OC000459? (Yes that's its name)

[2020]

average hair loss sufferers will not know about these things, as the only source of education is thier doctor/fda/nhs who most likley are not aware of the dynamics of mpb other than which has been taught for the last decade or so.

i think hair loss sufferers should do thier own research to trueley understand what is behind mpb other than dht and genetics.

surpressing the immune system is not the way forward, identifying what is invoking the immune reactin is the end game cure. surpressing the immune system will lead to all sort sof problems...immune surpressing drugs have been known to cause hair growth on people, but this is dangerous.

supressing immune system you say....

http://www.lowdosenaltrexone.org/

EDIT: lol someone beat me to it. There is already 20+ pages about LDN on HLH:

http://***********/6t3jeal

[2020]

Can someone just briefly tell me the deal with this, it seems its come out of knowhere.

1. So there is a topical that they are currently in the process of producing and it is out in shops in 4 weeks time. Correct? If so which country and where will this be sold, will we need a prescription?

2. They have offered the other forum to try out out and a few guys will give feedback?

3. Can someone tell me the success of this stuff in tests/trials, what percentage of men did it work on and what exactly did it achieve?

Thanks.

wow really?

http://www.medicaldaily.com/news/20120321/9342/hair-loss-hair-men-baldness-protein-prostaglandin.htm

scientists discovered that bald areas have much higher levels of PGD2 then hairy areas.
They also found that genetically engineered mice with high PGD2 levels GO BALD while mice with normal PGD2 levels keep their hair.
They also tested PGD2 on cultured human follicles and found the same - hair shrinks when exposed to PGD2.

conclusion: excessive PGD2 is THE MAIN cause of MPB.

OC000459 will block all of that PGD2 and in theory will reverse baldness. The guy who will be testing it said that it will take another 30 days before this molecule is ready to be shipped. 30 days until the cure! :P

[greatjob!]

average hair loss sufferers will not know about these things, as the only source of education is thier doctor/fda/nhs who most likley are not aware of the dynamics of mpb other than which has been taught for the last decade or so.

i think hair loss sufferers should do thier own research to trueley understand what is behind mpb other than dht and genetics.

surpressing the immune system is not the way forward, identifying what is invoking the immune reactin is the end game cure. surpressing the immune system will lead to all sort sof problems...immune surpressing drugs have been known to cause hair growth on people, but this is dangerous.

True, I phrased that wrong, I'm not suggesting surpression of the immune system. I think that understanding the signalling that is going on and blocking that by competitive inhibitor or the like is going to be key. But I also think there are many more things involved than just dht or pgd2 which is why every month a new study comes out claming a receptor or signaling component may be the key to the cure. I hope this works but I think there is much more involved than just pgd2

[gutted]

the immune system most definatly has everything to do with mpb. I'm not talking about an auto immune disorder, in my opinion dht, prostaglandins, etc are markers that are causing the immune system to attack the hair follicles. Surpressing immune response involved with mpb is definatly going to be involved in the end game cure. Prostaglandin D2 is produced by mast cells which is where histamine is generated, it also recruits Helper T, esinophils and basophils which are all wbc that are the main components of our immune system. Their job is to attack infections, parasites, bacteria, etc.

average hair loss sufferers will not know about these things, as the only source of education is thier doctor/fda/nhs who most likley are not aware of the dynamics of mpb other than which has been taught for the last decade or so.

i think hair loss sufferers should do thier own research to trueley understand what is behind mpb other than dht and genetics.

surpressing the immune system is not the way forward, identifying what is invoking the immune reactin is the end game cure. surpressing the immune system will lead to all sort sof problems...immune surpressing drugs have been known to cause hair growth on people, but this is dangerous.

[sausage]

Can someone just briefly tell me the deal with this, it seems its come out of knowhere.

1. So there is a topical that they are currently in the process of producing and it is out in shops in 4 weeks time. Correct? If so which country and where will this be sold, will we need a prescription?

2. They have offered the other forum to try out out and a few guys will give feedback?

3. Can someone tell me the success of this stuff in tests/trials, what percentage of men did it work on and what exactly did it achieve?

Thanks.

[greatjob!]

the immune system most definatly has everything to do with mpb. I'm not talking about an auto immune disorder, in my opinion dht, prostaglandins, etc are markers that are causing the immune system to attack the hair follicles. Surpressing immune response involved with mpb is definatly going to be involved in the end game cure. Prostaglandin D2 is produced by mast cells which is where histamine is generated, it also recruits Helper T, esinophils and basophils which are all wbc that are the main components of our immune system. Their job is to attack infections, parasites, bacteria, etc.

[2020]

is this stuff supposed to regrow lost hair?

we don't know, although at the very least it should halt MPB permanently

[sausage]

is this stuff supposed to regrow lost hair?

[gutted]

right, MPB is 100% not auto-immune. If it was, you would be getting many other diseases as well since auto immune diseases often come in multiples.

btw: that study only talks about women. In general, women's immune system is much more overreactive and that's why most auto-immune diseases happen mostly to women.

anyways, my guess is that MPB is just your body's normal response of getting rid of hair for whatever reason.

no your wrong...if anything this study proves dht isnt the only factor in balding and probably not the root cause either.

[2020]

alopecia areata like, MPB is also not completey understood and/or misunderstood. But bacteria/pathogens are also thought to be involved as well as the body but for now its classified as an "autoimmune disease"
because researchers have identified that its the body attacking the follciles but they have not researched the hidden/disguised problems

the immune system is definteley involved in mpb

http://www.ncbi.nlm.nih.gov/pubmed/22134564

my view - mpb is not an auto immune disease.

right, MPB is 100% not auto-immune. If it was, you would be getting many other diseases as well since auto immune diseases often come in multiples.

btw: that study only talks about women. In general, women's immune system is much more overreactive and that's why most auto-immune diseases happen mostly to women.

anyways, my guess is that MPB is just your body's normal response of getting rid of hair for whatever reason.

[sausage]

I just googled this stuff, it just said it could be ideal for asthma sufferer's

So not sure what this has to do with hair.

[gutted]

I'm pretty sure your immune system has nothing to do with male pattern baldness....
MPB isn't auto-immune (AA is though), so DHT isn't really "attacking" your follicles....

alopecia areata like, MPB is also not completey understood and/or misunderstood. But bacteria/pathogens are also thought to be involved as well as the body but for now its classified as an "autoimmune disease"
because researchers have identified that its the body attacking the follciles but they have not researched the hidden/disguised problems

the immune system is definteley involved in mpb

http://www.ncbi.nlm.nih.gov/pubmed/22134564

my view - mpb is not an auto immune disease.

[2020]

I'm pretty sure your immune system has nothing to do with male pattern baldness....
MPB isn't auto-immune (AA is though), so DHT isn't really "attacking" your follicles....

[clandestine]

oh that's on the first page on their site:



even when taken ORALLY at high doses (100mg+/daily), it still was shown to be very safe.

I've actually contacted the company to ask if any of the subjects reported an increase of hair growth... awaiting their reply

Good initiative mate, thanks. Let us know if they reply.

As an aside, would it be at all possible to get in on the group buy over at HLH?

[gutted]

Often times, that "something" provoking an immune response is totally innocuous. Think allergies to dust, pet hair, etc. It is an immune overreaction that needs controlled.

I'm not saying that I agree that the immune response is the end game to hairloss treatments; I'm just saying that the immune system itself (and not the cause) is the problem in some cases.

its possible that its bacteria, that lives on your scalp, but overgrows beyond control, provoking the immune reaction and thus scarring of the follcile.

MPB is not so much different from alopecia areata, alopecia areata is also thought to be the body attacking its only follicles, (bacteria have also been implicated) causing hair to shed prematureley this is what is know in MPB as "DHT causing early entry into telogen phase" when truely it is not dht but the body.

your imune system is only doing its job and protecting the body, dont blame the immune system, blame yourself.