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Really noticeable results, congrats! Apologies if you've already stated this somewhere in the thread, but what brand MSM are you using? I have some Holland and Barrett MSM which is 750mg, which I'm introducing my body to slowly. Unsure whether to splash out on the TXR2 too. I'm a diffuse thinner in the early stages, but with an aggressive itch.
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This from a knowledgeable health guy on immortal hair forums about 4 g vit c. He knows his stuff.
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Its kind of a controversial subject. If you ask Linus Pauling, he'd probably say it was totally safe. I believe that at one point he was taking 20-30 g daily, and lived to the ripe old age of 93.
We can probably assume that there is an upper limit for health reasons, as vitamin C in too high of amounts actually contributes to oxidation. So the negative effects may not be acute for some, but from a practical standpoint, going above a certain amount might just be counterproductive to what you are trying to achieve in the first place, which is an antioxidant effect. The adverse effects of too high of intake that you would notice are almost strictly gastrointestinal (if one experiences them at all). You'd get stomach cramps and diarrhea. That's probably one way of telling if your dose is too high.
A study out of Cornell from some years ago tested the body's capacity to absorb vitamin C. They found that there is a relative limit and it depends on how high the dose is, i.e. there are diminishing returns. Once you hit a certain gram/day dose, you actually start absorbing less of it so its counterproductive.
A 5g/day dose was absorbed at a rate of 35%, with the rest being excreted in urine. At 10g/day in two divided doses, total absorption dropped to around 25%. Some people will absorb more, some less. I'd imagine Linus, even if he was at the high end of the distribution, was probably only absorbing 3-5 grams of what he was taking each day.
According to the author, the limit of absorptive capacity of the human intestine for vitamin C is reached at about 3 g per day. 4 grams daily is probably safe. But for me, its an issue of usefulness. 500mg-1000mg doses taken with meals 3 meals a day should be just fine.
I believe A < R was doing around 4 grams daily, and said good things about this.Comment
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Did anyone have a big increase in sebum production after starting this? I've been on around 5-6g MSM and 2-3 VitC for around two weeks, and my hair is very oily.Comment
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It's 7 month mark for me.
Skin, nails still look great, itch is still low, shedding is as usual. 30-50 hairs when washing. (I wash hair every 4-6 days). NO OIL AT ALL - this is a huge success for me because I had hell of an oily scalp, literary I could scrape a few grams of that shit from my had.
But on the downside - no regrowth. It's really hard to tell because I'd need to cut my hair short and compare to early 2012 pics, but I'm pretty sure there is non, at least not noticeable.
I'm pretty sad because I've seen mr.blondes results which are SUPERB! I hoped to see something like that myself.
Oh, well, I'm continuing with MSM for sure, but I'm feeling I need to add something stronger like RU or BNP to really make it regrow, I'll wait for more results from you guys and then decide.
In the long term I'm probably going for HM @ Dr. Nigam (still waiting for OBIs results and his improved technique), I believe I could have good results because I'm diffuse, and HM gave some very good results on diffuse thinners.
I'll stop jerking because that just builds up dht and my hair is far more important than porn so...
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So your are not on TRX2 then?It's 7 month mark for me.
Skin, nails still look great, itch is still low, shedding is as usual. 30-50 hairs when washing. (I wash hair every 4-6 days). NO OIL AT ALL - this is a huge success for me because I had hell of an oily scalp, literary I could scrape a few grams of that shit from my had.
But on the downside - no regrowth. It's really hard to tell because I'd need to cut my hair short and compare to early 2012 pics, but I'm pretty sure there is non, at least not noticeable.
I'm pretty sad because I've seen mr.blondes results which are SUPERB! I hoped to see something like that myself.
Oh, well, I'm continuing with MSM for sure, but I'm feeling I need to add something stronger like RU or BNP to really make it regrow, I'll wait for more results from you guys and then decide.
In the long term I'm probably going for HM @ Dr. Nigam (still waiting for OBIs results and his improved technique), I believe I could have good results because I'm diffuse, and HM gave some very good results on diffuse thinners.
I'll stop jerking because that just builds up dht and my hair is far more important than porn so...
I have taken a setback recently since my last posting. I was unable to purchase TRX2 and went a month without. In that time my hair became very thin and I shed at the hairline a lot. I believe my crown area is still stable but I am now convinced TRX2 does something in terms of thickening and growing hairs.
I just got my supply today and hope to strenghten my hair again. I will keep you posted.Comment
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Nope, never thought much of it. Do you think I should go for it?
I have the same kind of hairloss as you do - and you had what I believe is amazing regrowth with this combo.
hmmm... I definitely need to add something - im thinking RU or BNP, if you believe trx gave you good results I can try it for at least 5-6 months...Comment
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Well the reason I went with this combo was that it was all natural. I had read many people laugh at TRX2 but one or two say it maintained things for them. I jumped on this with the belief TRX2 might help maintain and VITC/MSM would help regrowth. I now believe TRX2 is the regrowth factor.
Regrowth is hard to notice and I believe many people would have been on TRX2 and had some results but not notice them as its such a sow process and you continue to shed some hairs. Its only when I compared my pictures that I noticed something. I went through other private pictures of my face and noticed things thicker at the front. Be diligent people, take pictures, its like weight loss, its hard to notice unless you have a scales to tell you what works and what doesn't.
I should say this though, I would always lose at the hairline/ temples but at a slower pace since jumping on this and its the hardest place to maintain. I had a bad batch of MSM from ebay and I went a month without TRX2 and my hair thinned dramatically, its been a major setback. I will not let this happen again. I will post more pictures in a few months after being on TRX2 and compare them with now to see have things improved again.
I'll offer this advise for those thinking of using TRX2. Its not cheap, about €70 if ordering individual bottles and like Fin or Minox your are going to lose gains if you drop of it. My second piece of advise is to order in bulk, three bottles per order. Twice TRX2 have been out of stock when ordering and I ran out. They can take a few days from placing the order to shipping so always reorder when you are half way through your last bottle.
My plan is to hang on to as much as I can unitl Histogen hits and have a HT to get a great hairline. I am also looking at BNP with interest and will jump on this if positive results come in soon.Comment
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My advise would be to hang on a little longer and see do I recover from this set back and we will have confirmation of TRX2 and this combo helping me a second time. Also BNP might produce something, we should know this an 6 weeks or so.
I things are desperate and you need to pull the trigger on something only you can decide which way to go and as we all now people react differently to different treatments.
I am very wary of recommending a treatment to somebody for these very reasons as hair means so much to people and I would not want to be responsible for any bad results
All I can do is point you towards TRX2's trial results
Make of what you will. The ingedients of TRX2 are interesting if researched individually and I am considering buying these individually as you will get more for less cost.9 months (active treatment group)
Hair count (Mean number of hair in an area of 2×2 cm): +35.1%
Hair Thickness (Mean weight of hair – bundle of 30 strands): +22.5%
Terminal hair change (% change from vellus to non-vellus): +23.2%
Self-evaluation of satisfaction (score between 0-10 cm with 10 being the most satisfied): 7.8 ± 2.0 cm
18 months (active treatment group)
Hair count (Mean number of hair in an area 2×2 cm): +49.2%
Hair Thickness (Mean Weight of hair – bundle of 30 strands): +38.7%
Terminal hair change (% change from vellus to non-vellus): +36.4%
Self-evaluation of satisfaction(score between 0-10 cm with 10 being the most satisfied): 8.6 ± 1.6 cm
This is taken from another forum
The most interesting ingredient here is L-Carnitine L-Tartrate (carnipure). It is thought to upregulate or increase the density of androgen receptors in muscle tissue. Would it have the same effect at the scalp? At first thought this seems bad given what we think we know about MPB...however;
- maybe an increase in androgen receptors in muscle pulls more DHT out of your body at the muscle cells, slowing the rate at which androgens bind to sites at the follicle.
- maybe more receptors at the scalp increases the amount of time it takes for androgens to fully saturate receptors at the follicle.
- maybe both
- maybe neitherComment
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hairloss-research.org did their own study of TRX2 and concluded the following and suggest their own treatment
Carnitine is an amino acid that occurs naturally in the human body and is essential for turning fat into energy. Local active energy metabolism is an essential prerequisite for healthy, sustained hair growth.
Research has conclusively shown that in balding areas of the scalp in both men and women, the membrane potential of the hair follicle is significantly diminished, in response to an androgenetically mediated reduction in potassium channel function within the hair follicle.
Mitochondrial membrane potential improves to some degree with supplemental Carnitine and even more so with Acetyl-L-Carnitine, which actually strengthens the functioning of mitochondria itself.
Dr. Thomas Whitfield, of Oxford University and Oxford BioLabs found that “L-carnitine stimulates energy production and cardiolipin synthesis within the cell membranes of hair follicles. It transports nutrients to dysfunctional potassium channels and helps to restore functionality.”
In a recent experiment with balding human hair at the University of Lubeck in Germany, Carnitine was shown to promote hair growth, stimulate hair shaft elongation and reduce hair cell death.
The authors of this study concluded, "Our findings suggest that Carnitine stimulates human scalp hair growth by up regulation of proliferation and down regulation of apoptosis in follicular keratinocytes in vitro. They further encourage one to explore topical and nutraceutical administration of l-carnitine as a well-tolerated, relatively safe adjuvant treatment in the management of androgenetic alopecia and other forms of hair loss."
Carnitine has been significantly upgraded in the last 2 years, resulting in forms that are more bio-available, even conferring documented cognitive benefits.
Acetyl-L-carnitine is the acetylated ester of the amino acid L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane compound that helps maintain mitochondrial bioenergetics increasing Potassium Channel function and lowering the increased localized and systemic oxidative stress associated with aging. Although Acetyl-L-carnitine and L-carnitine are absorbed into the bloodstream efficiently and are effective at carrying long-chain fatty acids across the membrane into the mitochondria where they are burned for energy production, Acetyl-L-carnitine also guards against oxidative damage. Acetyl-L-carnitine exerts protective effects against such neurotoxicity and oxidative stress.
Acetyl-L-carnitine arginate (ArginoCarn®) is a patented form of carnitine. Cell studies suggest that unlike Carnitine alone, it promotes the growth of neurites that facilitate communication among nerve cells in the brain.
GlycoCarn® is another patented form of carnitine. This form offers such benefits as enhanced fatty acid metabolism, membrane potential, antioxidant activity and like minoxidil, increased blood flow and significantly increased nitric oxide production.
Optimized Carnitine with GlycoCarn® combines these three recently developed forms of carnitine in one single formula to maximize the membrane potential of the hair follicle, which in cases of hereditary Androgenetic Alopecia, diminish over time. The effects on hair follicle membrane potential of these advanced forms of Carnitine well exceed that of L- Carnitine, which is used in a patent pending formula in combination with Branched Chain Amino Acids, Niacin and Potassium Chloride to restore Potassium ion channel function to hair genetically affected by androgens.
This patent pending oral minoxidil mimetic, (TRX2) developed by Dr. Whitfield, has had encouraging results in phase 2 trials (18 month point), released in October of 2011.
There were 59 participants, men and women affected by Androgenetic Alopecia.
Hair counts increased an average of 49.2%
Hair thickness increased 38.7%
Terminal hair change, (vellus to terminal) 36.4%
In all, 87% have reported cessation of hair loss.
Dr. Whitfield’s TRX2 formula is comprised of Carnitine, Branched Chain Amino Acids, Niacin, and potassium chloride. This formula can also be readily replicated at a higher potency by simply obtaining these ingredients separately, and even enhanced by using more advanced forms of Carnitine.
Our recommendation for Potassium Ion Channel restoration for hair growth consist of :
Optimized Carnitine with GlycoCarn: 1-2 capsules a day
Branched Chain Amino Acids-: 2-4 capsules a day
Niacin: 1 capsule a day
Potassium Citrate: 1 capsule a day
Thanks to the painstaking research conducted by Dr. Whitfield, the systemic stimulation of Potassium Ion Channel Function (minoxidil mimetic) can now be used as a sole intervention, or integrated into an existing hair loss treatment regime of natural DHT inhibitors and anti-inflammation agents. Although it is likely through the mechanisms identified by Dr. Whitfield, that both Carnitine and Branched Chain Amino Acids offer some benefit to hair loss on their own, it is the combination of the above mentioned compounds that would appear offer optimal benefit for both health and sustained hair growth.Comment
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If you look at the TRX2 website they claim the product is for norwood 1-4 range and is not going to do anything for slicks. So it would suggest it works on thinning hair and saves some weak hair folicles. They claim it improves activation of the potassium channels & allows more nutrients to reach the follicles to allow hair to grow.
Their claims are not to outrages and their after pictures are not too far fetched which I like too, this is something similar to my experiece, although the before picture seems to have a brighter light on the scalp then the after picture or is that just my take on it?
More pics found here http://www.trx2.com/store/hair-loss-treatment/
Make of it what you will but document your progress at all times no matter what treatment you use not for us but for your own benefit, its hard to see progress day by day by just glancing in the mirror.Comment
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Many bodybuilders have been taking carnitine for training years, don't you think someone would have reported hair growth by then ?Comment
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Its not the carnitine alone, after all carnitine is a naturally produced amino acid in the body that turns fat into energy so there wold be no balding if its was the cure. Its carnitines relationship with L-carnitine which stimulates energy and more so Acetyl-L-carnitin which increases Potassium Channel function (which is exactly what Minox also does) and lowering the increased localized and systemic oxidative stress associated with aging.
Bodybuilders efforts may be hampered by the high levels of testosterone they are producing and nothing supplementing the carnitine intake.
Its the combo that is important, as the report says the mechanisms identified by Dr. Whitfield, that both Carnitine and Branched Chain Amino Acids offer some benefit to hair loss on their own, it is the combination of the above mentioned compounds that would appear offer optimal benefit for both health and sustained hair growth.
I believe TRX2 causes some regrowth, not life changing regrowth but if it can stop loss and regrow hair side effect free its a better product than Minox or Fin as an option to maintain until a real big hitter comes to market.Comment
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