Tweet
Originally posted by Highlander
Just sayin
-
Abraham went a little further than that.
Just sayin -
LOLOriginally posted by Highlander
10charComment
-
Dear David
Thank you for your e-mail.
We are very glad you interests in our study.
Our research aims to generate an organ by the transplantation of a
bioengineered organ and organ germ in vivo for organ replacement
regenerative therapy. The regenerative therapy is expected as
next-generation regenerative therapy, or the ultimate goal of regenerative
therapy.
At present, this is still in the fundamental research phase, but many
researchers including us are working hard toward practical use. Therefore,
it is expected that over 10-20 years are still needed for a practical
application.
Please read the attached file.
Sincerely yours,
Takashi Tsuji, PhD
Professor
Research Institute for Industrial Science and- Technology Tokyo University
of Science
2641 Yamazaki, Noda, Chiba 278-8510Comment
-
This was on the file.
Dear David,
Thank you for your contact regarding our recent study published in Nature Communications.
I am grateful to hear that you have interests to our work. We would like to contribute to cure not only the various alopecia patient but also organ insufficient patients through the development of the technologies for the future organ replacement regenerative therapy. We have successfully demonstrated the just proof-of-concept to realize the hair regeneration therapy. We are now making efforts to realize a clinical application in near future.
To realize the clinical application of human hair regeneration, the epithelial stem cells, which are isolated from bulge region, should be amplified by in in vitro culture to increase the number of the bioengineered hair follicle. Furthermore, we should elucidate the potential and safety for the regeneration ability of various follicles isolated from human skin and scalp. To realize the future clinical application for alopecia, many hurdles should be overcome in further studies.
Thus, we cannot perform the clinical trials for this treatment at present. We would like to carry our research to clinical study within three to five years and provide clinical application method for the patients within 10 years.
Thank you again for your encouragement. Sincerely,
Takashi Tsuji, PhD
Professor,
Research Institute for Science and Technology Tokyo University of Science
Director of Organ Technologies Inc. Yamazaki 2641, Noda, Chiba 278-8510 Japan TEL: +81-4-7124-1501 (ex. 4407)
FAX: +81-4-7122-1499
Research Institute of Science and Technology 2641 Yamazaki, Noda, Chiba 278-8510, JAPAN TEL: +81-4-7124-1501 (ex 4407)
FAX: +81-4-7122-1499
November 15, 2012Comment
-
So pretty much they have to figure out how to multiply your:
- Stem cells
- DP cells
- Epidermal cells
- etc.
I know that just recently a university in Japan managed to multiply DP cells without them losing their trichogenicity! That is a huge step forward
Not so sure about stem cells though! Have we been able to replicate them without making them obsolete?Comment
-
So are we saying that not only is this 10 - 20 years away but that it's also not proven to work in humans, only mice? How's Lauster's work in comparison?Comment
-
Great read. Does provide hope, but along with hair, unfortunately I'm running low on time. All these "treatments" I understand take time to market, but at 27 yrs old and jumping half of Norwood every year, it's tough to see the light.
Great read none the less.Comment
-
Why is the hair cloning/ multiplication thread "closed"?
What I wanted to say was "What does everyone think Dr. Lauster is up to nowadays? Have people given up on him?" We have't heard anything but in Dec 2010 he said he'd have something ready in 5 years. I know everyone just rolls there eyes over the 5 years thing but he's reputable isn't he? Anywayz I know Dr. Nigam isn't the best source but he's said Lausters still working on this hasn't he? I wonder why Spencer never interviewed Lauster I mean he interviewed the Atressin B people. My initial response would be that Lauster wouldn't give him an interview but if the guy's got time to give a supposed con like Dr. Nigam a personal tour of his lab then surely he could spend 30 mins to give Spencer a telephone interview.
I would try asking Dr. Nigam on his thread but given that he made up random stuff about Aderans I wouldn't trust what he said.
I wanted to ask people about Lauster cos you all seem more interested in Team Tokyo and I just wondered why.Comment
-
Dr. Lauster's work is basically the grand finale and we're all cured regardless of norwood state. I actually emailed him about a week ago asking about his progress but I haven't heard anything from him. Perhaps you guys could also fire off an email and wait until he cracks about his work?
He's definitely NOT a scam though. I believe his lab is funded by the government and unlike others, hes not a shady businessman but one of the few guys actually doing work in the labs.
Its been over 2 years since we last heard from him so there should be an update soon. Lets hope he didnt pull that 5 year projection and out of his ass cuz we're basically half way there already.Comment
-
hell I just hope he's still working on it and not given up. He must have some serious clinical success though, given that he through out that five year date in 2010...but I just feel like we would have heard from him by now. It's unfortunate and I'm trying to keep hopes up, but we are left in the dark right now with this one. That being said there are many people and many companies working on hair loss right now and we are only going to move forward..we are close to some major break throughs!Comment
-
I believe it's 5 years to figure out all the basic science to grow a hair with his technique. Then he files a patent and only then begins clinical trials.
So based on what we've seen from almost every research endeavor, you have to add anywhere from 2-5 yrs for unexpected delays. So that has us at 7 years and then they can begin clinical trials which should add on another 7+ years. We're looking at 15+ term in the bald penitentiary. That's a helluva long time.Comment
-
To be honest, I personally think Team Tokyo is taking it way more seriously compared to Lauster. Dr Lauster is trying to bring a Pharmacokinetic model for drug testing first before rolling out the hair multiplication technique! That delays things even more for us.
Tsuji Labs on the other hand is actively trying to regenerate hair follicles for transplantation! If you read their paper in detail, they are literally creating "hair germs"; hair germs are formed in the embryo and turn into hair follicles when you are born! They implant 20 of these in a 1cm2 area (which is possible with our current technology and was done in their previous study) and that would give you over 100-120 hairs/cm2!
That is far more than a cure! You literally get the hair density that you had when you were 12!
On top of that, the hairs were multiplied from you donor area, which means DHT would have no long-term effect on them!
They are being funded by the Japanese government and a large regenerative company! They also have over 10 professors specialised in Regenerative medicine working on this project!
I really think pre-clinical work should conclude by 2016 and by 2020 or 2021 we should have this available to public!
2020 may seem far away but at least we won't have to live the rest of our lives bald, right?
Comment
-
Here's a great summary of what they achieved (thx Iron_Man for the find btw)
Here's the key finding:
"28 bioengineered follicle germs were transplanted to a 1 centimeter- (0.39 inch-) circular patch of skin. This was meant to recreate what’s considered a normal hair density — about 120 hair shafts per square centimeter (0.15 square inch) or 60-100 hair shafts per square centimeter.
Within three weeks, the hair follicles implanted with the cells had grown hair in about 70 percent of the tested mice."
This is MIND BLOWING
Comment
-
This is the kind of solution (or cure if you wish) I am expecting. A combination of implantation and multiplication. If they can achieve these rates today, then it has the potential to become a common procedure in ten years from now.
DHT resistance is usually presented only as a guarantee that the hair will be permanent, but anyone in the NW6/7 realm who suffered diffuse thinning knows that it goes beyond that. I mean it has important aesthetic implications. I still remember the changes in my hair when androgens started kicking hard and before aggressive hair loss starts. My hair thinned in a diffuse pattern not only in the sense of density but also in the sense of hair diameter. The hair on the back were always more strong and resistant. Some time later I realized that there were significant differences in the hair diameter also between the two areas (back and top). This explained why the hair on the top seemed more fragile and was more problematic to comb correctly (when I still had it
) than the hair on the back.
Very encouraging. It will take time but for me this is the real hope. It would be nice to have in the meantime another solution, à la Histogen, but this still seems far fetched.
Which are exactly the stages they need to go through before releasing anything as a hair loss cure?
Right. By then I will be in my 50's but, anyway, better late than never.
Comment
Comment