Replicel

[bananana]

Replicel is moving at snails pace, they should have started Phase II late last year.

yeah

I thought they started it already. Bollocks.

But at least this time they'll use more than 100 men and this IS effectiveness study. Finally. This means (probably) this time next year we'll know if they're breakthrough of a bust.

ps, the stock is up by 25%!

[UK_]

Replicel is moving at snails pace, they should have started Phase II late last year.

[UK_]

I was reading ylast week of a group of male scientists being able to grow a new nose for a cancer patient - surely... if they're able to grow noses they can harness that ability into regenerating hair follicles? Can they not reproduce skin from the back of the head in the lab yet?

[StinkySmurf]

Nice find! I think they need some more cash, but that doesn't mean they don't have a plan to get it so it's good to see them still moving forward.

[garethbale]

More options is what we need urgently. The best thing that could happen would be a proper 'arms race' between developers of super-treatments.

yeah we need a cold war style hair treatments arms race

[Kirby_]

More options is what we need urgently. The best thing that could happen would be a proper 'arms race' between developers of super-treatments.

[garethbale]

Heading to Phase II Dose Ranging trial... A good sign.

http://www.replicel.com/replicel-to-...uring-process/

good stuff

they are behind Aderans & Histogen, but more options is good

[Kirby_]

Heading to Phase II Dose Ranging trial... A good sign.

http://www.replicel.com/replicel-to-meet-with-german-competent-authority-on-its-rch-01-autologous-hair-cell-manufacturing-process/

[neversaynever]

Hey guys I just thought of something!

You know how I was saying DP and DSC cells are interchangeable!

Now, DSC cells turn into DP cells when the hair is in its anagen (growth) phase! Some DP cells then reconvert back to DSC during resting phase.

What if the reason why Replicel didn't get AMAZING results at 6 months mark was because the implanted DSC cells were not converted to DP cells just yet!

Remember that it is the DP cells that produce all the growth factors and have the Androgen receptors NOT the DSC cells.

Maybe this conversion take longer and should show up in the 24 month follow up!

I personally don't think ALL hope is lost just yet!

Just my 2 cents

I have to disagree with you for once. A partial follicle that contains the upper portion (so no DP) can form a full follicle (including a new DP) well inside a year, possibly just a few months. I guess its possible the 24 month mark might show some gains, but its doubtful. Also, replicel dont plan on showing us the 12 month results? I think that sends quite a clear message. Theyre not dead weight, but they are way behind Aderans, which means the only thing that would save them is a change in their treatment (not likely).

[Desmond84]

Hey guys I just thought of something!

You know how I was saying DP and DSC cells are interchangeable!

Now, DSC cells turn into DP cells when the hair is in its anagen (growth) phase! Some DP cells then reconvert back to DSC during resting phase.

What if the reason why Replicel didn't get AMAZING results at 6 months mark was because the implanted DSC cells were not converted to DP cells just yet!

Remember that it is the DP cells that produce all the growth factors and have the Androgen receptors NOT the DSC cells.

Maybe this conversion take longer and should show up in the 24 month follow up!

I personally don't think ALL hope is lost just yet!

Just my 2 cents

[Pate]

If aderans and replicel announced their results are permanant, they just cured guys who are starting to bald. Im not sure if thatll happen, given the body can signal to create more follicles.

I would love to know what steps (if any) adereans and replicel have taken to check that theory. They extract from the safe zone for that very reason, I wonder how they check it....

Really there is only one way to check it. Photographs and time!

They could probably biopsy the treated area and study it to confirm the follicles aren't susceptible to DHT, but realistically only in vivo studies will confirm it. And that means following guys who have had the treatment over years.

[neversaynever]

I used to agree but I'm actually coming around to the "immunisation from DHT" theory. Given what we know about fibrosis.

We also need to wait and see if the vellus hairs they grew go terminal by 24 months. 20% increase in terminal hair count actually starts to look vaguely interesting, especially if compoundable and permanent.

Replicel need to seriously pick their game up, but I'm not writing them off completely yet. Maybe just 70% written off. :-)

If aderans and replicel announced their results are permanant, they just cured guys who are starting to bald. Im not sure if thatll happen, given the body can signal to create more follicles.

I would love to know what steps (if any) adereans and replicel have taken to check that theory. They extract from the safe zone for that very reason, I wonder how they check it....

[Pate]

Im a positive fellow, but sorry...Repicel are a fail. If all they can do is up the cell dose, it wont work.

We are not mice. Stuff that works on mice wont work on us. This has been proven over and over again.

But at least theyre carrying on, you never know. If they could offer 20% regrowth for $2000 and prove that regrown hairs wont start thinning again...could be a winner.

I used to agree but I'm actually coming around to the "immunisation from DHT" theory. Given what we know about fibrosis.

We also need to wait and see if the vellus hairs they grew go terminal by 24 months. 20% increase in terminal hair count actually starts to look vaguely interesting, especially if compoundable and permanent.

Replicel need to seriously pick their game up, but I'm not writing them off completely yet. Maybe just 70% written off. :-)

[StinkySmurf]

Replicel is Broke

The problem with Replicel is they had only $959,174 in cash as of September, and now it's January so I look for someone else to acquire the IP after they go broke.

[neversaynever]

Im a positive fellow, but sorry...Repicel are a fail. If all they can do is up the cell dose, it wont work.

We are not mice. Stuff that works on mice wont work on us. This has been proven over and over again.

But at least theyre carrying on, you never know. If they could offer 20% regrowth for $2000 and prove that regrown hairs wont start thinning again...could be a winner.