on fin for? if you're only a couple months in the fin may affect the results.

[CVAZBAR]

Some dude at Hairsite is also on a PGD2 blocker and claims that his hair also stopped shedding. He says no other medication ever did until PGD2. Does anyone know if he is using CET?? You Guys should check it out!

[Pate]

Good luck pate, keep consistent with pictures by the way please, try to maintain same lighting and angle.

Also how long have you been on fin for? if you're only a couple months in the fin may affect the results.

I'll do my best with the photos but I don't have the equipment that that German guy has so keep that in mind. I shave my head to a #1 so there are no worries about lighting or angle or combover effects, and if this stuff regrows terminal hair you will be able to see it on my photos. If the photos aren't good enough to clearly show it, I will take that to mean the regrowth is cosmetically insignificant and the trial has been a failure!

I've been on fin for over four years now. It grew a total of 3 terminal hairs in my entire temples, I can see them about 1cm in from my hairline. I don't anticipate it will have any effect, unless there is some synergistic effect where the PGD2 inhibition is more effective because less DHT is in the follicle - which is possible I guess.

Just upgraded to 2% keto a month ago but before that I was using 1% so I don't think that will have much effect either.

Anyway, thanks for the support guys. Now we play the waiting game.....

[Pate]

one favor, please update more frequently if you experience significant changes early, i.e. shedding absolutely stops, tons of vellus hairs start getting longer, or lots of hairs start turning terminal. you don't have to post pics, just a line or two would be great to let us know you're seeing comparable results to casperz and the others early on. i'd really appreciate that, and i'm sure others would too!

Will do. Keep in mind I'm only applying it to the bald spot and maybe 1cm along the hairline at this stage so I don't expect a massive shed, but I will report anything I observe that I think is noteworthy.

It's been about 9 hours since my first application and I haven't noticed anything yet in terms of sides. Unsurprisingly since I only applied 10mg, but there was no reaction on the skin and no systemic effects that I can tell, I didn't get drowsy or anything. I actually applied this first dose to my entire scalp to test for sides, now I'll go back to just the temple.

Correct. If my calculations are correct I'll be going from a 1% solution to 2%. Someone please correct me if I'm wrong.

I used .6g / 60ml = .01% and 1.2g / 60ml = .02%?

Correct, on a weight/weight basis. 600mg in 60mL is 1%, 1200mg will be 2%.

I am using 1% too but will only be applying 0.5mL once per day because I'm only treating one temple at this stage.

[Gjm127]

Will do. Keep in mind I'm only applying it to the bald spot and maybe 1cm along the hairline at this stage so I don't expect a massive shed, but I will report anything I observe that I think is noteworthy.

It's been about 9 hours since my first application and I haven't noticed anything yet in terms of sides. Unsurprisingly since I only applied 10mg, but there was no reaction on the skin and no systemic effects that I can tell, I didn't get drowsy or anything. I actually applied this first dose to my entire scalp to test for sides, now I'll go back to just the temple.



Correct, on a weight/weight basis. 600mg in 60mL is 1%, 1200mg will be 2%.

I am using 1% too but will only be applying 0.5mL once per day because I'm only treating one temple at this stage.

Excellent stuff Pate, I'm probably going to jump on your bandwagon some day soon with the temple application only.

[clandestine]

casperz, thank you for dropping by btt and giving us an update. Very much appreciated.

[hellouser]

There must be a more powerfull over the counter blocker than cet which would work even better ?

If there is, I wanna know what to buy.

[The Alchemist]

Will do. Keep in mind I'm only applying it to the bald spot and maybe 1cm along the hairline at this stage so I don't expect a massive shed, but I will report anything I observe that I think is noteworthy.

It's been about 9 hours since my first application and I haven't noticed anything yet in terms of sides. Unsurprisingly since I only applied 10mg, but there was no reaction on the skin and no systemic effects that I can tell, I didn't get drowsy or anything. I actually applied this first dose to my entire scalp to test for sides, now I'll go back to just the temple.

Good luck, dude. I'm into my 3rd week on the stuff and haven't detected any side effects what so ever; and i'm prone to them. Well, as long as you don't count shedding, which i experienced but am still not a 100% sure it was due to the meds. Also haven't noticed any growth at all. my recessed corners are still bare as a babies ass, not a vellus in sight. Would love to see something soon, however small, just to let me know if it truly is working or i'm wasting time.

[Pate]

Around the one month stage is where I'd expect to start seeing the first action so hopefully you'll see something soon.

Are your temples really completely hairless? My temples are still covered in baby vellus hairs that only grow about 1mm long, then near the hairline they get a bit longer but are still totally unpigmented. So my temples LOOK slick bald but in reality they do have hairs.

[thechamp]

clarayntine loratadine

clarayntine loratadine reduces pgd2 levels more who's gonna have the balls to try it ?

[The Alchemist]

Around the one month stage is where I'd expect to start seeing the first action so hopefully you'll see something soon.

Are your temples really completely hairless? My temples are still covered in baby vellus hairs that only grow about 1mm long, then near the hairline they get a bit longer but are still totally unpigmented. So my temples LOOK slick bald but in reality they do have hairs.

My temples are hairless, so if this grows any hair, i'll be able to detect it rather easily. Lets hope that happens

[Pate]

My temples are hairless, so if this grows any hair, i'll be able to detect it rather easily. Lets hope that happens

I guess that probably means your hairs are ending their anagen phase before they've even broken the skin, whereas mine are JUST breaking the skin before they cycle.

In that case I would probably expect yours to take a bit longer because they may have to cycle more than once before they break the skin... you might have to wait a while more.

Alternatively it might just not work for either of us... I went back over the German forums and several guys there have posted photos that it'd be hard to argue are showing any growth whatsoever. At least like you said when we're applying it to the temples it'll be easier to see.

[Dazza]

clarayntine loratadine reduces pgd2 levels more who's gonna have the balls to try it ?

why dont you try it out...

is there a link to the german forums?

[thechamp]

I will try it out

I'm Norwood one not shedding trying topical fin with spectral dnc snd using nizoral I shed maybe 2 hairs a day so ill wait too see results from others!

[JDW]

Some dude at Hairsite is also on a PGD2 blocker and claims that his hair also stopped shedding. He says no other medication ever did until PGD2. Does anyone know if he is using CET?? You Guys should check it out!

Can you be more specific? what is he on exactly?

Also, well done to those trying this out, look forrward to hearing the updates