Vitamin-Boosted Stem Cells Show Promise in Curing Baldness

[2020]

Vaccinations are innocuous (or ideally they are innocuous) injections that encourage the immune system to create antibodies targeted at harmful substances. This allows the body to prepare for the introduction of that harmful substance without being put in harm's way. The process is based around what's called "adaptive immunity"; unfortunately for our hair (but fortunately for everything else), it is system wide. You wouldn't want a vaccination that caused your immune system to identify androgen receptors as pathogens. Unless, of course, you were tired of being alive.

yes yes I know what vaccinations are... that's obviously not what I meant.

androgen receptors are COMPLETELY unnecessary and they only cause problems so why not just ****ing remove them? Instead of spending another decade researching stupid shit like "oh X component may have some effect bla bla" just solve this problem at the root.

This is insane. There is no need to "clone" hair. Replicel and Aderans are wasting time and money. They need to come up with a way to "disable" AR but of course medicine never takes a direct approach when solving problems instead we'll be waiting another decade while they research the right "cell niches" or some crap... yeah whatever

[Davey Jones]

androgen receptors are COMPLETELY unnecessary and they only cause problems so why not just ****ing remove them?

You probably don't actually mean that either, but I just thought the idea of physically removing an androgen receptor looked silly. Picturing a surgeon with tweezers in his hands and a gigantic scanning electron microscope attached to his head.

They need to come up with a way to "disable" AR

So just like SERM's do with estrogen, only on the androgen receptor and at the scalp. There could be a reason this is impossible. For instance, if the AR's in the scalp were somehow indistinguishable chemically from the AR's elsewhere in the body, you wouldn't be able to selectively target scalp AR's. Out of all these new fancy experimental chemicals, none of them bind to the androgen receptor without activating it?

If so, I don't see why using one of those as a topical wouldn't do exactly what you're saying.

Also, it's a good thing this forum doesn't have a rule against us hijacking this thread. ...does it?

[2020]

You probably don't actually mean that either, but I just thought the idea of physically removing an androgen receptor looked silly. Picturing a surgeon with tweezers in his hands and a gigantic scanning electron microscope attached to his head.

pretty sure there are much much easier ways of disabling and killing off AR permanently... can't be more complicated than whatever Replicel is doing at the moment

[neversaynever]

pretty sure there are much much easier ways of disabling and killing off AR permanently... can't be more complicated than whatever Replicel is doing at the moment

You 100% those receptors are not needed?

And doesnt the body have the ability to create new receptors?

[2020]

You 100% those receptors are not needed?

10^99 % sure

As I explained: this is just another human flaw that should be fixed at an early age like tonsils and circumcision.... why can't they do the same with AGA?

And doesnt the body have the ability to create new receptors?

yeah but so what, I'm sure they could find a way to disable them permanently... probably much less complicated than what they're doing now.

No need to research through the whole ****ing gene tree to find "MPB gene"... the problem is right here - ANDROGEN RECEPTORS!

[yeahyeahyeah]

10^99 % sure

As I explained: this is just another human flaw that should be fixed at an early age like tonsils and circumcision.... why can't they do the same with AGA?



yeah but so what, I'm sure they could find a way to disable them permanently... probably much less complicated than what they're doing now.

No need to research through the whole ****ing gene tree to find "MPB gene"... the problem is right here - ANDROGEN RECEPTORS!

How would you know - are you a scientist?

[2020]

How would you know - are you a scientist?

how would I know what? that AR are responsible for hair loss?

[WillhasWill]

how would I know what? that AR are responsible for hair loss?

Yes, that's what yeahyeahyeah was asking. And I'll second that. What makes you so sure it is this simple and do you have any method in mind of how to get rid of AR's on the scalp permanently?

[2020]

Yes, that's what yeahyeahyeah was asking. And I'll second that. What makes you so sure it is this simple and do you have any method in mind of how to get rid of AR's on the scalp permanently?

probably not that complicated... either way, with decades and decades spent on hair cloning trying to find the "right cells", they should just focus on solving the main problem(something medicine NEVER does) -> disabling androgen interactions with hair follicles

[damielmillo]

10^99 % sure

As I explained: this is just another human flaw that should be fixed at an early age like tonsils and circumcision.... why can't they do the same with AGA?



yeah but so what, I'm sure they could find a way to disable them permanently... probably much less complicated than what they're doing now.

No need to research through the whole ****ing gene tree to find "MPB gene"... the problem is right here - ANDROGEN RECEPTORS!

And do you think that S-Equol can kill the Androgen receptors??

[UK_]

Im especially impressed at the fact that Anthony Atala believes this can lead to a better form of cell therapy for hair loss, which nobody has mentioned yet.

Any more info on why Atala made that comment other than him working in the same field? Is he also working with the Tokyo researchers to develop a cell based therapy because that would be beyond incredible if it were true!... but I doubt it..

[2020]

And do you think that S-Equol can kill the Androgen receptors??

no... nothing at the moment can't and probably nothing will ever will because medicine always picks the most complicated and indirect way of solving any problem - case in point: Tokyo Guys, Gho...

[damielmillo]

So, S Equol only will work like Finasteride?
I think at least S Equol may mantain the existing hair !!

[2020]

So, S Equol only will work like Finasteride?
I think at least S Equol may mantain the existing hair !!

finasteride binds to 5AR
equol binds directly to DHT

they're very different

[UK_]

@2020 Yes but we would rather have something that blocks the GPR44 receptor - DHT is old news.