-
-
FGF11 any result man? photos to show??? we are waiting man..Comment
-
I've been trying so many different things. It's a one man thing. I'm sorry, I assure you I want to do thin more than probably anyone in the world. If you want a picture though after editing it, I will update the one that I have soon. It's just basically, few black dots showing in a small area that didn't exist before. I don't think any of you will find that impressive, but those of you who are more life tech savvy will know what I'm talking about.
To let you know what I've been up to, remember the problems:
1st) It was very expensive and time consuming to make the siRNA's.
2nd) It needed daily injection so after like a week, you would develop wounds.
3rd) you needed quite a lot of material, and could develop side effects.
Right?
So I've been able to solve all of them, and soon I will try a complete trial on myself.
I'm using a way to permanently deliver genes to my head to kill Androgen Receptor, not just daily injection but once in 2 or 3 month injections. what follows is hard for lay people to understand, so that's why I don't bother updating here, because no one actually knows what I'm writing. Anyways, here is quick update:
I'm using AAV type 2 virus. It's a virus that can efficiency (100%) transfect hair follicles with the gene of interest. I've developed a vector, that has a human shRNA with in it, and it's under a specific promoter, that only get's activated in the skin.
This virus is absolutely safe. It's called Aden-associated virus. A one time injection of this genetically engineered virus will be able to knockout Androgen Receptor for more than a year, so you don't basically need to take any pills or experience side effects for a year. It also will be very cheap may be about 2000-3000 dollar each year.
Something like this, is already being sold, but for research. It's hard to explain what I'm about to do in lay terms, and I won't explain everything here as I'm starting my own biotech start-up actually.
something like this: http://www.vectorbiolabs.com/RVS/shA...n-AR-shRNA-AAV
Three things: I believe in what I do, but you guys should know that a small article you see is published takes four years. I'm just a one person doing my best. But I'm progressing very fast.Comment
-
What I'm about to do, at the least will be EXTREMELY more effective than fiansteride, RU, and even the post potent anti androgens out there. You don't need to take it daily (but once a year) and it has almost zero side effects.
I'm also building my own start-up, Some very respectable people have actually offered me some money. But I have so much going on in my life. It takes time. But stay tuned. Maybe you hear a news soon in one of the newspapers
Comment
-
Holy shit, that is impressive, I hope you will be fine and I wish you success, can't wait to hear from you again.Comment
-
It's very good guy but....what about the FDA process ???Comment
-
Good luck with your start-up. What is your gut feeling?Do you think it will reverse a NW7 to a head full of hair or it will only prevent hair loss in the early stages?What I'm about to do, at the least will be EXTREMELY more effective than fiansteride, RU, and even the post potent anti androgens out there. You don't need to take it daily (but once a year) and it has almost zero side effects.
I'm also building my own start-up, Some very respectable people have actually offered me some money. But I have so much going on in my life. It takes time. But stay tuned. Maybe you hear a news soon in one of the newspapersComment
-
This sounds dangerous as hell. How can you be sure this will be localized to follicles in the scalp? Even totally knocking out AR in sebaceous glands might **** your hair up. Do you even know if hair will grow without androgen receptors?Comment
-
To be honest, my hands are very tight. I would say keeps the hair and thickens majority. But AR is not the only thing that I am playing with, and so I'm going to actually go for complete reversal. But I won't be talking about that. Because I will only confuse you guys, but don't expect anything soon. I'm not going to mention everything here, for many reasons, but AR is not the only gene that I'm playing with.
There are still many many problems ahead.Comment
-
That's where the technology I'm using comes in. My gene delivery consists of infection of genes to the scalp, and activating it later with another mechanism (chemical). That's as much information as I can give now. Also, the whole system is under a specific promoter that is only active in skin.Comment
-
Best of luck, FGF11 - and thankyou!Comment
-
God bless you FGF11, your honest to god our only hope in this greedy and corrupt industry.What I'm about to do, at the least will be EXTREMELY more effective than fiansteride, RU, and even the post potent anti androgens out there. You don't need to take it daily (but once a year) and it has almost zero side effects.
I'm also building my own start-up, Some very respectable people have actually offered me some money. But I have so much going on in my life. It takes time. But stay tuned. Maybe you hear a news soon in one of the newspapersComment
-
Doesnīt AAV integrate rather in a site specific fashion. In other words itīs unlikely to spread in the body on it's own right?
I have read papers about prostate cancer wherein AAV-mediated shRNA was used for AR knockdown
AR knockdown would be godly, like really godly.
Long term lasting 100% preventative treatment. AGA would be eradicated. One can only dream and fantasize about that dude..
But... Can you show some pictures dude? Your set-up or anything convincing, more people will take you seriously.
Putting it into practice is on a whole different level.Comment
Tweet
Comment