OC000459? (Yes that's its name)

[2020]

So you're saying, if this thing actually works... there's no future in this treatment?
How can we be happy about this?

I'm not sure about the future, but for now we'll be stuck making our own batches for at least a couple years until some company decides jump in....
Also: since 2007, cotsarelis has been holding a patent that describes a way of treating baldness by blocking PGD2.... I assume that only HE is allowed to make such product since he "invented" it. Other companies aren't allowed so that's why they haven't even started working at it.

It doesn't matter... the good news is that now we know that baldness is fully reversible - NW7 to NW1 no problem. No need for histogen or replicel.
The trick now is to find the right drugs which the hair loss community is currently doing.
OC0459 is first on the list, we'll see how it works in a month or two

[clandestine]

It doesn't matter... the good news is that now we know that baldness is fully reversible - NW7 to NW1 no problem. No need for histogen or replicel.

I'm sorry 2020, but this is a pretty wild assumption.

How in gods name did we go from blocking PGD2 as a potential viable treatment for arresting hair loss, to 'NW7 to NW1 no problem'? Surely I'm missing something?

[Gjm127]

I'm not sure about the future, but for now we'll be stuck making our own batches for at least a couple years until some company decides jump in....
Also: since 2007, cotsarelis has been holding a patent that describes a way of treating baldness by blocking PGD2.... I assume that only HE is allowed to make such product since he "invented" it. Other companies aren't allowed so that's why they haven't even started working at it.

It doesn't matter... the good news is that now we know that baldness is fully reversible - NW7 to NW1 no problem. No need for histogen or replicel.
The trick now is to find the right drugs which the hair loss community is currently doing.
OC0459 is first on the list, we'll see how it works in a month or two

What's Cotsarelis doing now? I mean, he knows about this since 2007, why isn't he working on a making a drug for it?
It takes approx. 8 years to approve a drug, they haven't done dick yet... They'Re not even doing any trials or ANYTHING...

[WillhasWill]

It doesn't matter... the good news is that now we know that baldness is fully reversible - NW7 to NW1 no problem. No need for histogen or replicel.

What a joke. Nothing you say is credible when you make assumptions like this. Cotsarelis finding shows a potential treatment but the finding didn't show a cure. Possibly might be with further work.

[2020]

What's Cotsarelis doing now? I mean, he knows about this since 2007, why isn't he working on a making a drug for it?
It takes approx. 8 years to approve a drug, they haven't done dick yet... They'Re not even doing any trials or ANYTHING...

Cotsarelis works for Follica: http://www.follicabio.com/

I'm sure they're doing something but since it's a private company they have no obligation to reveal anything to us.... That patent probably raises the value of their company.

I'm sorry 2020, but this is a pretty wild assumption.

How in gods name did we go from blocking PGD2 as a potential viable treatment for arresting hair loss, to 'NW7 to NW1 no problem'? Surely I'm missing something?

because..... that study PROVES that PGD2 is inhibiting hair growth.
A mouse did not grow his hair back until they stopped applying PGD2 on his fur. A cultured human follicle was significantly shortened when exposed to PGD2.

PGD2 alone is the culprit. Not your immune system. Not the androgens.
The only reason PGD2 is there in the first place in non-balding people is to keep other prostaglandins in balance in order to prevent "overgrowth".
Unfortunately for us baldies, our body responds to the inflammation by overproducing PGD2 which then prevents hair from growing.

There has been reports from people who reversed their male pattern baldness by taking strong anti-inflammatories..... such drugs inhibit COX-2 which in turn lower levels of PGD2 so that's why it makes sense that it would work! Check out this thread:

http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=89978&STARTPAGE=1&FTVAR_FORUMVIEWTMP=Linear

about "NW7 to NW1" part: yes, your hair loss is completely reversible. Once you block PGD2 completely, the balance will be shifted to the good prostaglandins and slowly you will regrow everything.
Good prostaglandins grow hair as proven by minoxidil and latisse.

http://www.nature.com/jid/journal/v132/n1s/full/jid201291a.html

We found that in C57Bl/6J mice, the levels of prostaglandin synthases and their products (PGD2, PGE2, PGF2a) were reciprocally expressed during wound healing. PGE2 and PGF2a levels increased during the early phases of wound healing while PGD2 increased during the later stages of wound healing......

In all, these findings demonstrate that PGD2 inversely correlates with hair follicle regeneration implying that inhibition of PGD2 production or Gpr44 signaling pathways may promote skin regeneration.

another coincidence that increased levels of PGE2 and PGF2A has been able to regenerate follicles?

What a joke. Nothing you say is credible when you make assumptions like this. Cotsarelis finding shows a potential treatment but the finding didn't show a cure. Possibly might be with further work.

I see you didn't read the actual study ...

[gutted]

Cotsarelis works for Follica: http://www.follicabio.com/

I'm sure they're doing something but since it's a private company they have no obligation to reveal anything to us.... That patent probably raises the value of their company.




because..... that study PROVES that PGD2 is inhibiting hair growth.
A mouse did not grow his hair back until they stopped applying PGD2 on his fur. A cultured human follicle was significantly shortened when exposed to PGD2.

PGD2 alone is the culprit. Not your immune system. Not the androgens.
The only reason PGD2 is there in the first place in non-balding people is to keep other prostaglandins in balance in order to prevent "overgrowth".
Unfortunately for us baldies, our body responds to the inflammation by overproducing PGD2 which then prevents hair from growing.

There has been reports from people who reversed their male pattern baldness by taking strong anti-inflammatories..... such drugs inhibit COX-2 which in turn lower levels of PGD2 so that's why it makes sense that it would work! Check out this thread:

http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=89978&STARTPAGE=1&FTVAR_FORUMVIEWTMP=Linear

about "NW7 to NW1" part: yes, your hair loss is completely reversible. Once you block PGD2 completely, the balance will be shifted to the good prostaglandins and slowly you will regrow everything.
Good prostaglandins grow hair as proven by minoxidil and latisse.

http://www.nature.com/jid/journal/v132/n1s/full/jid201291a.html

another coincidence that increased levels of PGE2 and PGF2A has been able to regenerate follicles?




I see you didn't read the actual study ...

the question is do you have to keep on using this for life to enjoy the benifits or until the hair has gained its thickness back?

i presume you would only need to use it until the hairs are regenerated at which point if subsequent mintarisation does take place it would be a matter of repeating treatment, to gain bak thickness.

omega3/or EPA is available and can already achieve what your trying to do.
im thinking of starting this as an internal, but im on other things and dont want to blur results.

[clandestine]

Well, this all remains good in theory, but until we're actually able to prove such claims one way or another, these findings are of no tangible use to the hair loss community.

[gutted]

Well, this all remains good in theory, but until we're actually able to prove such claims one way or another, these findings are of no tangible use to the hair loss community.

proving something like this works, is a very long way off.
experimentalists will soon prove/disprove whether this has any benefit at all, and i suspect it will, if everything is done correctly.

[2020]

the question is do you have to keep on using this for life to enjoy the benifits or until the hair has gained its thickness back?

i presume you would only need to use it until the hairs are regenerated at which point if subsequent mintarisation does take place it would be a matter of repeating treatment, to gain bak thickness.

probably that altough I'm fine with using it for the rest of my life especially if it ever comes to a pill form

omega3/or EPA is available and can already achieve what your trying to do.
im thinking of starting this as an internal, but im on other things and dont want to blur results.

internal would be way too weak

[25 going on 65]

Forgive me but I'm very skeptical at the idea that I can order a topical right now that will restore all my hair up to my adult hairline.

Though I can't help but be interested.

BTW, if no company is releasing a treatment based on this science because of Cotsarelis' patent, then that guy is the walking definition of a patent-trolling bastard.

[gutted]

probably that altough I'm fine with using it for the rest of my life especially if it ever comes to a pill form



internal would be way too weak

whats to say the pill form of OC000459 wont be weak too.

besides, tackling the pathogens that cause the excess pgd2 is much more a better approach, this is what niz/keto shampoo addresses...you need to read the following article.

Androgenetic alopecia and microinflammation
Yann F. Mahé,PhD, Jean-François Michelet,MSc, Nelly Billoni, MSc, Françoise Jarrousse, BTS , Bruno Buan, BTS , Stephane Commo, BTS, Didier Saint-Léger,PhD and Bruno A. Bernard,PhD

[2020]

Forgive me but I'm very skeptical at the idea that I can order a topical right now that will restore all my hair up to my adult hairline.

You can't order this topical. It hasn't been made yet

I'm 100% positive if you got rid of excess PGD2, you will regrow hair. Whether this particular drug can do exactly that, that's another question

BTW, if no company is releasing a treatment based on this science because of Cotsarelis' patent, then that guy is the walking definition of a patent-trolling bastard.

he may not be trolling.... his company(Follica) may be using it so it's all fair

whats to say the pill form of OC000459 wont be weak too.

that's why we'll be using it as a topical

[25 going on 65]

Thanks for correcting me 2020.

Can I ask what makes you so sure that eliminating PGD2 can fully regrow hair? What about some NW7 who has had a bare dome for 25 years?
To me it seems like the prolonged miniaturization process might have some kind of lasting impact on follicles' ability to grow proper terminal hairs...but I also have no clue what I'm talking about, so hopefully I'm wrong.

[2020]

Thanks for correcting me 2020.

Can I ask what makes you so sure that eliminating PGD2 can fully regrow hair?
What about some NW7 who has had a bare dome for 25 years?

because when you eliminate PGD2, you're left with two other good prostaglandins: PGF2 and PGE2.
PGE2 actually induces growth factors so yeah overtime it will regrow your hair for sure

To me it seems like the prolonged miniaturization process might have some kind of lasting impact on follicles' ability to grow proper terminal hairs...but I also have no clue what I'm talking about, so hopefully I'm wrong.

it doesn't matter. MPB is not auto-immune or anything so there is no permanent damage.
Your body can make hair grow then shrink then grow back again. It has both of those functions

[25 going on 65]

Well then my body is lame.

Another question I've thought of... how does PGD2 tie in to DHT? For a long time we thought DHT was the main culprit in genetic hair loss, and there's no doubt that reducing it stops, slows or reverses the process. What's up with that?