JAK Inhibitors and Hair Loss - Dr. Angela Christiano Interview

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  • tbtadmin
    Administrator
    • Sep 2008
    • 988

    JAK Inhibitors and Hair Loss - Dr. Angela Christiano Interview

    Pharmacologic inhibition of JAK-STAT Signaling Promotes Hair Growth

    Spencer Kobren speaks with Angela M. Christiano, PhD about her teamís game changing findings that FDA approved JAK inhibitor drugs induce rapid and robust hair growth when applied topically in both mice and humans. Could JAK inhibitor drugs finally lead to a universally effective treatment for both alopecia areata and common male pattern baldness? It certainly looks promising, and the research community is extremely excited about it.

  • PayDay
    Senior Member
    • Nov 2008
    • 604

    #2
    What can I say? You are the man Spencer! This is very exciting indeed. I hope nothing gets derailed and some big pharma company comes to the plate.

    Comment

    • Delphi
      Senior Member
      • Mar 2009
      • 546

      #3
      Originally posted by tbtadmin
      Pharmacologic inhibition of JAK-STAT Signaling Promotes Hair Growth

      Spencer Kobren speaks with Angela M. Christiano, PhD about her teamís game changing findings that FDA approved JAK inhibitor drugs induce rapid and robust hair growth when applied topically in both mice and humans. Could JAK inhibitor drugs finally lead to a universally effective treatment for both alopecia areata and common male pattern baldness? It certainly looks promising, and the research community is extremely excited about it.

      It's always so much more exciting to hear the "inside baseball" stuff that the media never gives us. This is a really great interview! Let's hope a couple of enterprising doctors start offering some small off lable trials to people who can afford it. I would give it a shot especially since Dr. Christiano said that there will be a very small chance of side effects. Seems like this can really be a great treatment!

      Comment

      • Link Mahboi
        Member
        • Dec 2014
        • 30

        #4
        So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
        God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




        (sorry, had to get this off my chest)

        Comment

        • allTheGoodNamesAreTaken
          Senior Member
          • Aug 2015
          • 342

          #5
          Originally posted by Link Mahboi
          So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
          God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




          (sorry, had to get this off my chest)
          Histogen undeniably works and the necessary trials will be completed in an acceptable timeframe. And it will cost only a fraction of a transplant. And bimatoprost works. And SM04554 seems to work. And Replicel/Shiseido claim a working product and have specified a not-too-distant release date too. Not sure why these facts haven't really been recognised yet but that's what they are. And these things also make transplants a viable option since requiring repeated operations and possibly running out of donor hair won't be an issue. The topic of this video is old news too, it was announced ages ago.

          Comment

          • BoSox
            Senior Member
            • Jun 2010
            • 708

            #6
            Originally posted by Link Mahboi
            So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
            God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




            (sorry, had to get this off my chest)

            I haven't listened to the interview yet. Why? Does she state this will not work for MPB?

            Comment

            • jjo
              Senior Member
              • Oct 2011
              • 110

              #7
              3 to 5 years...again

              too late for many

              Comment

              • Thinning87
                Senior Member
                • Dec 2012
                • 847

                #8
                Relax people.

                Very interesting interview, thank you Spencer.

                Comment

                • champpy
                  Senior Member
                  • Apr 2015
                  • 348

                  #9
                  she was really beating around the bush when it came to answering that question. she did not want to give a definitive answer, although for some reason I think she knows. my guess, and this is my guess only, is that she is trying to prolong this as much as she can to get research money over the next five to ten years. as far as I know she doesn't own the rights to these drugs and wouldn't make any money if this is a cure or a fix. she's only getting money as a researcher, correct? if that's the case then the only way she makes money is by constantly researching.

                  again to me it seems like these rare problems (AA, vitiligo) are what's being addressed but it hits a small percentage of the population. These findings keep everyone interested about the drugs potential but MPB is not being touched. that's because MPB the big payday right and once that solved they are out of a job

                  there has been no information as to what concentration would work in a topical right? I would really love to ask my dermatologist to have this compounded but I have no idea what percentage to use

                  Comment

                  • PayDay
                    Senior Member
                    • Nov 2008
                    • 604

                    #10
                    Originally posted by Link Mahboi
                    So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
                    God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




                    (sorry, had to get this off my chest)
                    Her lab is testing now for AGA. What part of that did you not hear? She's being realistic, but these drugs are the only safe drugs known to man that convert telogen hair into anagen hair and does it rapidly. It's a big deal for both AA and AGA.

                    Comment

                    • ShookOnes
                      Senior Member
                      • Jun 2014
                      • 213

                      #11
                      Originally posted by jjo
                      3 to 5 years...again

                      too late for many

                      Or none if you're on fin...if you're one if those people debating it, only old balding men who are bitter spread the fact it kills dick lol.

                      Comment

                      • Follisket
                        Member
                        • Aug 2014
                        • 61

                        #12
                        ShookOnes, plenty of relatively young guys like me tried fin when they still had a good head of hair.
                        No one's saying it's not worth giving it a shot, but claiming fin doesn't and can't possibly cause severe side effects in some perfectly healthy people is complete idiotism. Take your twattery elsewhere.

                        Comment

                        • doinmyheadin
                          Senior Member
                          • Nov 2010
                          • 129

                          #13
                          Originally posted by PayDay
                          Her lab is testing now for AGA. What part of that did you not hear? She's being realistic, but these drugs are the only safe drugs known to man that convert telogen hair into anagen hair and does it rapidly. It's a big deal for both AA and AGA.
                          I listened to the interview and did not hear her say anything about her lab now testing for AGA (MPB AND FPB). What I got was her saying she was trying to get pharma to fund trials for AGA.

                          If they already tested it on people with AA how hard would it be to find 2 peoople even 1 person with MPB to put it on there head and see if it grows hair back. Im sure theres someone with MPB who works in there lab who would be more then happy to give it a try (maybe the janitor). Then they would have there answer and im sure there will being many investors lining up!

                          Comment

                          • Hemo
                            Senior Member
                            • Apr 2015
                            • 142

                            #14
                            Originally posted by jjo
                            3 to 5 years...again

                            too late for many
                            LOL it's 3-5 years for PHASE I, if (and that's a big if) a pharma company decides to investigate this for AGA instead of areata.

                            These findings don't matter if no companies will trial it.

                            Comment

                            • Hemo
                              Senior Member
                              • Apr 2015
                              • 142

                              #15
                              Originally posted by champpy
                              she was really beating around the bush when it came to answering that question. she did not want to give a definitive answer, although for some reason I think she knows. my guess, and this is my guess only, is that she is trying to prolong this as much as she can to get research money over the next five to ten years. as far as I know she doesn't own the rights to these drugs and wouldn't make any money if this is a cure or a fix. she's only getting money as a researcher, correct? if that's the case then the only way she makes money is by constantly researching.

                              again to me it seems like these rare problems (AA, vitiligo) are what's being addressed but it hits a small percentage of the population. These findings keep everyone interested about the drugs potential but MPB is not being touched. that's because MPB the big payday right and once that solved they are out of a job

                              there has been no information as to what concentration would work in a topical right? I would really love to ask my dermatologist to have this compounded but I have no idea what percentage to use
                              She answered pretty clearly - there are simply no solid plans to look into its effectiveness for AGA. She said a company would have to decide to invest in testing it for AGA, refining its delivery, etc.

                              I would have rather heard her opinion on other drugs in testing (especially Samumed's, since I think she has helped with phase II in some sense). This isn't really much of an issue considering it would probably be 10 years to market if they started testing today (unless they can skip phase I due to the amount of data on Jak inhibitors, but it seems they have limited information on topical delivery).

                              Comment

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