JAK trial

Collapse
X
 
  • Time
  • Show
Clear All
new posts
  • sdsurfin
    Senior Member
    • Sep 2013
    • 702

    JAK trial

    People are taking 5mg twice daily orally for AA. Just was checking out a forum for people taking Xeljanz(tofacitinib)for AA, and most seem to be getting their hair back of that dosage. They are being very closely monitored though, and the cost is still really high ( i think pfizer is giving discounts, but its still like 12 grand a year) I think somebody on this forum who has AA should get a hold of this stuff, and let someone with mpb trial it topically. It's worth a shot. There's gotta be someone on here with a relative or friend with rheumatoid arthritis or AA as well as mpb.

    The safety has been established enough to show that no one is gonna cause serious harm to themselves short term. The main obstacle right now is the price, but if someone can get their dermatologist to prescribe it for rheumatoid arthritis then it wouldnt even be too expensive. anyone have arthritis?? Anyone have AA? The caveat is that someone with AA might not know if its curing their mpb even if its effective. would be good to have someone with mpb buy it from them and crush it into some vehicle and test it for a month or so. I think if it works it should show signs of doing something. It took quite a few months for some people with AA, but someone on here can probably get a year's supply for not too stepp if they have a compliant dermatologist that can get it for AA or Rheumatoid. I say screw waiting for the scientists. the means are out there to obtain this drug, as it is legal for other things, and making into into a topical solution can't be too hard. we might not get it perfect, but it should be enough to show if it does anything. If someone managed to have success and show pictures, and then send that anonymously to Christiano or just get it out there in the world, drug compaies may be more apt to jump on it. Safety just doesn't seem to be an issue short term especially. Tons of people are using it for AA now off label.

    Interestingly Brett King also just showed that it works for eczema, which is something that I've been dealing with. I think these inflammatory responses are all related, and I think there's a good chance that a combination of these JAK inhibitors and a drug like setipiprant could really make a difference.
  • sdsurfin
    Senior Member
    • Sep 2013
    • 702

    #2
    along the same lines if there's someone rich enough, you can get it from a canadian pharmacy at 22,000 for 60 pills. I can't swing that.

    Comment

    • champpy
      Senior Member
      • Apr 2015
      • 336

      #3
      Do you have a link to the eczema trial?

      Comment

      • sdsurfin
        Senior Member
        • Sep 2013
        • 702

        #4
        I don't sorry, I don't think it was an official trial. Nor are they prescribing it for eczema yet either, it's kinda in the same boat as mpb. just google brett king eczema. I think a topical version of this could be out for AA within the next couple of years though. they already completed a trial that is listed as phase 2, and plenty of doctors are prescribing it already off label, with some cooperation from pfizer. I think it's all in Christiano's court because she holds the patent for using JAK inhibitors for alopecia, so she has to get that rolling for all alopecia trials. My guess is its gonna be a while to get anything realistic even if it works great, but it would be nice to know whether it works or not without having to wait on her lab to publish stuff. right now its within our reach to test it out.

        Comment

        • sdsurfin
          Senior Member
          • Sep 2013
          • 702

          #5
          that dude swisstemples claims to have 5 friends that are already testing it topically and their loss has stopped. Based on what the drug did to DP spheres I have almost no doubt that it will have an effect on any follicle. question is are the side effects gonna be ****ed long term and can they make it in a way that doesnt take 20 more yrs.

          Comment

          • ShookOnes
            Senior Member
            • Jun 2014
            • 209

            #6
            Holy hell that price though.. pfizer is awesome though, tried their anavar and it blew UGL out of the water.

            Comment

            • pixels
              Member
              • Nov 2015
              • 73

              #7
              Originally posted by sdsurfin
              that dude swisstemples claims to have 5 friends that are already testing it topically and their loss has stopped. Based on what the drug did to DP spheres I have almost no doubt that it will have an effect on any follicle. question is are the side effects gonna be ****ed long term and can they make it in a way that doesnt take 20 more yrs.
              What are the side effects?

              Comment

              • UNBEAT
                Member
                • Dec 2015
                • 34

                #8
                WHERE HAVE SPOKE swisstemples FOR 5 FRIENDS USING IT? I WANT TO READ IT.
                I READ AT SITE HAIRLOSS2020 THAT A GUY CAN FIND TOFICIB FOR LOW PRICE IN TURKEY AND WITH A FALSE PRESCITION.

                Comment

                • UNBEAT
                  Member
                  • Dec 2015
                  • 34

                  #9
                  Double post

                  Comment

                  • Link Mahboi
                    Junior Member
                    • Dec 2014
                    • 24

                    #10
                    Originally posted by sdsurfin
                    that dude swisstemples claims to have 5 friends that are already testing it topically and their loss has stopped. Based on what the drug did to DP spheres I have almost no doubt that it will have an effect on any follicle. question is are the side effects gonna be ****ed long term and can they make it in a way that doesnt take 20 more yrs.
                    Question IS : Does it regrow huge amounts of hair like in people suffering from AA? No one in this forum is willing to pay 22k per year only to MANTAIN their crappy hair.

                    Comment

                    • sdsurfin
                      Senior Member
                      • Sep 2013
                      • 702

                      #11
                      Originally posted by Link Mahboi
                      Question IS : Does it regrow huge amounts of hair like in people suffering from AA? No one in this forum is willing to pay 22k per year only to MANTAIN their crappy hair.
                      that's the whole point, we gotta find out. I have a feeling it's not going to resurrect very damaged follicles, but I think bit by bit it could make any hair that you do have, maybe even vellus, a lot better. The amount that it restored genetic inductivity to DP spheres is pretty damn encouraging. that means that this stuff is working directly on hair cells, not just bringing them into anagen, but really making them come alive. The results with AA I'd say were nothing short of miraculous, and if they can find a way to use this without an unacceptable risk of sides (big if) it's gotta do something. I think people go bald for different reasons even under the blanket of mpb, so it will prob help some more than others.

                      Comment

                      • Occulus
                        Senior Member
                        • Dec 2013
                        • 109

                        #12
                        Whatever people do, it should be topical, as the maurine studies showed that it is far more effective as a topical.

                        I'm really disappointed that it took this long for researchers to zero in on this. A decade or more of very strong anecdotal evidence has strongly suggested that AGA is an autoimmune disorder, just like the diseases that JAKs treat. They should have been investigating that hypothesis a long, long time ago.

                        Comment

                        • pixels
                          Member
                          • Nov 2015
                          • 73

                          #13
                          Originally posted by Link Mahboi
                          Question IS : Does it regrow huge amounts of hair like in people suffering from AA? No one in this forum is willing to pay 22k per year only to MANTAIN their crappy hair.
                          Obviously you're not desperate enough yet. You will be if you've been waiting as long as some of the old timer members here.

                          If I could afford $22K a year I'd pay it.

                          Comment

                          • pixels
                            Member
                            • Nov 2015
                            • 73

                            #14
                            Do we know about side effects yet?

                            If this stops your willy from working like propecia than it's not awesome :P

                            Comment

                            • sdsurfin
                              Senior Member
                              • Sep 2013
                              • 702

                              #15
                              Actually much less excited about this now that I learned swisstemples and a bunch of guys tried tofacitinib topically with zero results. Not saying it couldn't be an issue with any number of things, but it seemed to work topically for AA people very quickly. I doubt this is gonna pan out for mpb, although the research into it could one day lead to better understanding i suppose.

                              Comment

                              Working...