Bitmopost (allergen)

[Conpecia]

Also there will most likely be less sides, a huge factor for many.

[Desmond84]

Also there will most likely be less sides, a huge factor for many.

Hey guys,

Something that worries me about Bimatoprost and Prostaglandin analogues in general is their potential to cause skin pigmentation. A lot of glaucoma patients putting this stuff in their eyes, don't just get their iris colour changed, they also have a pigmented eye lids, which is darker than their natural skin colour.

Now if we're putting much higher doses on much larger areas, the potential for patchy pigmentation is quite high. Now that wouldn't be a problem if you have hair, but what if (what if) for whatever reason you give up on this treatment and you lose your hair. Then you may have pigmentations all over your scalp!!

Let's hope I'm wrong though

[rdawg]

Hey guys,

Something that worries me about Bimatoprost and Prostaglandin analogues in general is their potential to cause skin pigmentation. A lot of glaucoma patients putting this stuff in their eyes, don't just get their iris colour changed, they also have a pigmented eye lids, which is darker than their natural skin colour.

Now if we're putting much higher doses on much larger areas, the potential for patchy pigmentation is quite high. Now that wouldn't be a problem if you have hair, but what if (what if) for whatever reason you give up on this treatment and you lose your hair. Then you may have pigmentations all over your scalp!!

Let's hope I'm wrong though

Well they have to test it for what, 3 years right? I'm sure this will be tested in the trials.

[Person]

http://money.msn.com/business-news/article.aspx?feed=SALP&date=20121030&id=15734030

search bimatoprost

Soo, they still have not analyzed phase 2 results. They will finish analyzing results in feb/march. If results are much better than minoxidil (as expected) then they will start preparing for a phase 3 trial. If not they will start preparing for a Phase IIb trial with a stronger formulation.

Summary: We are about 3 years away from it being on the shelf. So who cares.

[Pate]

Good find, thanks for posting. 3 years still makes it about the nearest treatment on the horizon. Depressing as the thought is.

[Person]

this is so damn annoying. Allergan will have the results analyzed by Jan/Feb, yet they will not share those results until a medical conference in JUNE?!?. I almost feel like big pharma loves to move at a snails pace. I give up on looking for new treatments.

It is a massive waste of time and mental energy.

FACT: No newer treatments will be available until atleast 2019.

[rdawg]

this is so damn annoying. Allergan will have the results analyzed by Jan/Feb, yet they will not share those results until a medical conference in JUNE?!?. I almost feel like big pharma loves to move at a snails pace. I give up on looking for new treatments.

It is a massive waste of time and mental energy.

FACT: No newer treatments will be available until atleast 2019.

2019? Let's not get too crazy. we're looking at 2015 for the early stuff(Bim), 2016-2017 for the crazier stuff(Histogen, aderans etc.)

2019 is 7 years, I dont think any clinical trials with positive results will last that long. If Bim continues with positive results, it's about 2, maybe 3 years away.

[Person]

False.

I have done lots of research on Allergan and Bimatoprost. It is the only treatment I really see happening within 5 years.

1. Data wont even be public until June 2013 for phase II results
2. If it is not significantly better than minoxidil they will do an entire phase IIB study and increase dosage (add 1.75 years)
3. If it is successful they will do a phase III (add 2 years beginning in June 2013)
4. FDA approval + commercializing product (1.5 years).

Therefore,

2017 if the P2 results are promising, which I am confident they will be if all they have to do is beat minoxidil's lousy effectiveness. Minoxidil = rat piss.

[rdawg]

False.

I have done lots of research on Allergan and Bimatoprost. It is the only treatment I really see happening within 5 years.

1. Data wont even be public until June 2013 for phase II results
2. If it is not significantly better than minoxidil they will do an entire phase IIB study and increase dosage (add 1.75 years)
3. If it is successful they will do a phase III (add 2 years beginning in June 2013)
4. FDA approval + commercializing product (1.5 years).

Therefore,

2017 if the P2 results are promising, which I am confident they will be if all they have to do is beat minoxidil's lousy effectiveness. Minoxidil = rat piss.

Confused on your math here. I was under the assumption a Phase III takes one year to complete not two. Also FDA approval takes a maximum of 9 months, not 1.5 years(doesnt take 6 months of commercials on top of that, maybe a few weeks.)

2016 at the latest for bim, you're looking at beyond a worse case scenario. Although I am curious about this IIb, what constitutes skipping IIb and going straight to III?

[Person]

Confused on your math here. I was under the assumption a Phase III takes one year to complete not two. Also FDA approval takes a maximum of 9 months, not 1.5 years(doesnt take 6 months of commercials on top of that, maybe a few weeks.)

2016 at the latest for bim, you're looking at beyond a worse case scenario. Although I am curious about this IIb, what constitutes skipping IIb and going straight to III?

For the Phase 3 time I included the time it would take to forumlate the study, recruit subjects, do the study, and tabulate results.

okay maybe 1 year for FDA approval + commercialization

Phase 2 results will determine if they go to Phase 3 or do Phase 2B trial to improve results.

So....late 2016.


I wish you were right, i have high hopes for Bim. I KNOW it will be much more effective than minoxidil just based on the science behind it and its mechanism of action. Obviously Allergan agrees or the wouldnt spend millions doing these trials.

[Pate]

I agree, bim is the treatment most likely to actually reach the market IMO. 2016 is realistic too. CB is the nearest competitor but prob more like 2017 for that. It would be so good if CB and bim could replace fin and minox, I think nearly every guy could at least maintain and most would have at least some regrowth. And instead of 7 pills and 14 applications a week you are using CB twice a week and bim once a day.

And your dick will still work. It's pretty shameful that it'll be nearly 2020 before we can hopefully consign the dinosaurs fin & minox to the pharmaceutical scrap heap. This crap is 80s technology.

Unfortunately those of us already at high NWs will of course need more, but at least the younger guys coming through will hopefully have a viable treatment to hang on to their hair.

[Person]

[QUOTE=Pate;88057]I agree, bim is the treatment most likely to actually reach the market IMO. 2016 is realistic too. CB is the nearest competitor but prob more like 2017 for that. It would be so good if CB and bim could replace fin and minox, I think nearly every guy could at least maintain and most would have at least some regrowth. And instead of 7 pills and 14 applications a week you are using CB twice a week and bim once a day.

And your dick will still work. It's pretty shameful that it'll be nearly 2020 before we can hopefully consign the dinosaurs fin & minox to the pharmaceutical scrap heap. This crap is 80s technology.

Unfortunately those of us already at high NWs will of course need more, but at least the younger guys coming through will hopefully have a viable treatment to hang on to their hair.[/QUOTE/]

I'm already a NW9 so cluck it.

[Supersixx]

For what's its worth.


The company: Allergan Inc.
Headquarters: Irvine
Ticker: AGN
Employees: 10,800

Leadership: David E.I. Pyott, chief executive since 1998

Revenue: $5.8 billion in 2012

Net income: $1.1 billion in 2012

Stock price: $108.60 at Friday's close

52-week range: $81.28 to $109.31

P/E ratio: 22.8 based on 2013 estimated earnings

Annual dividend: 5 cents, a current yield of about 0.2%

The business

This is the company that makes Botox. The wrinkle-erasing drug is Allergan's top-selling product — with sales expected to reach $2 billion in 2013.

But there's more to Allergan than wrinkle medicine. The self-described "multi-specialty healthcare company" also sells breast implants, a prescription drug that enhances eyelashes, a line of ophthalmic pharmaceuticals and, at least for now, the Lap-Band weight-loss device.

The company reported record sales of $5.8 billion in 2012 and expects robust sales again this year —$5.9 billion to $6.2 billion. Its stock hit an all-time high of $109.31 on Feb. 19]



Let's not forget Allergen. They got deep pockets and a foot in the game.

[rdawg]

Any updates coming for this soon?

Isn't it going into phase III this year?

Still very interested in this, even if it's a simple alternative to minoxidil, the more options the better. You never know what could work well for you.

[Kiwi]

Any updates coming for this soon?

Isn't it going into phase III this year?

Still very interested in this, even if it's a simple alternative to minoxidil, the more options the better. You never know what could work well for you.

If its a alternative with less shedding and no sides I'm going to buy it!!!!