I think I've hacked it

[Hicks]

I seen a clip of musk speaking and he just about had an under cut and no sign of any work. Wish I could find it

[sdsurfin]

Yes, I'm aware about them.

The first cell therapies for skin was actually developed by Howard Green. He, unfortunately, died. But what he did was, he cultured epithelial human cells in a very specific way. In which, he added the media from under, and layers of epithelia grew out and then he developed autologous cell transplantation. This gave rise to few companies, one of them was named Organogenesis, which developed substitute skins but the company went bankrupt because first. Many of the famous skin biologists today are trained in his lab, including elaine fuchs, which she has trained many others including Dr. Rendl, Dr. Greco, ..

In response to a question, he says the following:

"It's worth noting that at the time we did the initial skin graft experiments, the US Food and Drug Administration (FDA) existed, but they were not interested, and there were no committees whose approval you had to seek. We went ahead with this without any impediments of that sort. Within a few years, I could not do an experiment on a mouse without committee approval, so that's how the situation changed within a short period of time. If I had needed to face that at the beginning, I wouldn't have started the whole thing because it's just too much to deal with."

So even prominent scientist are actually happened by FDA in many ways.

Colin Jahoda, was among the first scientist, who showed that dermal papillae can induce hair follicle regeneration. At the time, he was working at Dr. Reynolds lab, which was a pioneer in hair follicle studies. He has also trained many of Many other scientists, such as Dr. Christiano, which she has Trained Dr. Higgins, and so on. Dr. Jahoda, first transplanted a hair follicle to his wife's hand and showed that dermal papillae can induce hair follicles.

However, later on works from Dr. Mc Elwee showed that derma sheath cells are more important than dermal papillae cells. Dermal papillae cells never actually divide in vivo, so they must come from somewhere. After recent studies, By Dr. Bernieskie, (was trained in Dr. Freda miller lab) he showed that actually Dermal sheath cells contribute to dermal papillae, and dermal papillae is not the important one.


So replicel seems to be on the right track here. Since aderans and intercytex were trying to use dermal papillae (as what Dr. Christiano and Higgins) are trying to do. However replicel is culturing dermal sheath cells.

However, guaranteed it won't work.

Why? you may ask?

Hematopoietic stem cells have been known for 50 years or so, and tons of more research is being done on them for bone marrow transplantation studies. We do have Hematopoietic stem cell for quite a decade now, however, despite 10X more knowledge on them than hair follicle stem cells. Scientists have not yet been able to culture these stem cells. It's not possible. Replicell is on the right track, but it'll take 50 more years for them to learn how to culture these cells. They will differentiate so fast and irreversibly since they are out of their niche.

If some one finds a way to culture Hematopoietic stem cells, he could save millions of people every year. But alas it's not yet feasible. So is hair follicle stem cell culture.


As for cell coating, those are jokes. They are not useful in any sense. The only real use I see, is to some how use them to coast stem cells from other people, or may be embryonic stem cells used by histogen (so these cells would become immune protective) and transplant them back to the hair. So they will secrete growth factors in the head, while the body won't attack them.


This is not something fancy, as viacyte is doing the exact same thing, they're using some one else's embryonic stem cells but they put it in a protective sheet and implant it in the body. They're using it to cure diabetes. They are in clinical trials. As for diabetes, no one has still find a way to replicate those stem cells as well. and we know tons more about beta-cells than any other cells.

So my take, it won't happens soon. Dr. Paul kemp was the smartest and given up on that long ago.

A simple gene analysis will take years if I want to do, and so no I can't do that. Also, I know, even if I try I would fail to keep inductivity of dermal papillae or dermal sheath cells, It's gigantic task.
It's nothing short of miracle.

I feel like we need a fact checker here. All you've done so far is come on here, say you have a miracle treatment that you can't say anything about, provide any evidence for, and then shit on everyone else's work. Maybe you're legit and onto something, but you may just be some obsessive schizo who thinks he knows everything and is just making shit up.

How are coatings for DP cells "useless"?? they just showed in a published paper (where are your publications?) that the coatings restore a huge amount of inductivity to DP cells. Useless? Christiano just showed that she can restore a massive amount of inductivity (she showed proof in photos) to DP cell spheres just using JAK inhibitors, so the idea that they could restore good enough inductivity for hair growth doesn't seem that unrealistic. Tsuji seems to be making pretty solid progress on that front too, and has never mentioned hematopoietic stem cells.

Also what do hematopoietic stem cells have to do with hair? I can't find a single paper that talks about this, and even if they are one of the key stem cell types in the hair follicle, replicel has stated many times that the DSC cells are crucial in maintaining and feeding stem cell populations in the follicle.

Why should we listen to absolutely anything you say, seeing as we have zero idea who you are, what you're up to, or what qualifies you to know more than people like the researchers at replicel. Everything that you've said you could have dug off the internet, except for your big claims that other things won't work, and which you have not elaborated on at all. I wish you luck with whatever your experiments are, but if you're gonna come on here and naysay the work of other scientists who are good enough to be open and public about their work and research, then at least elucidate a bit.

[sdsurfin]

ah i see now you were just likening the culture of Hematopoietic stem cells to hair cells as far as the challenges concerned. I don't think this is a good analogy. Hematopoietic stem cells (HSC) cannot be easily observed directly, and, therefore, their behaviors need to be inferred indirectly. Hair follicle cells can be easily observed and multiplied, and DSC cells do not lose their characteristics. The stem cells in the scalp are always there, and DSC and DP cells work to maintain them. so the challenges are very different than cloning and repopulating hematopoietic cells. It would be much more accurate to compare hair follicle cell treatments to a bone marrow transplantation, which scientists can carry out currently and does work. I don't think anyone is going to restore hair to a bald scalp using replicel's techniques, but where there are already functioning stem cell populations, and weakening hair, DSC cells could in fact restore those stem cells to good use. In this scenario, your comparison to the culture of hematopoietic stem cells in vitro really has no correlation. Also, scientists are in fact working on culturing hematopoietic stem cells in vitro, so even that is not a distant dream.

This is what I'm saying about your arguments. You may be a knowledgeable scientist, but you come on here and make false inferences, and people will believe you because you can throw out fancy terms and unproven ideas. In the end all you are stating are unproven and at best loosely-thought out opinions on other peoples' research.

[FGF11]

I'm not trying to use fancy words. Bone marrow transplantation is more like hair transplantation.

Don't even start me on, Tsuji paper.



What he did is actually not that novel (in the sense of hair follicle engineering and de novo genesis), like not at all. I'm sorry but it's true.

He used Intact human DP to form hair. Guess what Oliver showed decades ago, it's possible to do that. Believe it or not, publishing fancy articles, has a lot to do with how you write the article and mostly not your data.

In another experiment, he used fetal dermal cells, which is known to induce hair follicle. Without the need to co-culture them with Epithelial Bulge stem cells.

I never ever said I have the cure. NEVER. I'm here to introduce real expectations rather than raising false hope.

[FGF11]

I'm not trying to use fancy words. Bone marrow transplantation is more like hair transplantation.

Don't even start me on, Tsuji paper.



What he did is actually not that novel (in the sense of hair follicle engineering and de novo genesis), like not at all. I'm sorry but it's true.

He used Intact human DP to form hair. Guess what Oliver showed decades ago, it's possible to do that. Believe it or not, publishing fancy articles, has a lot to do with how you write the article and mostly not your data.

In another experiment, he used fetal dermal cells, which is known to induce hair follicle. Without the need to co-culture them with Epithelial Bulge stem cells.

I never ever said I have the cure. NEVER. I'm here to introduce real expectations rather than raising false hope.

[sdsurfin]

I'm not trying to use fancy words. Bone marrow transplantation is more like hair transplantation.

Don't even start me on, Tsuji paper.



What he did is actually not that novel (in the sense of hair follicle engineering and de novo genesis), like not at all. I'm sorry but it's true.

He used Intact human DP to form hair. Guess what Oliver showed decades ago, it's possible to do that. Believe it or not, publishing fancy articles, has a lot to do with how you write the article and mostly not your data.

In another experiment, he used fetal dermal cells, which is known to induce hair follicle. Without the need to co-culture them with Epithelial Bulge stem cells.

I never ever said I have the cure. NEVER. I'm here to introduce real expectations rather than raising false hope.

??
Did I even ask about Tsuji? This is what I'm saying, you come on here and throw out some speculative unexplained theory you have going, but do not engage in any kind of discourse when you make overreaching claims about other peoples' work. You ignored everything I wrote, and have no basis for your claims that nothing else will work. Just because what Tsuji is doing is not new doesn't mean it will not work. If anything it's encouraging that he is working to perfect things that we know can possibly be a solution. I think that they are actually very close to maintaining inductivity in hair cells, and from there its really more of an engineering problem than a case of having to publish more papers.

[NeedHairASAP]

??
Did I even ask about Tsuji? This is what I'm saying, you come on here and throw out some speculative unexplained theory you have going, but do not engage in any kind of discourse when you make overreaching claims about other peoples' work. You ignored everything I wrote, and have no basis for your claims that nothing else will work. Just because what Tsuji is doing is not new doesn't mean it will not work. If anything it's encouraging that he is working to perfect things that we know can possibly be a solution. I think that they are actually very close to maintaining inductivity in hair cells, and from there its really more of an engineering problem than a case of having to publish more papers.

SDsurfin, I feel like he has given a decent explanation of his theory and what he is doing.

And he's just pointing out that Tsuji may not be the gods that most non-scientific bald people think.

People who have never published an academic paper think it's the biggest deal in the world... and it is a long-hard process....but it's not really as impressive as most people think once you've done it.

Not saying to ignore papers, just that they should be taken with a larger grain of salt than most would think.

FG11's theory doesn't seem that far out or confusing to me. I couldn't replicate it or explain it in detail myself, but to me, it at least passes the smell test and is worth hearing more about (and doing so politely)

[allTheGoodNamesAreTaken]

For ****'s sake. If it can be tried then try it, document it, come back in a few months or more and post about what happened. All this back and forth speculation is worthless.

[jamesst11]

https://www.youtube.com/watch?v=m84cOOc8-T0 FGF11 have you seen this video?

[sdsurfin]

I'm not naysaying his theory (even though he retracted his entire first approach and now has something else mysterious in the works.) I'm just pointing out that he has pooh-pooed every other team working on hairloss and said that nothing else will work- based on zero factual evidence- and backs it up with nonsense like "constructing hair follicles is not going to happen because Hematopoietic stem cells are better known and have not been used to cure blood diseases". These things do not correlate, they involve totally different cells and sets of challenges. You can't even see hematopoietic stem cells. If you're gonna come on here and slam replicel or Tsuji, then at least give good reasons. If you're gonna come on here and say you have a great idea, then explain it and show some evidence. Otherwise you just crush peoples' hopes without any evidence of what you're saying..

Zero of what he has claimed about other treatments makes any sense whatsoever, and he sure hasn't explained why his is going to work or shown any proof. Everybody knows scientific papers don't mean shit. Everyone knows that the things Tsuji and jahoda and Christiano are working on have been in the works forever. that doesn't mean they arent a lot closer to being able to do real things.

On the flip side, Dr. Robert Hoffman was trying to fix hairloss with gene introduction in like 1995 with no results. I wish FGF11 the best with whatever he's doing, but if his science is only as solid as his writing or his logical analysis of other teams' work, then I doubt he'll get too far.

[UNBEAT]

i think fgf11 has understood the essence of the hair loss problem and he will get far,because this brakethough like hair loss are done by courageous individual reserchers

[NeedHairASAP]

I'm not naysaying his theory (even though he retracted his entire first approach and now has something else mysterious in the works.) I'm just pointing out that he has pooh-pooed every other team working on hairloss and said that nothing else will work- based on zero factual evidence- and backs it up with nonsense like "constructing hair follicles is not going to happen because Hematopoietic stem cells are better known and have not been used to cure blood diseases". These things do not correlate, they involve totally different cells and sets of challenges. You can't even see hematopoietic stem cells. If you're gonna come on here and slam replicel or Tsuji, then at least give good reasons. If you're gonna come on here and say you have a great idea, then explain it and show some evidence. Otherwise you just crush peoples' hopes without any evidence of what you're saying..

Zero of what he has claimed about other treatments makes any sense whatsoever, and he sure hasn't explained why his is going to work or shown any proof. Everybody knows scientific papers don't mean shit. Everyone knows that the things Tsuji and jahoda and Christiano are working on have been in the works forever. that doesn't mean they arent a lot closer to being able to do real things.

On the flip side, Dr. Robert Hoffman was trying to fix hairloss with gene introduction in like 1995 with no results. I wish FGF11 the best with whatever he's doing, but if his science is only as solid as his writing or his logical analysis of other teams' work, then I doubt he'll get too far.

Well, to be fair. All of these teams have been around a long time and nothing has worked.... what more evidence do you need lol?

Of course that's not to say they won't succeed in the future, but their track record doesn't exactly instill confidence and isn't what I'd call evidence against fg11 poo pooing them...

also half of what he's saying is that they don't move fast enough, not so much that their theories are totally flawed.. just that at their pace and given the angles they are taking, they're unlikely to succeed anytiem soon.

[NeedHairASAP]

I'm not naysaying his theory (even though he retracted his entire first approach and now has something else mysterious in the works.) I'm just pointing out that he has pooh-pooed every other team working on hairloss and said that nothing else will work- based on zero factual evidence- and backs it up with nonsense like "constructing hair follicles is not going to happen because Hematopoietic stem cells are better known and have not been used to cure blood diseases". These things do not correlate, they involve totally different cells and sets of challenges. You can't even see hematopoietic stem cells. If you're gonna come on here and slam replicel or Tsuji, then at least give good reasons. If you're gonna come on here and say you have a great idea, then explain it and show some evidence. Otherwise you just crush peoples' hopes without any evidence of what you're saying..

Zero of what he has claimed about other treatments makes any sense whatsoever, and he sure hasn't explained why his is going to work or shown any proof. Everybody knows scientific papers don't mean shit. Everyone knows that the things Tsuji and jahoda and Christiano are working on have been in the works forever. that doesn't mean they arent a lot closer to being able to do real things.

On the flip side, Dr. Robert Hoffman was trying to fix hairloss with gene introduction in like 1995 with no results. I wish FGF11 the best with whatever he's doing, but if his science is only as solid as his writing or his logical analysis of other teams' work, then I doubt he'll get too far.

He has a theory about a protocol that could shut off the AR.

What more is there to explain?

[fred970]

i think fgf11 has understood the essence of the hair loss problem and he will get far,because this brakethough like hair loss are done by courageous individual reserchers

Yeah, f-ck the qualified scientists who are on this. The cure for hair loss will be found in FGF11's basement!

[jamesst11]

Yeah, f-ck the qualified scientists who are on this. The cure for hair loss will be found in FGF11's basement!

It just might Fred, it just might. Sometimes the most intuitive minds and greatest discoveries come from outside the lab. How do you know FGF11 isn't like Matt Damon in, "a beautiful mind"?