I think I've hacked it

[BaldingEagle]

Actually these ones don't integrate. That's why I said 2 month to one year, one injection would have been enough for the life time. However, integration is unpredictable as a potent promoter may go behind an oncogene and cause cancers. It's an episomal technology, that stays in nucleus for months to years. Depending on the way it was built.

bear with me, haha someday you will know my true identity and you many feel a bit wired for saying these. I never said I have the cure. It'll be an effective treatment, however.

Selling, do you think I would ever do that?! never


Dr. Who?! I don't actually need collaborations as of now, I have enough on my plate.

Tnx everyone, But please don't get your hopes up yet.

By all means continue with your project and prove us wrong. Until then anyone with a brain would be somewhat skeptical.

[FGF11]

Doesnīt AAV integrate rather in a site specific fashion. In other words itīs unlikely to spread in the body on it's own right?

Actually these ones don't integrate. That's why I said 2 month to one year, one injection would have been enough for the life time if integrated. However, integration is unpredictable as a potent promoter may go behind an oncogene and cause cancers. It's an episomal technology, that stays in nucleus for months to years. Depending on the way it was built.

Thank you for curing hair loss, random internet guy with no medical degree!

bear with me, haha someday you will know my true identity and you many feel a bit wired for saying these. I never said I have the cure. It'll be an effective treatment, however.

I WANT TO THANK YOU FGF11 FOR WHAT ARE YOU DOING ANDFOR YOUR TIME TO REPLY TO US.i want to say that if it is possible to let us know if there is any new important update in what you are doing And sell to us guys of BT the cure even it is not fda aproven ...
We are with you

Selling, do you think I would ever do that?! never


Dr. Who?! I don't actually need collaborations as of now, I have enough on my plate.

Tnx everyone, But please don't get your hopes up yet.

[BaldingEagle]

Thank you for curing hair loss, random internet guy with no medical degree!

Medical degree isn't even nearly enough. I have a masters in molecular biology, bachelors in physical chemistry and my brother has a PhD and neither of us whom are both suffering hair loss have any real idea how the exact process works after extensively looking at all known research and pathways.

Trying to cure your natural genetic process without editing the gene itself is far more difficult than these armchair scientists can even comprehend.

It's a miracle we even have things like fin min and dut.

[Seuxin]

Hello,

Don't want to play the Devil's advocate but if you succed to solve baldness, it will cost :

2-3000 / year ( it's a lot !)
You will need to deal with FDA, so...5-10 years ?

[UNBEAT]

I WANT TO THANK YOU FGF11 FOR WHAT ARE YOU DOING ANDFOR YOUR TIME TO REPLY TO US.i want to say that if it is possible to let us know if there is any new important update in what you are doing And sell to us guys of BT the cure even it is not fda aproven ...
We are with you

[fred970]

Thank you for curing hair loss, random internet guy with no medical degree!

[FGF11]

-

[joachim]

What I'm about to do, at the least will be EXTREMELY more effective than fiansteride, RU, and even the post potent anti androgens out there. You don't need to take it daily (but once a year) and it has almost zero side effects.

I'm also building my own start-up, Some very respectable people have actually offered me some money. But I have so much going on in my life. It takes time. But stay tuned. Maybe you hear a news soon in one of the newspapers

man, that's exciting and impressive. i'm glad you have gotten some money to take those things further.

if you can produce some positive results with your technique, probably someone will want to buy your IP or the whole company including you. i hope you don't sell your soul when offered million-dollar-deals from other companies. if you personally have the feeling that you can solve hairloss or at least improve hairloss treatments, please be eager and passionate enough to bring that thing to an end. if your approach is promising you will become a millionaire anyway, one way or another. don't sell your IP for a quick buck. you could make history by beating this decade-lasting nightmare from which millions of people suffer every day.
it's often the case that small startups are bought and their product gets shelved in favor of selling other worthless crap. it happend in the past with many products/IP in many different areas of life.

i wish you good luck with what you're doing. sounds complicated as hell, but i have a good feeling you're a pro at those tasks. keep us in the loop please.

[joachim]

Hey FGF11 why don't you hire some interns man? Sounds like you're pretty swamped. Hopefully you can get a whole operation off the ground, there are a lot of people on these forums that could probably lend a hand in some way, at least on the non-scientific aspect of things. I do think that the only real solution to baldness will come through genetic manipulation. I'm pretty surprised that others are not trying to tackle it from this angle. I wish you all the luck. I'm in contact with Dr. Hsu from the follicept team,he's a very capable scientists, and although I don't think that their approach to hairloss is going to work at all, he might be open to collaborating or helping you find resources if he's swayed by your science. I can't recommend him enough as a person.

excellent idea. they can profit from each other. knowledge sharing is key in many aspects.

i hope, after what FGF11 has written so far, everyone now sees that he is not the usual bro-science guy who just reads some papers and tinkers around.
this guy has incredible knowledge and works with gene editing and other crazy stuff. maybe his idea will not pan out, but the stuff he is trying is more advanced then we could imagine.
i think he has a realistic chance to develop something useful. if not a full cure, at least something better than fin, minox or RU, without the hassle and side effects.

if more users and professionel chemists/scientists would be like FGF11, hairloss would be a thing of the past by now. there are simply too few scientists working actively on hairloss, and most of them are quacks and charlatans which dance around for years with doing decade-long research with no real results.

[sdsurfin]

Hey FGF11 why don't you hire some interns man? Sounds like you're pretty swamped. Hopefully you can get a whole operation off the ground, there are a lot of people on these forums that could probably lend a hand in some way, at least on the non-scientific aspect of things. I do think that the only real solution to baldness will come through genetic manipulation. I'm pretty surprised that others are not trying to tackle it from this angle. I wish you all the luck. I'm in contact with Dr. Hsu from the follicept team,he's a very capable scientists, and although I don't think that their approach to hairloss is going to work at all, he might be open to collaborating or helping you find resources if he's swayed by your science. I can't recommend him enough as a person.

[Swooping]

Yes, they will. AR knockout mice not only have thick hair but regenerate skin much faster.

Also, the reason upon balding skin gets more oily and itchy, is that AR cause lineage differentiation of stem cells from hair follicle towards SG. Anyways, I've got to go.

Doesnīt AAV integrate rather in a site specific fashion. In other words itīs unlikely to spread in the body on it's own right?

I have read papers about prostate cancer wherein AAV-mediated shRNA was used for AR knockdown

AR knockdown would be godly, like really godly.

Long term lasting 100% preventative treatment. AGA would be eradicated. One can only dream and fantasize about that dude..

But... Can you show some pictures dude? Your set-up or anything convincing, more people will take you seriously.

Putting it into practice is on a whole different level.

[Westonci]

What I'm about to do, at the least will be EXTREMELY more effective than fiansteride, RU, and even the post potent anti androgens out there. You don't need to take it daily (but once a year) and it has almost zero side effects.

I'm also building my own start-up, Some very respectable people have actually offered me some money. But I have so much going on in my life. It takes time. But stay tuned. Maybe you hear a news soon in one of the newspapers

God bless you FGF11, your honest to god our only hope in this greedy and corrupt industry.

[lol76]

Best of luck, FGF11 - and thankyou!

[FGF11]

This sounds dangerous as hell. How can you be sure this will be localized to follicles in the scalp? Even totally knocking out AR in sebaceous glands might **** your hair up. Do you even know if hair will grow without androgen receptors?

Yes, they will. AR knockout mice not only have thick hair but regenerate skin much faster.

Also, the reason upon balding skin gets more oily and itchy, is that AR cause lineage differentiation of stem cells from hair follicle towards SG. Anyways, I've got to go.

[FGF11]

This sounds dangerous as hell. How can you be sure this will be localized to follicles in the scalp? Even totally knocking out AR in sebaceous glands might **** your hair up. Do you even know if hair will grow without androgen receptors?

That's where the technology I'm using comes in. My gene delivery consists of infection of genes to the scalp, and activating it later with another mechanism (chemical). That's as much information as I can give now. Also, the whole system is under a specific promoter that is only active in skin.