New Graza study on follicle neogenesis through wounding.

[bboy5]

Not sure if this is something we don't already know, but it's a new study that seems to have made a significant step forward in how to create follicle neogenesis through wounding.

Regeneration of skin and hair follicles after wounding—a process known as wound-induced hair neogenesis (WIHN)—is a rare example of adult organogenesis in mammals. As such, WIHN provides a unique model system for deciphering mechanisms underlying mammalian regeneration. Here, we show that dsRNA, which is released from damaged skin, activates Toll-Like Receptor 3 (TLR3) and its downstream effectors IL-6 and STAT3 to promote hair follicle regeneration. Conversely, TLR3-deficient animals fail to initiate WIHN. TLR3 activation promotes expression of hair follicle stem cell markers and induces elements of the core hair morphogenetic program, including ectodysplasin A receptor (EDAR) and the Wnt and Shh pathways. Our results therefore show that dsRNA and TLR3 link the earliest events of mammalian skin wounding to regeneration and suggest potential therapeutic approaches for promoting hair neogenesis.

http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2815%2900307-0

[lacazette]

Damn good Bboy!!

Those researchers are identifiyng what Costarelis/follica were searching! Cotsarelis/millar talked only about activation of the Wnt pathway after wounding a few years ago,but it was not sufficient.
here the researchers seems to have found what Cotsarelis have to manipulate to induce and develop follicle after wounding!


•dsRNA released after skin injury triggers skin regeneration via TLR3
•IL-6 and Stat3 signaling, downstream mediators of TLR3, are key to regeneration
•Loss of TLR3, IL-6Ra, or Stat3 reduces hair neogenesis after wounding
•TLR3 induces core hair morphogenetic programs and hair follicle markers



" TLR3 activation promotes expression of hair follicle stem cell markers and induces elements of the core hair morphogenetic program, including ectodysplasin A receptor (EDAR) and the Wnt and Shh pathways "

If that solve a part of the puzzle, woundneogenesis cure, can come far sooner than stem cells, bioengineering,etc!!

[baldybald]

For some reasons, the news did not make me excited

[hellouser]

For some reasons, the news did not make me excited

Is it because it'll probably be tested on MICE for the next 10 years?

[joachim]

similar article here, a bit better summarized:

http://www.iflscience.com/health-and-medicine/key-pathway-hair-follicles-and-skin-regeneration-could-be-game-change-burn

i think this discovery is important and maybe indeed the last puzzle for effective wound-induced hairs. i wonder if cotsarelis is aware of that discovery.
so, what else do they need now? start lasering the skin and try that discovery on humans already! oh no, wait, it's easier to ignore the discovery and try more fancy theories on mice.

[dutchguyhanging]

i just think we need to close the whole thread even entire cutting edge section. I mean we dont care about the treatments which are 20 years away.. I am gonna drop an email to Spencer to close this section entirely. We should not sell hope to people but reality

[tiktok]

i just think we need to close the whole thread even entire cutting edge section. I mean we dont care about the treatments which are 20 years away.. I am gonna drop an email to Spencer to close this section entirely. We should not sell hope to people but reality

lol, this guy!

[dutchguyhanging]

there is no lol, I was NW1 when I was first lurking this forum, now NW5.. yet nothing has changed

[diffuseloser]

No offense but, what is it with you Dutch guys? You make Arashi look like Santa Claus. Yeah, let's just go ahead and close the whole cutting edge section. Wouldn't that be just great.

[JayM]

i just think we need to close the whole thread even entire cutting edge section. I mean we dont care about the treatments which are 20 years away.. I am gonna drop an email to Spencer to close this section entirely. We should not sell hope to people but reality

Stop speaking for other people dude. We get it. You are struggling with your hairloss. We all are, that's why we're here. But to think stifling debate and knowledge is going to help anyone then you are wrong. Just don't come to this section if you can't handle it. I suffer from hairloss but I also suffer from other things as well. Replicel have given me hope that I can avoid surgery on my knee because of their developments as well. This is a place to discuss science. The ins and outs of all new findings. If it does take 20 years then there will be YEARS of threads containing a year to year history of development.

I'm not saying that this section is perfect, half of these threads are full of people fu*king breaking down mentally and being unhinged but all the information is there and its quality stuff when you sift through the sh*t. People come here and read things and they can start to build a picture of where we are right now. Most importantly they can become educated! This whole forum keeps posting better and better things because over the years people have had the resources documented here to articulate themselves and use the resources to learn. I slam sensationalist titles including things like "cure" because that can give false hope.

Science is reality. You guestimating isn't. When people are optimistic and say "oh yeh it could be sooner because of 21st century cure act" ect then the respected quality posters will give a concise reasoning back as to why this won't happen soon/could be a possibility. Posters like Desmond are quality at this. There will always be w*nk comments in between, as you have so nicely demonstrated, but people with IQ's higher than their age can ignore this and make their own decision.

[diffuseloser]

Stop speaking for other people dude. We get it. You are struggling with your hairloss. We all are, that's why we're here. But to think stifling debate and knowledge is going to help anyone then you are wrong. Just don't come to this section if you can't handle it. I suffer from hairloss but I also suffer from other things as well. Replicel have given me hope that I can avoid surgery on my knee because of their developments as well. This is a place to discuss science. The ins and outs of all new findings. If it does take 20 years then there will be YEARS of threads containing a year to year history of development.

I'm not saying that this section is perfect, half of these threads are full of people fu*king breaking down mentally and being unhinged but all the information is there and its quality stuff when you sift through the sh*t. People come here and read things and they can start to build a picture of where we are right now. Most importantly they can become educated! This whole forum keeps posting better and better things because over the years people have had the resources documented here to articulate themselves and use the resources to learn. I slam sensationalist titles including things like "cure" because that can give false hope.

Science is reality. You guestimating isn't. When people are optimistic and say "oh yeh it could be sooner because of 21st century cure act" ect then the respected quality posters will give a concise reasoning back as to why this won't happen soon/could be a possibility. Posters like Desmond are quality at this. There will always be w*nk comments in between, as you have so nicely demonstrated, but people with IQ's higher than their age can ignore this and make their own decision.

+1 to that

[Swooping]

This is freaking awesome. Can I possibly get NW -2 with this?

Anyone know where I can buy a TLR3 peptide/small molecule?

[lacazette]

"Clinical translation of these findings is promising and has begun, with products targeted at activating TLR3, with the aim of trigger the immune system, already in development which could potentially be applied to the promotion of regeneration."

When the safely product will be ready to test, i really think Cotsarelis method could give some results. Wounding our scalp, activate TLR3 to create the hair follicles, and then overactivate the Wnt pathway !Damn I can't believe we won't have hair with that protocol, even small ones x) Fingers crossed

[JayM]

If you got a HT and then you could use this at the extraction site. If its that good then you could regenerate your whole donor area. If I was running a HT clinic I would certainly look into that.

[Renee]

I believe in that wounding can grow hair. My father tells me a story from the 1990's of a family friend who was nw7 and 94 years of age. For some reason because of old age developed excessive wounds on his scalp and all of a sudden he started to grow brand new black hairs. Doctors were amazed and couldn't believe it. They invited him to UCLA for tests and unfortunately brief time period after that he passed.