Prostaglandin Graphic

[youngin]

So just to be clear, you are saying that the PGD2 and DHT are not in the blood that is delivered to the sides of your head? But they are in the blood that is delivered to the top?

[gutted]

So just to be clear, you are saying that the PGD2 and DHT are not in the blood that is delivered to the sides of your head? But they are in the blood that is delivered to the top?

thats not what im saying...of course they are.

if anything dr costerlais research has created more questions than it has answered.

dht-> cox2 -> pgd2

for one reason or another the follicles at the top seem to be heavily affected by dht-> cox2 ->pgd2.

dht->cox2->pgd2 is present in ALL hair follicles.

[youngin]

In the study it says "We show that prostaglandin D2 synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA.". I wonder if they meant follicle instead of scalp. Obviously the cure is in the follicle, or else hair transplants would not work. Maybe hair follicles on top of our head have more GPR44 receptors.

[idw2bb]

In the study it says "We show that prostaglandin D2 synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA.". I wonder if they meant follicle instead of scalp. Obviously the cure is in the follicle, or else hair transplants would not work. Maybe hair follicles on top of our head have more GPR44 receptors.

Does not part of the scalp accompany the follicle in a hair transplant? Is there not evidence of cross-talk between internal and external components of the scalp hair follicle?

[youngin]

As usual scientists and doctors are just coming up with treatments, not cures. Oh it must be too much DHT, lets block it all and screw with your whole endocrine system. Oh its PGD2, lets figure out howto block it. The problem is in the follicle. Why cant someone just figure this shit out. We don't have the technology to accurately compare 2 hair follicles?

[greatjob!]

So is everyone saying that the follicles CRTH2 receptor is uptaking PGD2 and causing the hair not to grow? If that's the case, then why do only the follicles on the top of our heads do it, not the sides? The same amount of PGD2 would be running through our blood to the sides of our head.

prostaglandins are found in tissue. They don't need a dlood supply to migrate somewhere in the body.

[idw2bb]

As usual scientists and doctors are just coming up with treatments, not cures. Oh it must be too much DHT, lets block it all and screw with your whole endocrine system. Oh its PGD2, lets figure out howto block it. The problem is in the follicle. Why cant someone just figure this shit out. We don't have the technology to accurately compare 2 hair follicles?

I agree totally. Would not a COMPLETE comparison between donor and recepient sites in an AGA victim versus a COMPLETE comparison between a "lucky sob" without AGA not yield some results? How about comparing the two? Surely a comprehensive analysis would yield something! You would think that balding, in a pattern, would be easier to define if it were simply and only determined by a gene.

[gutted]

I agree totally. Would not a COMPLETE comparison between donor and recepient sites in an AGA victim versus a COMPLETE comparison between a "lucky sob" without AGA not yield some results? How about comparing the two? Surely a comprehensive analysis would yield something! You would think that balding, in a pattern, would be easier to define if it were simply and only determined by a gene.

if baldness was a deadly disease it would be "cured" tomorow.

comparisons have been done with regards to 5 alpha reductase activity between differnet regions of the scalp as well as hormonal profiles of aga victims against non aga victims.

baldness is not genetic as you are being taught.

Dormancy is a cancer prevention mecahanism used by the body in times when over expression of cox2 enzymes gets over the limit the body decides to shut down production to prevent cancer.
In effect - baldness is your bodies way of stopping you from getting folliclular cancer!

[Dazza]

As usual scientists and doctors are just coming up with treatments, not cures. Oh it must be too much DHT, lets block it all and screw with your whole endocrine system. Oh its PGD2, lets figure out howto block it. The problem is in the follicle. Why cant someone just figure this shit out. We don't have the technology to accurately compare 2 hair follicles?

incorrect...

Also with fin there not blocking DHT there lowering it, even in not AGA scalps DHT is there

Also there not blocking PGD2 there talking about stopping the elevated PGD2 from binding to the CRTH2 Receptor.
PGD2 is just one of the Prostaglandins..

its not the follicles thats the problem its the environment within the scalp

[youngin]

Dormancy is a cancer prevention mecahanism used by the body in times when over expression of cox2 enzymes gets over the limit the body decides to shut down production to prevent cancer.
In effect - baldness is your bodies way of stopping you from getting folliclular cancer!

So your suggesting that >50% of men in the world at some point in their life have mutated cells covering the top of their head in similar patterns? Highly doubtful. Nice theory though.

[youngin]

incorrect...
Also with fin there not blocking DHT there lowering it, even in not AGA scalps DHT is there

Fin binds to selective testosterone, hence blocking it from the receptor. Look at the side effects of Fin. They are the same as low testosterone or high estrogen for a reason. Our endocrine system is a very complicated system, which doctors do not completely understand. Yet they pretend to understand it, and throw some drugs at you with some warning labels and hope for the best. It may very well reduce/block DHT and help with baldness... and it may very well do 100 other things to your body they don't understand.

its not the follicles thats the problem its the environment within the scalp

If it was the environment then FU wouldn't work. PERIOD.

[gutted]

So your suggesting that >50% of men in the world at some point in their life have mutated cells covering the top of their head in similar patterns? Highly doubtful. Nice theory though.

i didnt say that, i said hairs going into dormancy is a cancer protection mechanism. i didnt say bald heads are covered with cancers...

in simple terms baldness is due to over expression of cox2 initiated by androgens.
over expression of cox2 is known to cause cancer.

[gutted]

If it was the environment then FU wouldn't work. PERIOD.

HT's are only perceieved to work...

the men who get ht's are usually men in their 40-50's..those mens hormonal profile natrually declines with age thus reducing the possibility of transplanted hairs being damaged due to excess dht/androgens.
This is the reason why ht's work and the reason why the rate of hair loss declines with age and the reason why some mens hair loss stops at nw2.

If you got a hair from the donor regions and pumped it full of dht, you will almost certainly see them minutuarise.

[youngin]

in simple terms baldness is due to over expression of cox2 initiated by androgens.
over expression of cox2 is known to cause cancer.

Yet the Androgen receptors on the back of our head aren't susceptible? Sounds like you are trying to point to inflammation as the culprit like others do. How do you explain the marked difference from top and back of our heads though?

[youngin]

HT's are only perceieved to work...

the men who get ht's are usually men in their 40-50's..those mens hormonal profile natrually declines with age thus reducing the possibility of transplanted hairs being damaged due to excess dht/androgens.
This is the reason why ht's work.

If you got a hair from the donor regions and pumped it full of dht, you will almost certainly see them minutuarise.

Oh C'mon. Show me some proof of that please. Not ALL men's levels drop extremely low. You don't know how many of those men take testosterone. Also, there are younger men with HT's. And if your theory was correct, then men wouldn't be balding as they got older would they? Cause they lack the DHT to create the environment for balding since their testosterone count is so low. But its quite the opposite.