PGD2 or DHT

[gutted]

DHT competes for the androgen receptors with progesterone. Also, cortisol downregulates the activity of 5a reductase. Progesterone and cortisol belong to the same production line. It's all said in that thread i made. A diet with frequent insulinic spikes and high carb consumption (ANY USDA-recommended diet, aka the "healthy" diet) causes the body to slow down its metabolism to compensate, which causes a reduction in overall metabolic hormone levels, which upregulates DHT. The body then tends to fight excess serum DHT with estrogens, but tissues like the hair follicles and the prostate can make their own DHT(supposedly), which would explain the link. Also, metabolism naturally slows down in aging men (until you get the hormonal crash known as andropause). Furthermore, a BMI that's anything more than "perfectly lean" sharply upregulates TNFa, which a recent research links to PGD2 action.

some supporting research:

http://www.jle.com/en/revues/medecine/ejd/e-docs/00/01/89/4F/article.phtml

http://jcem.endojournals.org/content/57/3/671.abstract

http://jme.endocrinology-journals.or.../41/3/165.full

what i want to know is why cholesterol lowering drugs cause hairloss.

[Aston]

what i want to know is why cholesterol lowering drugs cause hairloss.

Just notice how cholesterol is the starting point of steroid production. http://upload.wikimedia.org/wikipedi...enesis.svg.png

And that representation is grossly incomplete!

Also, it's useless to reply to 2020's troll posts...
Some people can only understand one concept at a time. If you mention diet and metabolism, genetics cease to exist and every fat guy becomes a perfect way to debunk actual logic. Either that or someone's paying them.

Edit: mineral deficiencies can cause a decrease in hormone production as well (Zinc is the famous one). You can eat the perfect USDA healthy diet and have leaky gut (due to grain toxins) and therefore chronic inflammation and autoimmune disorders, coupled with mineral deficiency due to soil depletion and low cholesterol due to the nutritionist scare...

[2020]

probably not due to your family hostory of baldness, you have an excess number of sebaceous glands in your scalp skin.

he also probably has inestinal bacteria that can produce eqoul.

ok so what's the non-genetic secret that lets those millions of extremely unhealthy people keep their hair?

[gutted]

Just notice how cholesterol is the starting point of steroid production. http://upload.wikimedia.org/wikipedi...enesis.svg.png

And that representation is grossly incomplete!

Also, it's useless to reply to 2020's troll posts...
Some people can only understand one concept at a time. If you mention diet and metabolism, genetics cease to exist and every fat guy becomes a perfect way to debunk actual logic. Either that or someone's paying them.

Edit: mineral deficiencies can cause a decrease in hormone production as well (Zinc is the famous one). You can eat the perfect USDA healthy diet and have leaky gut (due to grain toxins) and therefore chronic inflammation and autoimmune disorders, coupled with mineral deficiency due to soil depletion and low cholesterol due to the nutritionist scare...

intresting diagram.

yeah i know these people are brainwashed.

[2020]

intresting diagram.

yeah i know these people are brainwashed.

what people? Me? How are we brainwashed? There is just too much evidence suggesting that lifestyle has no impact on MPB whatsoever...

I said this before: WHEN ALL YOU HAVE IS A HAMMER, EVERYTHING LOOKS LIKE A NAIL.
You people think everything causes MPB... ****'s sake there is actually a discussion on IH forums going on right now that discusses HOW OCEAN WATER HELPS REGROW HAIR... SERIOUSLY

[gutted]

ok so what's the non-genetic secret that lets those millions of extremely unhealthy people keep their hair?

lol what dont you understand what im saying?

they're scalp skin make up is gentically determined to contain only a few seb glands per cm2!


it could also be something like those people probably having the strain of bacteria in thier intestines that produce eqoul, which help keeps dht levels homeostatic/balanced.

[gutted]

what people? Me? How are we brainwashed? There is just too much evidence suggesting that lifestyle has no impact on MPB whatsoever...

I said this before: WHEN ALL YOU HAVE IS A HAMMER, EVERYTHING LOOKS LIKE A NAIL.
You people think everything causes MPB... ****'s sake there is actually a discussion on IH forums going on right now that discusses HOW OCEAN WATER HELPS REGROW HAIR... SERIOUSLY

lifestyle probably causes many many diseases, the thing with getting evidence to support lifestyle is the cause of these diseases is very very hard to do. how would you do it???

anyway get back to topic, this thread aint about diet.

[gutted]

heres something i found that s very intresting - http://www.ncbi.nlm.nih.gov/pubmed/12581424

it probably explains why nw7's are able to achieve regrowth with benaxoprofen.

it slowly repairs the scarring.
i wouldnt be surprised if blocking cox2 is the answer to scarless healing.

[2020]

they're scalp skin make up is gentically determined to contain only a few seb glands per cm2!

I'm almost positive that the number of seb glands gets to be ACQUIRED from PGD2 or whatever and not your genetics. You didn't have that many seb glands before you started balding...

it could also be something like those people probably having the strain of bacteria in thier intestines that produce eqoul, which help keeps dht levels homeostatic/balanced.

didn't you say that this equol thing wouldn't work yesterday?

[gutted]

I'm almost positive that the number of seb glands gets to be ACQUIRED from PGD2 or whatever and not your genetics. You didn't have that many seb glands before you started balding...

looool



10char

[Kirby_]

yeah i know these people are brainwashed.

[2020]

[gutted]

http://www.centre-clauderer.com/en/cholesterol-hair/index.htm

[Aston]

http://www.centre-clauderer.com/en/c...hair/index.htm

I am pretty sure all of their hypothesis's are rubbish, but yeah, the link is there.
The key is in the production rates. Cholesterol first goes into supporting the cortisol line. If that isn't being handicapped by the thyroid activity, it counteracts DHT.

[gutted]

I am pretty sure all of their hypothesis's are rubbish, but yeah, the link is there.
The key is in the production rates. Cholesterol first goes into supporting the cortisol line. If that isn't being handicapped by the thyroid activity, it counteracts DHT.

any thoeries as to why lowering cholesterol via cholesterol lowering drugs would cause hair loss? this is fact.

they state at the bottom of the page -

"There is a real paradox with anti-cholesterol agents. Some can lead to side effects at scalp level: irritations, pruritus, itchiness and… hair loss ! "

this is also experienced with mpb.