Updated Research and Knowledge - Cutting Edge

[jamesst11]

it's hard to tell what's going on this pics? can you take a couple more with your hair combed the same way and at the same angle?

[burtandernie]

Could you take this stuff orally and how much of each thing to get any result? There still is a pretty large number of people looking for that magic fin alternative. I guess I should really try fin before trying all this other random stuff.

[Unsure1]

Where You scalp or sub q injecting tb 500?
Injecting 2-4mg into the scalp weekly I saw minor quality improvement though nothing too significant

[champpy]

Hey Tubzy, can you tell us the source you got the TB4 from?

[Seuxin]

I actually have been using tb500 for the past few weeks on and off. I have taken a few weeks off and now back on 8mg injected one a week. I bought enough this time to run it for at least 6 weeks at 8mg a week. It definitely has an impact on hair color and growth because my hair did look way healthier and darker when I only used it for a 3 weeks in the past . The only downside is the price as it's costing me $31 for 2mg vial but the stuff I have it 100% legit. I heal way quicker too from weight lifting. I just did my first shot again this past Wednesday and plan to keep going for another 5 weeks or more if I have the money.

SO....you're paying 124$ / week for TB500 ???????

[Forestry]

regenerating hair follicles

i have been following (this forum is great, special thanks to Chemical for elaborating your findings) and researching and wanted to add this.

when reading wikipedia on keratinocyte differentiation and the associated expression of specific keratins at each stage, i came to the section on the Role in Wound Healing, and the associated reference:

...Wounds to the skin will be repaired in part by the migration of keratinocytes to fill in the gap created by the wound. The first set of keratinocytes to participate in that repair come from the bulge region of the hair follicle and will only survive transiently... At the opposite, epidermal keratinocytes, can contribute to de novo hair follicle formation during the healing of large wounds.

https://www.ncbi.nlm.nih.gov/pubmed/17507982

"the possibility that hair follicles develop de novo following wounding was raised in studies on rabbits, mice and even humans fifty years ago. Subsequently, these observations were generally discounted because definitive evidence for follicular neogenesis was not presented. Here we show that, after wounding, hair follicles form de novo in genetically normal adult mice. The regenerated hair follicles establish a stem cell population, express known molecular markers of follicle differentiation, produce a hair shaft and progress through all stages of the hair follicle cycle. Lineage analysis demonstrated that the nascent follicles arise from epithelial cells outside of the hair follicle stem cell niche, suggesting that epidermal cells in the wound assume a hair follicle stem cell phenotype. Inhibition of Wnt signalling after re-epithelialization completely abrogates this wounding-induced folliculogenesis, whereas overexpression of Wnt ligand in the epidermis increases the number of regenerated hair follicles."

I wonder if this (WnT signalling) study has been conducted in the presence of DHT and receptor diminishing regimen for such.

[Forestry]

a related study

Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial.
...
These results demonstrate that a single intradermal administration of HSC improved hair growth in subjects with androgenetic alopecia and is a clinical substantiation of previous preclinical research with Wnts, follistatin, and other growth factors associated with wound healing and regeneration.

[Seuxin]

WNT agonist is very important.

TheKaneShop is selling a WNT agonist named "6BIo", as 99$ for 500mg. Nevertheless i don't know the amount to use per day. I think it's a little amount because WNT agonist at high dose can be dangerous.

It can be a good addition...

In addition, Follistatin is VERY IMPORTANT for hair, it's used in the famous Histogen ( HSC) protocol ( KGF, VEGF, and Follistatin), nevertheless AFAIK, there is different type of follistatin....Maybe it could be good to find a simple an cheap way to increase production of follistatin.

-> Increasing VEGF is simple ( With hypoxia like Stemoxydine, or with Minoxidil )
-> Increasing KGF is simple ( With Minoxidil, or buying directky KGF for cheap on the skinactive website )

So we need to find a way to increase Follistatin !

And we have to find the amount to use for 6-BIO.

[SriHanuman]

rice bran:

http://www.ncbi.nlm.nih.gov/pubmed/24389480

http://www.ncbi.nlm.nih.gov/pubmed/26632177 full article: https://www.jstage.jst.go.jp/article...b15-00387/_pdf

[TubZy]

SO....you're paying 124$ / week for TB500 ???????

Ballin lol. Yeah I just want to see if it works well or not. Not really planning to stay on it long term unless I get pretty decent results, just need some thickening, hairline is still pretty decent (NW1).

Higher dose topical OC has seemed to cut my shedding down a lot.

I do it SubQ or IM. I think you should you at least 8mg or even 10mg if you could afford it. I have clopro coming in soon so that should be a decent growth stim combo (clopro & TB500).

[Forestry]

rice bran

I've only ready the first link SriHanuman , that is a good read and shows RB-SCE a decent alternative to minoxidil.

In terms of the stack, Linoleic Acid (LA) is there (here I'm lumping together GLA and LA) with Evening Primrose*.

The new item appears to be Gamma Oryzanol (OZ).

I wish the study went out past 4 weeks. The OZ really kicked in at week 4.

*per Wikipedia, natural sources of LA:
Name % LA
...
Safflower oil 74.62%
Evening Primrose oil 73%
...
Grape seed oil 69.6%
Sunflower oil 65.7%
...
Walnut oil 51%
Sesame oil 45%
Rice bran oil 39%

[burtandernie]

One issue I always have is some things that are natural SOUND good, but do they actually work as the small studies might seem to indicate? Tons of natural products have many of these ingredients like revivogen listed below comes to mind. It never really had much success from user stories back then, and I tried it as well back when it was the latest fad. Why would it not work if it was formulated with many of these natural ingredients your mentioning? Right off the bat it has linolenic acid, beta-sis, saw palmetto among many others.

revivogen
SD Alcohol 40 (Denat. Alcohol), Purified Water (Aqua), Linolenic Acid (Gamma & Alpha), Linoleic Acid, Oleic Acid, Saw Palmetto Extract (Serenoa Serrulata), Ethyl Laurate, Beta-Sitosterol, Caffeine, Octyl (Ethylhexyl) Gallate, Dodecyl Gallate, Pyridoxal 5-Phosphate, Tocopherol (Vitamin E), Procyanidin B2 (Vitis Vinifera Extract), Azelaic Acid , Zinc Sulfate, Menthol, EDTA, Perfume (Parfum).

[SriHanuman]

I've only ready the first link SriHanuman , that is a good read and shows RB-SCE a decent alternative to minoxidil.

Too bad, the second link is "16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO2 extract (RB-SCE) in the treatment of androgenic alopecia."

[ryan82]

WNT agonist is very important.

TheKaneShop is selling a WNT agonist named "6BIo", as 99$ for 500mg. Nevertheless i don't know the amount to use per day. I think it's a little amount because WNT agonist at high dose can be dangerous.

It can be a good addition...

In addition, Follistatin is VERY IMPORTANT for hair, it's used in the famous Histogen ( HSC) protocol ( KGF, VEGF, and Follistatin), nevertheless AFAIK, there is different type of follistatin....Maybe it could be good to find a simple an cheap way to increase production of follistatin.

-> Increasing VEGF is simple ( With hypoxia like Stemoxydine, or with Minoxidil )
-> Increasing KGF is simple ( With Minoxidil, or buying directky KGF for cheap on the skinactive website )

So we need to find a way to increase Follistatin !

And we have to find the amount to use for 6-BIO.

Bio-6 is a better VPA. Why is it dangerous with high dose? Do you have experience with bio-6?

[pepmorg79]

Hi Chemical,

I am a fan of your studies, I am fighting against hairloss since 6 years at least and I have tried a lot of treatments: FIN, MINOX, RU, KETO, CB, LATANOPROST, SETIPIPRANT, and someone more that now I don't remember it.

Last mont I have started to read you and follow your instructions and my hair are better, I have a nice regrowth that I hope continue next months. My actual treatment is:

- CB 1% (70% ethano 30% propilenglicol) at morning
- OL 1mg/ml (70% ethanol 30 %distilled water) at midday
- 1,15 mg of FIN at midday
- MINOX with OL (minox 5%, OL 1mg/ml (60mg of OL in bottle of 60ml of Minox) at night.

I think the regeneration hair is for the increase of betacatenin which produced Oleuropein, but I have some questions about OLEUROPEIN in my head wich last days I am a little worried, and I am very happy if you can answer me:

1.- betacatenin can increase the risk about the proliferation cancer cells? because I have read something in internet and I am quite worried about it.

2.- betacatenin influence in the sleeping time? because last weeks I sleep worse and a little of insomnia

3.- betacatenin can increase the oxidation of body, increase the wrinkles in the front or in the eyes, produce bones calcification? because I have my skin in nice conditions and I don¡t want destroy it

4.- other question about it is if the antioxidants can reduce the quantity of betacatenin? because I read that some antioxidants like magnesium or vit.d can reduce betacatenin

5.- if are true, what are the antioxidants who affect betacatenin in major percentage? do you know about vit c or vit e effects?
Because the objective global is can regrowth hair without generate radical free or maintaining the skin in good conditions.

6.- the last question is about diet: what can I do with our diet relationed with betacatenin? If I eat a lot of verdures (brocoli, salmon, fishes, calabacin, etc..) which have antioxidant propierties are we reducing the results of OL? Or it is independent and doesn't have relationed?
Because I consume some brocoli for example, the antioxidant propierties, furthermore inhibitor aromatasa action could reduce the benefits of OL?

Sorry for a lot of questions, but I admire your studies about regrwoth hair, you have helped to start regrowth my hair and I am happy for this, now I do this questions because I am apasionate like you about find solutions of hair and I hope this solutions don't damage other things.
However, I am quite worried with the relation about betacatenin and cancer and the oxidation of body and damages skin.

I hope your answer when you can,