Replicel

[sausage]

They say their results were positive, if its just 6% growth then in the bigger picture how is that positive?

Do they think it will grow loads of hair with in increased dose?

[oracle]

Isn't the Phase I dose an overdose? (Correct me if I'm wrong, somebody!)

I think it is a range of high to low doses. What results did the high doses show?
I'd guess there where 4 or 5 levels in the whole range. Subjects at the high end of the range may show better results. With only 19 subjects, there's not much significance to be drawn on from these results in terms of efficacy.

[WillhasWill]

Isn't the Phase I dose an overdose? (Correct me if I'm wrong, somebody!)

Where have Replicel said they overdosed on this trial? How can they overdose when they do not know the optimal dosage yet?

No dosages have been defined, they are only in phase 1 of clinical trials. Are people confusing an overdose with dose ranges?

[tonypizza]

Why don't they try injecting human hairs onto immunologically neutralized mice, then transplanting the hairs onto human scalps.

If everyone keeps trying the same thing it'll be decades before they finally realize the human scalp is only good at fostering growth of hair follicles at a young age. Something changes as we get older, and the environment is not good for growth of new follicles. That's why these treatments work like magic on mice, but not humans.

Farm the follicles on mice or pigs, and transplant them

[PinotQ]

Ipenergy, Good list......I would like to add that I hope Spencer does not lob a softball on the pennystock-ad-gate issue. Not that David Hall will divulge anything of note but it would be nice to get an explanation of the thought process behind their campaign and, more importantly, I would sure like to read his demeanor and tone of voice when he responds. One more possible interesting question: I wonder what would happen if they injected acell at the time they re-inject the DSC cells. Could acell recruit a missing molecule or two that might make a difference?

[Follicle Death Row]

Horrible results. Almost insignificant statistically. And there was David Hall saying anything above 30% would be a massive success. Time to move on.

I like the lateral thinking of growing follicles on mice and transplanting them. Interesting. I'll take 100 mice please!

[Follicle Death Row]

How did they get funding for phase 2? Quite frankly they don't have results good enough to proceed to phase 2. I don't understand.

[The Alchemist]

As of now the results are:

12.5% increase in Vellus hair
3.2% increase in terminal hair

The fate of those 12.5% vellus will be very important. If they develop into terminal hairs over the next 6 months or so, then they might be on to something. And as IPenegry has noted, there is the possibility that these results could be compoundable. If that's the case, then this would be a good result. But, only if those vellus hairs grow to terminals.

Two things i had a question about before they even started the trial were: at what depth are they making these injections and how far can these cells migrate once injected?

Suppose these cells don't migrate from the site of injection very far, if at all? Suppose that the injection depth used in this protocol is not optimal?

If those two variables were not dialed in correctly for human scalp then it could explain their poor response.

Phase II is going to be an exploratory phase, much the same that Aderans went through. It has the potential to be a long time span. But, i sure as heck hope not.

[eqvist]

Follicle Death Row!!!!!!!!!! MAY YOU PLEASE LEAVE THE REPLICEL THREAD!!!!!!!?
There is a Replicel fail thread for you!

[sausage]

Looks like I will be single forever, either that or I'll have to lump it with an overweight heffer with a hairy muff. Life sucks.

[Supersixx]

Well well well. So bad news afterall....Feel bad for the guys in here that is loosing hope and feel insecure about their going bald. I've seen this coming a mile away and seen so many posters put so much hope and faith in Replicel only to be disappointed.

[Follicle Death Row]

Follicle Death Row!!!!!!!!!! MAY YOU PLEASE LEAVE THE REPLICEL THREAD!!!!!!!?
There is a Replicel fail thread for you!

There is? Ok cool. Thanks for the info.

But seriously, I'm just being a realist. The results are not good. You could easily have those sort of increases or decreases with seasonal sheds.

[Supersixx]

Looks like I will be single forever, either that or I'll have to lump it with an overweight heffer with a hairy muff. Life sucks.

Don't look at what you don't have but what you do have and make it work for you. Girls do it all the time. As for the overweight heffer with a hairy muff....kee in mind that men are outnumbered 6-1 and there are 7 billion people out there...another thing I've learned is that girls tend to like what we think they don't..cheer up.

[Supersixx]

Also a sense of humor TRUMPS anything a person can offer.......

[clandestine]

Horrible results. Almost insignificant statistically. And there was David Hall saying anything above 30% would be a massive success. Time to move on.

I like the lateral thinking of growing follicles on mice and transplanting them. Interesting. I'll take 100 mice please!

Time to move on, indeed.