Tsuji labs news????

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  • lacazette
    Senior Member
    • May 2015
    • 394

    #16
    (Tsuji Lab) created a bioengineered hair follicle germ using embryonic skin-derived epithelium and mesenchymal donor cells.

    The two are now possible with iPSC

    xu team : "The researchers then converted iPSCs into a large number of epithelial stem cells" 2014

    And for mesenchymal also :

    "Here we report generation of induced pluripotent stem cells (iPSC)-derived MSCs.
    Starting from iPSCs with almost unlimited expandability, the protocol can be readily scaled up to provide huge amounts of MSCs with uniform biological properties for multicenter evaluation, large animal experiments, and potential clinical trial"
    2014

    Come on tsuji test it on human!!

    Comment

    • Renee
      Senior Member
      • Jul 2015
      • 196

      #17
      On the university website dr Tsuji says hair will be available in 5-10 years and teeth regeneration will be available in 2-3 decades.

      Comment

      • Renee
        Senior Member
        • Jul 2015
        • 196

        #18
        Lacazette, so he will grow the follicles in a dish and transplant it one by one? Or it will be an injection?

        Comment

        • lacazette
          Senior Member
          • May 2015
          • 394

          #19
          Hey Renee, seems taht the text with this quote is from 2013 (bottom of the page)

          (If we don't take in consideration that he could have unespected issues, or at contrary the progress of technologies and knowledge those last two years), we could probably talk more about 3-8 years for the public. Let's hope exponential progress will diminish the timeline if they're not already in human trial

          @Renee, on their mouse study they grew 'HF germ' and they injected them. But I also see they use the word 'transplanted them'
          So maybe in this organ germ method, 'accurate injection of a hair germ' and 'transplantation of a hair germ' means the same. Or maybe there really are two ways to implant them i don't know.

          Quote from Desmond in a 2013 topic :

          According to their last study, they injected 24 "hair germs" into a 1cm2 area to yield approximately 120 hairs/cm2.

          Comment

          • Swooping
            Senior Member
            • May 2014
            • 794

            #20


            I have recently spoken to Dr. Takashi Tsuji. They are still encountering problems, most notably the critical issue of expansion of the epithelial bulge stem cells. When they overcome the problems they will initiate a pre-clinical study to test for safety followed by human clinical trials. He is confident that the method will succeed in humans too.

            It's a shame I can't speak Japanese to get to know more from this very bright yet humble person. They are probably the closest too a full cure imo. We'll have to wait, definitely worth following though. Might be our hero one day .

            Real research, real possibilities.

            Comment

            • ShookOnes
              Senior Member
              • Jun 2014
              • 209

              #21
              Originally posted by hellouser
              What an astonishing negative assumption and illogic.

              Ok bro

              Comment

              • Xoxo
                Junior Member
                • Jun 2014
                • 17

                #22
                Originally posted by Swooping
                They are still encountering problems, most notably the critical issue of expansion of the epithelial bulge stem cells. When they overcome the problems they will initiate a pre-clinical study to test for safety followed by human clinical trials. He is confident that the method will succeed in humans too.
                Seems light years away.

                Comment

                • Swooping
                  Senior Member
                  • May 2014
                  • 794

                  #23
                  Originally posted by Xoxo
                  Seems light years away.
                  Jup, very promising technology but it will still take some time. Let's hope they fix those problems asap so they can initiate pre-clinical trials.

                  Comment

                  • joachim
                    Senior Member
                    • May 2014
                    • 559

                    #24
                    Originally posted by Swooping
                    Jup, very promising technology but it will still take some time. Let's hope they fix those problems asap so they can initiate pre-clinical trials.
                    look at this swooping:
                    Scientists have successfully converted human skin cells into fully-functional pancreatic cells. The new cells produced insulin in response to changes in glucose levels, and, when transplanted into mice, the cells protected the animals from developing diabetes in a mouse model of the disease.


                    another advancement in cell culturing through transforming them stemcell like states (an intermediate state between pluripotent and fully developed adult cells).

                    with such techniques they are able to multiply millions and billions of those nice cells fully functioning.
                    we here those news almost weekly now, and yet nobody has achieved the same for DP cells or other hair-related cells.
                    i think this is not because it's more difficult but because only a handful of researchers are caring about hair-related cells.

                    if we could get some of those great scientists to work on hairloss, it could be solved very quickly.
                    i wonder how far dr. Xu is with his research. are you still in contact with him? does he still take hairloss research serious and is actively working on it?

                    Comment

                    • Swooping
                      Senior Member
                      • May 2014
                      • 794

                      #25
                      @joachim.

                      Jup, very exciting stuff. I think when Tsuji actually manages to fix the problems that will be a very huge step forward.. I never had contact with Dr. Xu though I think that was someone else. So I dunno about that.

                      Comment

                      • Sogeking
                        Senior Member
                        • Feb 2011
                        • 494

                        #26
                        Originally posted by Swooping
                        @joachim.

                        Jup, very exciting stuff. I think when Tsuji actually manages to fix the problems that will be a very huge step forward.. I never had contact with Dr. Xu though I think that was someone else. So I dunno about that.
                        I'm with you on rooting for Dr. Tsuji. Although I'm aware that this is probably 10+ years away..

                        Comment

                        • FooFighter
                          Member
                          • Feb 2015
                          • 90

                          #27
                          Originally posted by joachim
                          look at this swooping:
                          Scientists have successfully converted human skin cells into fully-functional pancreatic cells. The new cells produced insulin in response to changes in glucose levels, and, when transplanted into mice, the cells protected the animals from developing diabetes in a mouse model of the disease.


                          another advancement in cell culturing through transforming them stemcell like states (an intermediate state between pluripotent and fully developed adult cells).

                          with such techniques they are able to multiply millions and billions of those nice cells fully functioning.
                          we here those news almost weekly now, and yet nobody has achieved the same for DP cells or other hair-related cells.
                          i think this is not because it's more difficult but because only a handful of researchers are caring about hair-related cells.

                          if we could get some of those great scientists to work on hairloss, it could be solved very quickly.
                          i wonder how far dr. Xu is with his research. are you still in contact with him? does he still take hairloss research serious and is actively working on it?
                          Do you really believe in everthing that is published on webs? I am convinced that 95% of this articles are false.

                          Comment

                          • Swooping
                            Senior Member
                            • May 2014
                            • 794

                            #28
                            Originally posted by Sogeking
                            I'm with you on rooting for Dr. Tsuji. Although I'm aware that this is probably 10+ years away..
                            Yes. All we can do is just hope they proceed in fixing their problems as soon as possible Sogeking .

                            Comment

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