Updated Research and Knowledge - Cutting Edge

[BRIANBOY]

Chemical - I am currently using a 4% (2960 mg EGCG / 50% Green Tea blend, so about 1480 EGCG proper) in 74ml .......5% OL (it's a blend w/20% OL - so about 300mg of Oleuropein proper) ..... 1% Rosemary Ext ... 1% Jojoba Oil .... (.2%) Tea Tree Oil. This is in a distilled water solution. I add maybe 4 ml of 70% ethyl alcohol as well. Apply that, then wait for that to absorb and apply Minox foam, then finish with Ketoconazole 2% cream. I do this 3 times a day if possible. Scalp seems ok with this regimen so far (2 weeks). I would like to use even a higher dose of EGCG blend, but, the hair growth stimulation seems to occur just under the threshold of when the folliculitis starts. So, have to be careful. I don't want to be forced to stop treatments. Scalp feels in harmony and in a positive direction again.

[SriHanuman]

http://www.ncbi.nlm.nih.gov/pubmed/24116284

[Kokles]

http://www.ncbi.nlm.nih.gov/pubmed/24116284

Saitama? LOL! Seriously I wonder why the guy is not the poster boy for young balding men.

Anyway the numbers in the study are mighty mighty fine.

[kuba197]

Chemical,

Can you give me your e-mail or something that I could contact you.

[Seuxin]

http://www.ncbi.nlm.nih.gov/pubmed/24116284

Yeah, chemical should read this study...

[Chemical]

Im in Ireland and cannot get the product above shipped from the U.K.
I have been taking the below as a supplement http://www.comvita.com/products/oliv...-natural/H5488
Would this do mixed with Emu oil?

If you can use minox then I'd recommend you get your hands on some minox from here: http://www.kirklandminoxidiluk.co.uk/

Then you can just use this oleuropein from amazon uk and this EGCG from amazon uk too. The OL you linked doesnt have a high enough ethanol concentration and likely wont work as effectively as a minox vehicle or a custom Ethanol/PG solution. If you cant use minox then you can use this post from josh as a starting point. Alternatively you can wait for Keeper to organise a OL/EGCG trial with his contact.

Have ordered my first lot of EGCG and OL because of this thread. Fingers crossed it works!
Thanks again for your efforts; please post your pictures when you have any updates/progress! I'm not in a situation to post pictures for another 2 months but absolutely will when I can mix my new ingredients with minox.

Thank you for your kind words, it really makes me happy to know people value the research we are doing here. The biggest motivation is that I think with the combined knowledge and effort of people in this forum we can actually find something that genuinely woks to regrow hair - and keep it. I will indeed be posting more pictures as I see progress. I hope this really works for you and everyone else who's decided go ahead and try this experiment, especially given that its still just experimental research with little real world evidence.

Chemical - I am currently using a 4% (2960 mg EGCG / 50% Green Tea blend, so about 1480 EGCG proper) in 74ml .......5% OL (it's a blend w/20% OL - so about 300mg of Oleuropein proper) ..... 1% Rosemary Ext ... 1% Jojoba Oil .... (.2%) Tea Tree Oil.

Thats an awfully high amount of OL you're using and EGCG too. I would definitely lower the OL if you can but i not, then I'm interested to see how the higher dose works. I have a few questions. Does the EGCG dissolve well in just water and do you notice any crystal-like residue left after it dries up? I think I will get in contact wit hthe Oleuropein study researchers to find out what happened when they used 3mg OL.

http://www.ncbi.nlm.nih.gov/pubmed/24116284

That is an amazing find SriHanuman. According to the study, PGE2 was increased but I couldnt see where they mentioned how it that. They also mentioned minox increasing COX-1 as a mechanism for increasing PGE2, so if G. elliptica increases cox-1 then it wont be anymore useful than using other ways of increasing COX-1/2 production. However it does have strong 5ar inihibitory properties that are dose dependent. The only problem is its quite to find (I didnt look hard enough?).

Rosmarinus officinalis . Its available from amazon uk too. As Brian has shown, rosemary has AR and 5ar suppressive properties making it a potential treatment to stack with EGCG.

Herse the complete list of treatments we have available so far:

Oleuropein: ¬DKK1, ->WNT10b, ->IGF-1, ->BetaCatenin
Emu oil: ¬5ar, ¬DKK1 (via antioxidant activity)
EGCG: ¬Axin, ¬AR, ->BetaCatenin
Rosmarinus Officinalis: ¬AR, ¬5ar (Only rosemary extract not oil or rosmarinic acid)
Gamma Linoleic: ¬5ar (Evening primrose extract)
Procyanidins: ¬PKC, ->BetaCatenin (Apple polyphenols/Grape seed extract)
Forskolin?: ->PKA
Valproic Acid: ¬GSK3b, ->BetaCatenin
Miconazole/Ketoconazole: ¬17bHSD ¬3bHSD

@Kuba197

I would encourage you to ask any questions you may have on the forums so that it may help anyone else who might have the same question. If you truly must contact me in private then: chemxrs at gmail dot com (I hope I dont get in trouble for doing this)

[Seuxin]

You really have to forget about emu oil ! There is really no REAL SCIENTIST STUDY about emu oil. Emu oil is just a scam for hairloss, it don't decrease 5AR or DHT

What about Zinc/Zinc Sulphate, Vitamin B6, BetaSitosterol ? It can be a good addition.
In addition, you're attacki AR/5AR/DHT/DKK1 but you should find a way to increase grow factor...because if you want regrowth, you need grow factor (VEGF-> Increased with stemoxydine, but there is FGF ; KGF ; Follistatin).

Look at thistogen : They just play on grow factors...not on DHT and look at the regrowth ! Awesome !

Conclusion : Your idea is good, but now, you should find treatements to add which can increase grow factors ( FGF, KGF, VEGF, FOLLISTATIN, PGE2)

[BRIANBOY]

Chemical - I am using higher EGCG because I have used at least that strength before, and had no problems. Yes, it dissolves completely in distilled water. It will be a brown color, and stains anything it touches. As for the OL .5%, that's the percentage recommended by SkinActives.com for oleuropein in topical formulations. We'll see how it goes.

[BRIANBOY]

I have also added 50 mcg of KGF (from Skinactives.com) to 74ml of solution. Don't want to add anything else, as my scalp seems to be ok with the ingredients and percentages currently.

[SriHanuman]

That is an amazing find SriHanuman. According to the study, PGE2 was increased but I couldnt see where they mentioned how it that. They also mentioned minox increasing COX-1 as a mechanism for increasing PGE2, so if G. elliptica increases cox-1 then it wont be anymore useful than using other ways of increasing COX-1/2 production. However it does have strong 5ar inihibitory properties that are dose dependent. The only problem is its quite to find (I didnt look hard enough?).

I can't find it either, sadly, but will go on searching... One question about EGCG, does it stain much, as in, does it show on scalp or not?

[SriHanuman]

I found this, similiar, can get the extract on amazon:

http://www.mdpi.com/1422-0067/13/5/6407/htm

https://www.amazon.co.uk/s/ref=nb_sb_ss_c_0_8?url=search-alias%3Daps&field-keywords=ecklonia+cava&sprefix=ecklonia+cava%2Caps%2C180

[Sogeking]

At what concentrations should one use primrose oil, grape seed extract and rosemary extract?

Also it would be cool if we could find a source for Grateloupia elliptica.

[SriHanuman]

wnt agonist:

http://www.sciencedirect.com/science/article/pii/S0024320512005073

fo-ti, upregulating Shh and β-catenin expression:

http://www.sciencedirect.com/science/article/pii/S0378874111001644

[ryan82]

Very interesting this!

[ryan82]

its boost testosterone levels ? That is bad for hair?

http://www.ergo-log.com/oleuropein-boosts-testosterone-lowers-cortisol-stimulates-anabolism.html