OC000459? (Yes that's its name)

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  • gutted
    Senior Member
    • Jan 2011
    • 1397

    #76
    Originally posted by WillhasWill
    Most of those are not even related to MALE PATTERN BALDNESS. And you sound so sure that you know the cure a few posts back.....
    the basic physiology and mechanism behind the hair follcile remains the same.
    It just so happens that the causes behind each "disease" is different (or are they?)

    i was involved in the sulfasalazine topic on HLH, my mate is on sulfasalazine for his rheaumotoid arthiritis and i can confirm his hair grows below his original hairline...whethere this is due to the drug or something else is anyones guess though.

    there were some people trying sulfasalazine on the forums, but im not really sure what happened...perhaps brushed it off as bull**** and other people followed based on a single user experience. That being said this is most likley going to be brushed off too, we need carefully planned studies...

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    • WillhasWill
      Member
      • Mar 2012
      • 54

      #77
      Originally posted by gutted
      the basic physiology and mechanism behind the hair follcile remains the same.
      It just so happens that the causes behind each "disease" is different (or are they?)

      i was involved in the sulfasalazine topic on HLH, my mate is on sulfasalazine for his rheaumotoid arthiritis and i can confirm his hair grows below his original hairline...whethere this is due to the drug or something else is anyones guess though.

      there were some people trying sulfasalazine on the forums, but im not really sure what happened...perhaps brushed it off as bull**** and other people followed based on a single user experience. That being said this is most likley going to be brushed off too, we need carefully planned studies...
      Are you on sulfasalazine seeing as you have a friend whose hair grows below his original hairline?

      Comment

      • gutted
        Senior Member
        • Jan 2011
        • 1397

        #78
        Originally posted by WillhasWill
        Are you on sulfasalazine seeing as you have a friend whose hair grows below his original hairline?
        no...im not on it.
        it has some pretty bad side effects.

        Comment

        • Gjm127
          Senior Member
          • Mar 2012
          • 170

          #79
          I am glad that this treatment is under works... I would to order some of this but I'm far too scared of trying out some pill or cream that doesn't have FDA approval...

          Isn't any pharmaceutical company working on this except for this forum guy that asked some lab to make this medicine?

          I mean, this could be THE cure we've been all waiting for so long...

          Comment

          • Tacola
            Member
            • Dec 2011
            • 52

            #80
            And does anyone know when this drug will come out? This that can reduce the bad levels of protein? Does Cotseralis work on this? Or is it Latisse?

            Comment

            • 2020
              Senior Member
              • Jan 2012
              • 1513

              #81
              Those poor mice... this picture says everything:

              Comment

              • NeedHairASAP
                Senior Member
                • Jul 2011
                • 1408

                #82
                Originally posted by 2020
                Those poor mice... this picture says everything:


                dont get it...

                Comment

                • clandestine
                  Senior Member
                  • Aug 2011
                  • 2002

                  #83
                  Originally posted by NeedHairASAP
                  dont get it...
                  Me neither. Was waiting for someone else to say it.

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                  • 2020
                    Senior Member
                    • Jan 2012
                    • 1513

                    #84
                    Mice were shaven.

                    Scientists applied PGD2 daily or whatever on Mouse A
                    Scientists also applied a placebo on Mouse B

                    Mouse A did not grow his hair back while hair grew back completely for Mouse B.

                    Conclusion: your hair WILL NOT GROW BACK until you get rid of PGD2

                    Comment

                    • clandestine
                      Senior Member
                      • Aug 2011
                      • 2002

                      #85
                      Originally posted by 2020
                      Mice were shaven.

                      Scientists applied PGD2 daily or whatever on Mouse A
                      Scientists also applied a placebo on Mouse B

                      Mouse A did not grow his hair back while hair grew back completely for Mouse B.

                      Conclusion: your hair WILL NOT GROW BACK until you get rid of PGD2
                      Cool, curious where you got the picture?

                      And when can we expect something like OC000459 might come to market?

                      Comment

                      • 2020
                        Senior Member
                        • Jan 2012
                        • 1513

                        #86
                        Originally posted by clandestine
                        Cool, curious where you got the picture?
                        This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.



                        Originally posted by clandestine
                        And when can we expect something like OC000459 might come to market?
                        ..... OC000459 is an ASTHMA DRUG. Its makers probably have no plans of "remaking" it to a hair loss drug. For all we know, it may not even be effective in its pill form....
                        CRTH2 antagonists have been around for a while so I'm sure they would have noticed its "hair growing" effects. Somehow the pills are just too weak or something, so we'll probably be stuck making our own topicals as no large pharma company is that interested in making another "Rogaine".....

                        Comment

                        • WillhasWill
                          Member
                          • Mar 2012
                          • 54

                          #87
                          Originally posted by 2020
                          http://www.google.com/patents/US20110021599
                          no large pharma company is that interested in making another "Rogaine".....
                          Why would they not be interested in bringing to market a drug that has less side affects and is more effective than Rogaine? More people would take it.

                          There is a hell of a lot of motivation for new hair loss treatments to come to market.

                          Comment

                          • sausage
                            Senior Member
                            • Jan 2012
                            • 1063

                            #88
                            If this grew back a tonne of hair I am sure someone would make it work!

                            Comment

                            • Gjm127
                              Senior Member
                              • Mar 2012
                              • 170

                              #89
                              Originally posted by 2020

                              OC000459 is an ASTHMA DRUG. Its makers probably have no plans of "remaking" it to a hair loss drug. For all we know, it may not even be effective in its pill form....

                              CRTH2 antagonists have been around for a while so I'm sure they would have noticed its "hair growing" effects. Somehow the pills are just too weak or something, so we'll probably be stuck making our own topicals as no large pharma company is that interested in making another "Rogaine".....
                              So you're saying, if this thing actually works... there's no future in this treatment?
                              How can we be happy about this?

                              Comment

                              • NotBelievingIt
                                Senior Member
                                • Oct 2011
                                • 594

                                #90
                                the only thing that stands out in that terrible black and white scan is that the mouse on the right made a poopy.

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