FGF5 inhibition

[Rogerrabbit]

http://advangen.com.au/

Hey guys would someone in Australia please check this one out; this biotech company called Cellmid claim that inhibiting FGF5 in the scalp can indefinitely extend the growth phase of hair. What if we could get a topical that inhibited DHT, PGD2 and FGF5??

[Rogerrabbit]

http://www.cellmid.com.au/SiteMedia/w3svc921/Uploads/Documents/Maeda_2007_Sanguisorba%20Officinalis%20Root%20Extract%20Has%20FGF-5%20Inhibitory%20Activity%20and%20Reduces%20Hair%20Loss%20by%20Causing%20Prolongation%20of%20the%20Anagen%20Period.pdf

Here's a Japanese study they're basing their claims on.

[Ibrium]

I believe it's the exact same thing as Evolis, which has been approved by the TGA (Australian equivalent of the FDA for drugs/medical claims). I'm planning on trying it out some time soon. I'm not sure why FGF5 has gotten no attention from anyone but this company, though, if it's such a big deal.

[matlondon]

maybe if you had a few posts i would try it.

[Davey Jones]

Two first time posters in a row, too. Is this substance present in pure anaconda oil, by any chance? Perhaps cobra? If not, then definitely one of the constrictors.

[TrueGround]

Yea, Anaconda oil would be best. Thanks mates!

[Ibrium]

...Okay, let's put aside for a moment the idiotic fallacy of completely discarding a product solely on the basis of how active someone posting about it has been on this particular forum. (Never mind that the poster registered over a year ago, and posting isn't a requirement to be here. Personally, I've only lurked to get the information I need, as I don't have much to add to most conversations.) I mean, I can see that's the sort of ad hominem argument you're going for here, but it doesn't even make sense, because nobody here is even advocating the product (which is only available in a couple of countries). So why would "suspicious" accounts matter in the slightest?

All I did was repeat information I got from another hair loss forum, because I'm also curious, and figured that it would be as good to collect as much information as possible so that someone who knows what they're talking about can comment on it.

However, as I said in the first place, I am also somewhat sceptical because I haven't heard of FGF5 from anywhere else, and for some reason, no other companies seem to be focusing on it. That doesn't mean I'm not willing to try something I can easily access, particularly given that it had to go through trials to prove its efficacy to get TGA approval. This also makes it worth questioning and discussing, as far as I'm concerned.

Can someone who isn't going to be an asshole, and who is willing to actually read the studies on those sites, give their thoughts?

[Rogerrabbit]

Dude, you took the words out of my mouth!

It does look like a long shot but the principles of scientific inquiry would demand keeping an open minded skepticism.

Thanks for saving me the 20 minutes it would have taken to compose a fitting reply to those charming gentlemen!

[Hair Bear]

These products are extremely expensive and possibly overpriced but artificially inflating prices are what Australians do best.

Has this been proven to work at all on human beings or just receive a tga approval based on its safety, there are plenty of things that work on mice that do not on humans. I have little confidence in the TGA considering leimo is still able to market their led flashlight as a valid method of hair regrowth.

[Ibrium]

It looks like there's at least one human study as well. Which I would hope is necessary for approval... They can't claim that it's proven to prevent hair loss if they haven't done so. I can't find all the details, though.

The overpricing is just to be expected in Australia, so I don't find it that surprising. Rogaine is really expensive as well, but that's been around for years and has generic versions.

[rdawg]

I wouldn't mind seeing some clinical trial results on this "evolis" thing. I can't find much on it online which is curious. Why wouldn't balding australians be going nuts over it if it works?

When I see something this expensive and not being talked about it just gives me a red flag, I need more info on it.

[Hair Bear]

I'm from Australia and haven't heard zip from this company and its quite disappointing that I am learning about this now and by someone online.

"It looks like there's at least one human study as well. Which I would hope is necessary for approval... They can't claim that it's proven to prevent hair loss if they haven't done so."

Honestly I've been around for a number of years and have seen a lot and the more I see the bitter one gets, you would think that such claims are impossible but it is done all the time and if you want any sort of example of that just open up one of these threads this the website of said product and find yourself more absurd claims, in Australia alone we have advanced hair commercials claiming to have completely defeated hairloss... yet we are all still here dwindling away our time on these forums, I guess the TGA and other governing bodies weren't aware of such commercials being cast live on tv all the time or leimo and their amazing led flashlight.

[Pate]

This won't help at all for MPB.

- flash, glib advertising
- contains 'herbal extracts'
- claims like "helps prevent hair loss and assists in maintaining healthy hair"
- nobody's ever heard of it before

Take with several grains of salt.

I note in the FAQ they say:

"Advangen’s products do not affect the growth of vellus hair"

In other words, no good for MPB. Save your money, baldies.

[Ibrium]

I wouldn't mind seeing some clinical trial results on this "evolis" thing. I can't find much on it online which is curious. Why wouldn't balding australians be going nuts over it if it works?

Because nobody has heard of it. You can't buy it anywhere except the website yet, and they've done nothing to market it.

And I doubt the results are especially amazing. It's clearly not a substitute for finasteride or other DHT inhibitors. But extending the anagen phase would be a good thing, and the studies seem to indicate that it does do this - there's certainly clear evidence that some of the ingredients they use do what they claim, though that's not the case for all of them. Not saying the criticisms being raised aren't valid, but has anyone looked at those studies?

I'm curious as to what other TGA-approved hair loss products there are, though, for the sake of comparison.

[Rogerrabbit]

found the active on amazon

http://www.amazon.com/s/ref=nb_sb_noss?url=search-alias%3Daps&field-keywords=MW5734c

Could this be made into a topical?