Replicel

[ccmethinning]

The cells aren't "unmodified", they are unnaturally forcing cells to multiply. Anytime you do this you run the risk of introducing mutations, which could ultimately result in bad things like cancer. The FDA typically only approves drugs or treatments after phase 2 for things that treat serious and life-threatening illnesses that lack good treatments. I think it is really rare for accelerated approval and I think the only treatments that have been approved for release after phase 2 are for rare cancers, so I highly doubt they would approve anything early for hair loss. The only hope for early release is going to be outside of the U.S.

People can say what they want about the FDA or that you would rather be dead than be bald, but if a treatment for baldness caused a serious disease like cancer people would be murdering the company executives. Just look at the back lash for propecia, and that only makes your d*ck limp. Imagine the forum posts and news stories if propecia was causing life threatening illnesses.

There would probably be less backlash if propecia caused death rather than dick limpness lol

[2020]

they don't say anything about Phase 3

http://www.replicel.com/our-science/clinical-trials/

maybe Phase 3 is only required for western markets....

[2020]

These cells are then multiplied many times over in a special patented culture before being injected back into the scalp in their millions, stimulating the formation of new hair follicles or rejuvenating those that have stopped producing hair on the top of the head.

^ what do they mean by FORMATION OF NEW HAIR FOLLICLES?
Do they actually create NEW FOLLICLES FROM SCRATCH or do they just trigger those left over stem cells from dead follicles to start growing new follicles?

[mg39]

^ what do they mean by FORMATION OF NEW HAIR FOLLICLES?
Do they actually create NEW FOLLICLES FROM SCRATCH or do they just trigger those left over stem cells from dead follicles to start growing new follicles?

They claim both, but the "secret sauce" as Hall put it is in the triggering of damaged/miniturized hair follicles.

[2020]

They claim both, but the "secret sauce" as Hall put it is in the triggering of damaged/miniturized hair follicles.

how is that possible??? If a person is predetermined to have 100K follicles, how could they possibly increase that number?? I thought that the best they could is to REVIVE dead follicles and that's it.
What if by accident they inject too much and 50K new follicles start growing. 150K follicles that's going to look ridiculous!

[greatjob!]

^ what do they mean by FORMATION OF NEW HAIR FOLLICLES?
Do they actually create NEW FOLLICLES FROM SCRATCH or do they just trigger those left over stem cells from dead follicles to start growing new follicles?

I don't think they know that yet. Hair follicle cells are just specialized epidermal cells. They are hoping that the multiplied cells will recruit standard epidermal cells on the scalp once injected and cluster together to form new hair follicles. I believe they were able to do this in mice, and there has been success doing this with other cells in the body. It's just a question of if they got it right for this particular cellular process in humans.

[mg39]

how is that possible??? If a person is predetermined to have 100K follicles, how could they possibly increase that number?? I thought that the best they could is to REVIVE dead follicles and that's it.
What if by accident they inject too much and 50K new follicles start growing. 150K follicles that's going to look ridiculous!

That's what the clinical trials are for. Who knows, it may be posturing on their behalf to garner stock interest...if they can tackle MPB from multiple angles to make a cure twice as likely, I can see why people would invest on that principle alone and if only one hits then who cares, they still come up with a cure. Not sure on how it would affect total number of follicles on any one person's head if both scenarios are effective. Maybe there's some sort of natural predisposition to only have a certain number of hair follicles on one's head. Genetics are such a big mystery.

[2020]

Maybe there's some sort of natural predisposition to only have a certain number of hair follicles on one's head.

god I hope so or else the results can look disastrous

[mg39]

god I hope so or else the results can look disastrous

Not sure about disastrous, I think everyone on this forum would want an ultra thick mane of hair vs a runway down the middle

[2020]

Not sure about disastrous, I think everyone on this forum would want an ultra thick mane of hair vs a runway down the middle

right but how could they possibly predict where these new follicles are going to grow? Some spots may end up with more hair than others.

I'd be more than happy if they could reverse all of the MPB damage and bring my hair back to how it looked when I was 13

[Maradona]

right but how could they possibly predict where these new follicles are going to grow? Some spots may end up with more hair than others.

I'd be more than happy if they could reverse all of the MPB damage and bring my hair back to how it looked when I was 13

well in the "rat experiments", the follicles simply seemed to reinforce the already existing small ones.

in the their foot, the follicles were all over the place with no pattern but still limited to a certain radius.

I don't think this will damage your harl IF you have diffuse pattern baldness or your follicles are still "ALIVE" for example by using propecia. Because the cells will simply be in a solution and attach themselves to your existing follicles, and not cluster with each other when they encounter "nothing" useful.

For slick baldness it might be more difficult, who knows, it might not rejuvinate the dead follicles but it will create new ones and this pattern we cannot predict.

I think if there's no such thing as dead follicles and rejuvenation is really possible then the results won't be disastrous, if there's such thing as dead follicles or this treatment can't revive them but simply reconstruct a new one, then they could create new follicles in an unpredictable pattern and really need a huge amount of "replicel's sauce".

This is just my opinion from what i've read guys. I ain't no expert simply a student.

However, aderans and other researchers have tried doing this with different type of cells but it did grow hair,****ed up ones, but it did. Replicel method will work for sure if only if the injection has been done correctly and you have targeted the existing follicles. Wether it'll be significant to hair loss sufferers, we will find out.

On a side note, i said i'd be back in april but i just invested 1k more on replicel so i just keep researching and researching like a mofo, and can't control myself to post here , if i lose the money it's alright im just very excited if i win. in total me and a friend have put 2.5k in replicel, i know it's crazy but i have a good feeling that it works and that's enough to get the stock prices up.

Wether it will bring back all my hair, i don't know, all we can do is hope.

[ffar]

I lost me hope. There won't be a cure in next ten years. I am sorry but all this
"for 5 years" make me sick. I know this board and difrent one... and allways they say 5 years from now. What we know for sure? We don't even know if something works. I have not seen any proising results. Just theory or some pictures that tells nothing. .

[clandestine]

I lost me hope. There won't be a cure in next ten years. I am sorry but all this
"for 5 years" make me sick. I know this board and difrent one... and allways they say 5 years from now. What we know for sure? We don't even know if something works. I have not seen any proising results. Just theory or some pictures that tells nothing. .

Great display of optimism, mate!

[2020]

I lost me hope. There won't be a cure in next ten years. I am sorry but all this
"for 5 years" make me sick. I know this board and difrent one... and allways they say 5 years from now. What we know for sure? We don't even know if something works. I have not seen any proising results. Just theory or some pictures that tells nothing. .

Histogen does work, check their website for pictures. They're on Phase 2 now which studies efficacy so most likely they'll get even better results. 2015 is their date.

Aderans - they had some "weak" regrowth pictures but that was a long time ago. They invested A LOT of money in this and they're conducting many studies at once. They said that they should have something by 2014....

Replicel - we don't know anything yet... They were extremely successful in mice but we'll see how they do it with humans in two months. 2015 also

[UK_]

Aderans stated in a press release in early 2011 that Phase 2 would be finished by spring 2012 - low and behold they've pushed this date back to 2013 now.

When will Histogen have their phase 2 results? Ive heard December 2012, Spring 2012 does anyone have a credible source of information that can answer this question?