RepliCel - Spencer Kobren's Follow Up Interview With CEO David Hall

[Penny Stock]

Because the process has two proposed mechanisms, both rejuvenation of damaged follicles and follicular neogenesis. We don't actually know how well each will work in humans.

If the neogenesis works well enough to be a viable treatment (as opposed to just incidentally growing a new follicle here and there) then sure, you'd assume the results are compoundable and multiple treatments would be worthwhile.

But there are just so many unknowns in going from mouse models to humans.

Of course I'm not disagreeing with you, there are so many unknowns in going from mouse models to humans, that’s why researchers like ADERANS RESEARCH use human donor skin tissue from i.e. scalp reductions, face lifts and hair transplants, to inject the cultured cells into.

So although WE have no Idea how well it will work on human tissue, Id say with reasonable confidence that Replicel do, the scientists Hoffman etc. have their own money invested in this. Why on earth would you try and compete with a multimillion dollar company like ADERANS RESEARCH if you weren’t certain you method was better?
It wouldn't make sense, and these guys aren’t stupid, if fact there classical geniuses’.

[Thunderbass]

Does anyone know if this will work with traction alopecia?

[Pate]

Just a quick one,

If you inject DSC cells once into an area where there is no hair, ie a mouse foot, and hair grows..... What would possibly suggest that a second injection wouldn't produce more hair?

Just a guess, but I'd say that there is a strong likelihood that the treatment would be compoundable.

Because the process has two proposed mechanisms, both rejuvenation of damaged follicles and follicular neogenesis. We don't actually know how well each will work in humans.

If the neogenesis works well enough to be a viable treatment (as opposed to just incidentally growing a new follicle here and there) then sure, you'd assume the results are compoundable and multiple treatments would be worthwhile.

But there are just so many unknowns in going from mouse models to humans.

[Tracy C]

Are we going to see results on efficacy in q1 2012 or is it just going to be safety?

Mr. Hall stated many times that the current study (phase I/IIa) is for both safety and efficacy. The results we will see in Q1 2012 will be for both safety and efficacy.

And if it is just safety results is that worrisome?

No. It's a requirement.

I understand that using the dermal cup sheath is what sets replicel apart but what part of the formula is being tested? The culture that multiples the cells are a formula that promotes growth when injected?

I'm not sure I understand what you are asking but I think the answer is both.

[Reece]

Couple questions:

Are we going to see results on efficacy in q1 2012 or is it just going to be safety? And if it is just safety results is that worrisome? As far as I know some of these other research firms have shown safety in phases with little documented efficacy, just wondering.

I understand that using the dermal cup sheath is what sets replicel apart but what part of the formula is being tested? The culture that multiples the cells are a formula that promotes growth when injected?

[NotDyingBald]

Easy Dawkins. Don´t misunterstand the post. I actually interpretate it in a positive way mate. it matches with their policy of having nothing to hide and providing all information about hair loss. I think that from the beggining they´ve been saying: "Hey, we´re not better or worse than anybody. This is our investigation and that´s what we pretende to achieve" Hope they keep it when results(positive or not) start to show.

Plus, i think it´s good news, because i´m reaching that point where hairloss is starting to notice, and i´ve been thinking in how to hold on til something good comes up.

Cheers

[RichardDawkins]

Another useless panic BS post. Its just a study to show people something, its totaly without any evaluation.

But if you want it hard you could say they posted it to mock propecia because their product is better whatever

[Penny Stock]

They have presented that article in an objective manner.
“What do you think about their findings?
Is a question that doesn't agree, or disagree with the article, it merely opens a discussion.


That’s how I’d interpret it.

Plus its probably the receptionist posting anyway.

[NotDyingBald]

Replicel´s been using as an advantage for their treatment the argument that Finasteride has side effects. But now they just published this on their facebook page:

http://www.***************/general-h...rc=FB_replicel

How do we interpretate this?

[Penny Stock]

What?

DSC cells are the adult mesenchymal stem cells of the hair follicle.

Feel free to google adult mesenchymal stem cells.


Here's a nice patent for you to read.

http://www.freepatentsonline.com/20060088505.pdf

Here is an excerpt

The cells according to the invention are able and have the characteristic, respectively, unlike the cells of the follicular connective tissue coating (DS) and the dermal papilla (DP), to form a completely new hair follicle or to migrate into a pre-existing hair papilla in order to produce a bigger and thicker hair therewith.

The connective tissue cells at the lower pole of the connective tissue sheath, the so called hair cup cells (DSC), may regenerate all relevant structures of the hair follicle unit formed by the dermis. Due to this feature, they enable the formation of new hair growth or the formation of a thicker hair by population of a small DP. In this case, the life span of the newly formed hair is not limited in time, but may be a lifelong one in principle.

By means of these experiments preliminary investigations could be confirmed that new hair growth is possible by the implantation of DP cells and that only the implanted cells form the new hair, whereas implanted DS cells did not result in the formation of hair but were visible in the dermis as diffuse, GFP expression cell population when using a confocal microscope. Implanted DP cells only led to the formation of a new dermal hair papilla but not to the formation of a follicular connective tissue coating. In contrast, the DSC cells formed both a new DP and a part of the follicular connective tissue (DS) coating. By the fact that the DSC cells may rebuild all dermal hair structures, whereas cells of the DP are not able to do so, it can be deduced that the DSC are less differentiated and more pluripotent than cells of the DP. For this reason, the DSC cells are the adult mesenchymal stem cells of the hair follicle.


If I take for example 1000 DSC adult mesenchymal stem cells, inject them into the dermis where no hair is present or ever has been and 5 hairs are created.

Why wouldn't I have the same result with the next dose of 1000 cells?

[RichardDawkins]

Did you read the postings before? The moment a second shot provide more hair this moment its compoundable.

But follicles are in different cycles thats the reason why it can take longer or shorter for hair to regrow.

But we should wait till march, end of story, no more ass talk and no more panic bullshit

[Penny Stock]

Just a quick one,

If you inject DSC cells once into an area where there is no hair, ie a mouse foot, and hair grows..... What would possibly suggest that a second injection wouldn't produce more hair?

Just a guess, but I'd say that there is a strong likelihood that the treatment would be compoundable.

[RichardDawkins]

Correct hairs and follicles are in different stages of cycling.

Btw if they got even more hair after a second injection you can pretty much assume its compoundable

[Pate]

Nobody knows, Histogen is currently (apparently) running the first trial to check if effects are compounding.

The line of thought (as explained by Histogen) is that not all follicles may be in the right stage of the growth cycle to be regenerated at the same time. So if you have another set of injections six weeks later, a more follicles may be ready to go.

But that is just speculation at this point. Replicel to my knowledge haven't said anything about compounding effects one way or the other. I guess we have to know what one Replicel treatment does before we worry about multiple treatments.

[Jundam]

Nobody here knows anything. They will respond as if they do... be weary because most are assumptions, guesses, and others... just hopes.

To be fair, we know more than nothing. That said, we know very little.

As far as the question goes I expect you won't find an answer in the first phase of the the clinical trials, but the possibility will most likely be tested during the second or third phase.

Waiting is fun.